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Research Article

A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease

  • Suganya Selvarajah,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Nicole R. Sexton,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

    Current address: Vanderbilt University, Nashville, Tennessee, United States of America

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  • Kristen M. Kahle,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Rachel H. Fong,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Kimberly-Anne Mattia,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Joy Gardner,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Kai Lu,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Nathan M. Liss,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Beatriz Salvador,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • David F. Tucker,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Trevor Barnes,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Manu Mabila,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Xiangdong Zhou,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Giada Rossini,

    Affiliation: DIMES, Microbiology, University of Bologna, Bologna, Italy

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  • Joseph B. Rucker,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • David Avram Sanders,

    Affiliation: Purdue University, West Lafayette, Indiana, United States of America

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  • Andreas Suhrbier,

    Affiliation: Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Vittorio Sambri,

    Affiliation: DIMES, Microbiology, University of Bologna, Bologna, Italy

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  • Alain Michault,

    Affiliation: Centre Hospitalier Universitaire, Groupe Hospitalier Sud-Réunion, La Reunion, France

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  • Marcus O. Muench,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Benjamin J. Doranz,

    Affiliation: Integral Molecular, Philadelphia, Pennsylvania, United States of America

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  • Graham Simmons mail

    gsimmons@bloodsystems.org

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: September 12, 2013
  • DOI: 10.1371/journal.pntd.0002423

About the Authors

Suganya Selvarajah, Nicole R. Sexton, Kai Lu, Nathan M. Liss, Beatriz Salvador, Marcus O. Muench, Graham Simmons
Blood Systems Research Institute, San Francisco, California, United States of America
Suganya Selvarajah, Kai Lu, Nathan M. Liss, Beatriz Salvador, Marcus O. Muench, Graham Simmons
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America
Kristen M. Kahle, Rachel H. Fong, Kimberly-Anne Mattia, David F. Tucker, Trevor Barnes, Manu Mabila, Xiangdong Zhou, Joseph B. Rucker, Benjamin J. Doranz
Integral Molecular, Philadelphia, Pennsylvania, United States of America
Joy Gardner, Andreas Suhrbier
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Giada Rossini, Vittorio Sambri
DIMES, Microbiology, University of Bologna, Bologna, Italy
David Avram Sanders
Purdue University, West Lafayette, Indiana, United States of America
Alain Michault
Centre Hospitalier Universitaire, Groupe Hospitalier Sud-Réunion, La Reunion, France

Corresponding Author

Email: gsimmons@bloodsystems.org

Competing Interests

I have read the journal's policy and have the following conflicts: JBR and BJD are shareholders in Integral Molecular. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KMK RHF JBR AS MOM BJD GS. Performed the experiments: SS NRS KMK RHF KAM JG KL NML BS MM XZ MOM GS. Analyzed the data: SS KMK RHF DFT TB XZ JBR AS MOM BJD GS. Contributed reagents/materials/analysis tools: KAM DFT TB MM GR DAS VS AM. Wrote the paper: SS KMK RHF BJD GS.