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Research Article

Lipidated Dengue-2 Envelope Protein Domain III Independently Stimulates Long-Lasting Neutralizing Antibodies and Reduces the Risk of Antibody-Dependent Enhancement

  • Chen-Yi Chiang equal contributor,

    equal contributor Contributed equally to this work with: Chen-Yi Chiang, Chien-Hsiung Pan

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Chien-Hsiung Pan equal contributor,

    equal contributor Contributed equally to this work with: Chen-Yi Chiang, Chien-Hsiung Pan

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Chun-Hsiang Hsieh,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Jy-Ping Tsai,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Mei-Yu Chen,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Hsueh-Hung Liu,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Shih-Jen Liu,

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Pele Chong,

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Chih-Hsiang Leng mail,

    leoleng@nhri.org.tw (CHL); chenhw@nhri.org.tw (HWC)

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Hsin-Wei Chen mail

    leoleng@nhri.org.tw (CHL); chenhw@nhri.org.tw (HWC)

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Published: September 19, 2013
  • DOI: 10.1371/journal.pntd.0002432

About the Authors

Chen-Yi Chiang, Chien-Hsiung Pan, Chun-Hsiang Hsieh, Jy-Ping Tsai, Mei-Yu Chen, Hsueh-Hung Liu, Shih-Jen Liu, Pele Chong, Chih-Hsiang Leng, Hsin-Wei Chen
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China
Chien-Hsiung Pan, Shih-Jen Liu, Pele Chong, Chih-Hsiang Leng, Hsin-Wei Chen
Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

Corresponding Authors

Competing Interests

I have read the journal's policy and have the following conflicts: HWC, CHL, SJL, and PC are named on patents relating to the lipidated vaccine against dengue virus infection. This does not alter the authors' adherence to all the PLoS Neglected Tropical Diseases policies on sharing data and materials. All other authors have no conflict of interest.

Author Contributions

Conceived and designed the experiments: CYC CHP SJL PC CHL HWC. Performed the experiments: CYC CHH JPT MYC HHL. Analyzed the data: CYC CHP CHL HWC. Contributed reagents/materials/analysis tools: CYC CHH HHL CHL HWC . Wrote the paper: CHP CHL HWC.