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Research Article

Suppression of Virus Specific Immune Responses by IL-10 in Acute Dengue Infection

  • Gathsaurie Neelika Malavige mail,

    gathsaurie.malavige@ndm.ox.ac.uk

    Affiliations: Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

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  • Chandima Jeewandara,

    Affiliation: Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka

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  • K. M. Luckmaal Alles,

    Affiliation: Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka

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  • Maryam Salimi,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

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  • Laksiri Gomes,

    Affiliation: Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka

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  • Achala Kamaladasa,

    Affiliation: Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka

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  • S. D. Jayaratne,

    Affiliation: Department of Medicine, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka

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  • Graham Stuart Ogg

    Affiliations: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom, Department of Dermatology, Churchill Hospital, Oxford, United Kingdom

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  • Published: September 05, 2013
  • DOI: 10.1371/journal.pntd.0002409

About the Authors

Gathsaurie Neelika Malavige, Chandima Jeewandara, K. M. Luckmaal Alles, Laksiri Gomes, Achala Kamaladasa
Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka
Gathsaurie Neelika Malavige, Maryam Salimi, Graham Stuart Ogg
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
S. D. Jayaratne
Department of Medicine, Faculty of Medical Sciences, University of Sri Jayawardanapura, Gangodawila, Nugegoda, Sri Lanka
Graham Stuart Ogg
Department of Dermatology, Churchill Hospital, Oxford, United Kingdom

Corresponding Author

Email: gathsaurie.malavige@ndm.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GNM GSO. Performed the experiments: CJ KMLA LG AK. Analyzed the data: GNM MS. Contributed reagents/materials/analysis tools: GSO GNM SDJ. Wrote the paper: GNM GSO. Helped in recruitment of patients and defining clinical disease severity: SDJ..