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Research Article

Cytokine Response Signatures in Disease Progression and Development of Severe Clinical Outcomes for Leptospirosis

  • Eliana A. G. Reis,

    Affiliation: Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil

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  • José E. Hagan,

    Affiliations: Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America

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  • Guilherme S. Ribeiro,

    Affiliations: Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil, Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil

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  • Andrea Teixeira-Carvalho,

    Affiliation: René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil

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  • Olindo A. Martins-Filho,

    Affiliation: René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil

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  • Ruth R. Montgomery,

    Affiliation: Yale Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut, United States of America

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  • Albert C. Shaw,

    Affiliation: Yale Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut, United States of America

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  • Albert I. Ko,

    Affiliations: Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America

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  • Mitermayer G. Reis mail

    miter@bahia.fiocruz.br

    Affiliations: Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America

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  • Published: September 19, 2013
  • DOI: 10.1371/journal.pntd.0002457

About the Authors

Eliana A. G. Reis, José E. Hagan, Guilherme S. Ribeiro, Albert I. Ko, Mitermayer G. Reis
Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil
José E. Hagan, Albert I. Ko, Mitermayer G. Reis
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
Guilherme S. Ribeiro
Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil
Andrea Teixeira-Carvalho, Olindo A. Martins-Filho
René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil
Ruth R. Montgomery, Albert C. Shaw
Yale Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut, United States of America

Corresponding Author

Email: miter@bahia.fiocruz.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EAGR JEH GSR AIK MGR. Performed the experiments: ATC OAMF EAGR. Analyzed the data: JEH GSR EAGR AIK MGR. Contributed reagents/materials/analysis tools: EAGR JEH GSR ATC OAMF AIK MGR. Wrote the paper: EAGR JEH GSR AIK MGR. Contributed to the analysis plan and interpretation of findings, and reviewed the manuscript: RRM ACS.