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Research Article

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

  • Julien Lancelot,

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Stéphanie Caby,

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Florence Dubois-Abdesselem,

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Mathieu Vanderstraete,

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Jacques Trolet,

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Guilherme Oliveira,

    Affiliation: Genomics and Computational Biology Group, Center for Excellence in Bioinformatics, National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil

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  • Franz Bracher,

    Affiliation: Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, München, Germany

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  • Manfred Jung,

    Affiliation: Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany

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  • Raymond J. Pierce mail

    raymond.pierce@pasteur-lille.fr

    Affiliation: Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France

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  • Published: September 12, 2013
  • DOI: 10.1371/journal.pntd.0002428

About the Authors

Julien Lancelot, Stéphanie Caby, Florence Dubois-Abdesselem, Mathieu Vanderstraete, Jacques Trolet, Raymond J. Pierce
Center for Infection and Immunity of Lille (CIIL), INSERM U1019 – CNRS UMR 8204, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France
Guilherme Oliveira
Genomics and Computational Biology Group, Center for Excellence in Bioinformatics, National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Franz Bracher
Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, München, Germany
Manfred Jung
Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany

Corresponding Author

Email: raymond.pierce@pasteur-lille.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RJP GO MJ FB. Performed the experiments: JL SC FD JT MV. Analyzed the data: JL RJP MJ GO. Contributed reagents/materials/analysis tools: FB MJ. Wrote the paper: JL RJP MJ FB GO.