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Research Article

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

  • Juan Carlos Pizarro mail,

    juan.pizarro@utoronto.ca

    Affiliations: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America

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  • Tanya Hills,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Guillermo Senisterra,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Amy K. Wernimont,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Claire Mackenzie,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Neil R. Norcross,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Michael A. J. Ferguson,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Paul G. Wyatt,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Ian H. Gilbert,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Raymond Hui

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Published: October 17, 2013
  • DOI: 10.1371/journal.pntd.0002492

About the Authors

Juan Carlos Pizarro, Tanya Hills, Guillermo Senisterra, Amy K. Wernimont, Raymond Hui
The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada
Juan Carlos Pizarro
Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America
Claire Mackenzie, Neil R. Norcross, Michael A. J. Ferguson, Paul G. Wyatt, Ian H. Gilbert
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

Corresponding Author

Email: juan.pizarro@utoronto.ca

Competing Interests

Funding from commercial sources, Eli Lilly Canada, GlaxoSmithKline, Pfizer, AbbVie, Takeda, Janssen, Boehringer Ingelheim, does not alter the authors' adherence to all PLOS NTDs policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JCP TH IHG RH. Performed the experiments: JCP TH GS AKW CM NRN. Analyzed the data: JCP GS IHG RH. Contributed reagents/materials/analysis tools: GS MAJF PGW. Wrote the paper: JCP TH GS AKW IHG RH.