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Research Article

Analysis of Cross-Reactive Antibodies Recognizing the Fusion Loop of Envelope Protein and Correlation with Neutralizing Antibody Titers in Nicaraguan Dengue Cases

  • Chih-Yun Lai equal contributor,

    equal contributor Contributed equally to this work with: Chih-Yun Lai, Katherine L. Williams

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

    X
  • Katherine L. Williams equal contributor,

    equal contributor Contributed equally to this work with: Chih-Yun Lai, Katherine L. Williams

    Affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America

    X
  • Yi-Chieh Wu,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

    X
  • Sarah Knight,

    Affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America

    X
  • Angel Balmaseda,

    Affiliation: National Virology Laboratory, National Center for Diagnosis and Reference, Ministry of Health, Managua, Nicaragua

    X
  • Eva Harris mail,

    eharris@berkeley.edu (EH); wangwk@hawaii.edu (WKW)

    Affiliation: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America

    X
  • Wei-Kung Wang mail

    eharris@berkeley.edu (EH); wangwk@hawaii.edu (WKW)

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

    X
  • Published: September 19, 2013
  • DOI: 10.1371/journal.pntd.0002451

About the Authors

Chih-Yun Lai, Yi-Chieh Wu, Wei-Kung Wang
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Katherine L. Williams, Sarah Knight, Eva Harris
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, United States of America
Angel Balmaseda
National Virology Laboratory, National Center for Diagnosis and Reference, Ministry of Health, Managua, Nicaragua

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CYL KLW EH WKW. Performed the experiments: CYL KLW YCW SK. Analyzed the data: CYL KLW YCW SK EH WKW. Contributed reagents/materials/analysis tools: CYL KLW AB EH WKW. Wrote the paper: CYL KLW EH WKW.