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Research Article

Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children

  • Danielle I. Stanisic equal contributor mail,

    equal contributor Contributed equally to this work with: Danielle I. Stanisic, Sarah Javati

    d.stanisic@griffith.edu.au (DIS); ivomueller@fastmail.fm (IM)

    Affiliations: Walter and Eliza Hall Institute, Parkville, Australia, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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  • Sarah Javati equal contributor,

    equal contributor Contributed equally to this work with: Danielle I. Stanisic, Sarah Javati

    Affiliation: Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

    X
  • Benson Kiniboro,

    Affiliation: Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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  • Enmoore Lin,

    Affiliation: Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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  • Jianlin Jiang,

    Affiliation: Emory Vaccine Center, Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, United States of America

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  • Balwan Singh,

    Affiliation: Emory Vaccine Center, Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, United States of America

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  • Esmeralda V. S. Meyer,

    Affiliation: Emory Vaccine Center, Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, United States of America

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  • Peter Siba,

    Affiliation: Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

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  • Cristian Koepfli,

    Affiliations: Walter and Eliza Hall Institute, Parkville, Australia, Swiss Tropical Institute and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Ingrid Felger,

    Affiliations: Swiss Tropical Institute and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Mary R. Galinski,

    Affiliations: Emory Vaccine Center, Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, United States of America, Department of Medicine, Division of Infectious Disease, Emory University, Atlanta, Georgia, United States of America

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  • Ivo Mueller mail

    d.stanisic@griffith.edu.au (DIS); ivomueller@fastmail.fm (IM)

    Affiliations: Walter and Eliza Hall Institute, Parkville, Australia, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain

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  • Published: November 14, 2013
  • DOI: 10.1371/journal.pntd.0002498

About the Authors

Danielle I. Stanisic, Cristian Koepfli, Ivo Mueller
Walter and Eliza Hall Institute, Parkville, Australia
Danielle I. Stanisic, Sarah Javati, Benson Kiniboro, Enmoore Lin, Peter Siba, Ivo Mueller
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
Jianlin Jiang, Balwan Singh, Esmeralda V. S. Meyer, Mary R. Galinski
Emory Vaccine Center, Yerkes National Primate Research Centre, Emory University, Atlanta, Georgia, United States of America
Cristian Koepfli, Ingrid Felger
Swiss Tropical Institute and Public Health Institute, Basel, Switzerland
Cristian Koepfli, Ingrid Felger
University of Basel, Basel, Switzerland
Mary R. Galinski
Department of Medicine, Division of Infectious Disease, Emory University, Atlanta, Georgia, United States of America
Ivo Mueller
Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DIS MRG IM. Performed the experiments: DIS SJ BK EL CK. Analyzed the data: DIS IM. Contributed reagents/materials/analysis tools: JJ BS EVSM PS IF. Wrote the paper: DIS SJ MRG IM.