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Research Article

Whole Genome Sequencing of Field Isolates Reveals a Common Duplication of the Duffy Binding Protein Gene in Malagasy Plasmodium vivax Strains

  • Didier Menard mail,

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OMP); serred@ccf.org (DS); paz@case.edu (PAZ)

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

    ‡ These authors are first co-authors.

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  • Ernest R. Chan ,

    Affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America

    ‡ These authors are first co-authors.

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  • Christophe Benedet,

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Arsène Ratsimbasoa,

    Affiliation: Direction de la lutte contre les maladies infectieuses, Ministère de la santé, du planning familial et de la protection sociale du Madagascar, Antananarivo, Madagascar

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  • Saorin Kim,

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Pheaktra Chim,

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Catherine Do,

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Benoit Witkowski,

    Affiliation: Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

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  • Remy Durand,

    Affiliation: Laboratoire de Parasitologie-Mycologie, Hôpital Avicenne, AP-HP, Bobigny, France

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  • Marc Thellier,

    Affiliation: National Center for Malaria Research, AP-HP, CHU Pitie Salpêtrière, Paris, France

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  • Carlo Severini,

    Affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità (ISS), Rome, Italy

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  • Eric Legrand,

    Affiliation: Laboratoire de parasitologie, National Reference Centre of Malaria Resistance in French Guiana and West Indies, Institut Pasteur de la Guyane, Cayenne, French Guiana

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  • Lise Musset,

    Affiliation: Laboratoire de parasitologie, National Reference Centre of Malaria Resistance in French Guiana and West Indies, Institut Pasteur de la Guyane, Cayenne, French Guiana

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  • Bakri Y. M. Nour,

    Affiliation: Blue Nile National Institute for Communicable Diseases, University of Gezira, Wad Medani, Sudan

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  • Odile Mercereau-Puijalon mail,

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OMP); serred@ccf.org (DS); paz@case.edu (PAZ)

    Affiliation: Unité d'lmmunologie Moléculaire des Parasites, Institut Pasteur, Paris, France

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  • David Serre mail,

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OMP); serred@ccf.org (DS); paz@case.edu (PAZ)

    Affiliation: Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America

    These authors co-supervised the study.

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  • Peter A. Zimmerman mail

    dmenard@pasteur-kh.org (DM); omp@pasteur.fr (OMP); serred@ccf.org (DS); paz@case.edu (PAZ)

    Affiliation: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

    These authors co-supervised the study.

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  • Published: November 21, 2013
  • DOI: 10.1371/journal.pntd.0002489

About the Authors

Didier Menard, Christophe Benedet, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski
Unité d'Epidémiologie Moléculaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
Ernest R. Chan, David Serre
Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America
Arsène Ratsimbasoa
Direction de la lutte contre les maladies infectieuses, Ministère de la santé, du planning familial et de la protection sociale du Madagascar, Antananarivo, Madagascar
Remy Durand
Laboratoire de Parasitologie-Mycologie, Hôpital Avicenne, AP-HP, Bobigny, France
Marc Thellier
National Center for Malaria Research, AP-HP, CHU Pitie Salpêtrière, Paris, France
Carlo Severini
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità (ISS), Rome, Italy
Eric Legrand, Lise Musset
Laboratoire de parasitologie, National Reference Centre of Malaria Resistance in French Guiana and West Indies, Institut Pasteur de la Guyane, Cayenne, French Guiana
Bakri Y. M. Nour
Blue Nile National Institute for Communicable Diseases, University of Gezira, Wad Medani, Sudan
Odile Mercereau-Puijalon
Unité d'lmmunologie Moléculaire des Parasites, Institut Pasteur, Paris, France
Peter A. Zimmerman
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DM ERC OMP DS PAZ. Performed the experiments: ERC CB SK PC CD BW. Analyzed the data: DM ERC CB OMP DS PAZ. Contributed reagents/materials/analysis tools: DM AR RD MT CS EL LM BYMN. Wrote the paper: DM ERC OMP DS PAZ.