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Research Article

Polyfunctional T Cell Responses in Children in Early Stages of Chronic Trypanosoma cruzi Infection Contrast with Monofunctional Responses of Long-term Infected Adults

  • María C. Albareda,

    Affiliations: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina, Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Ana M. De Rissio,

    Affiliation: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina

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  • Gonzalo Tomas,

    Affiliation: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina

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  • Alicia Serjan,

    Affiliation: Hospital Fernandez, Buenos Aires, Argentina

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  • María G. Alvarez,

    Affiliation: Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Rodolfo Viotti,

    Affiliation: Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Laura E. Fichera,

    Affiliation: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina

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  • Mónica I. Esteva,

    Affiliation: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina

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  • Daniel Potente,

    Affiliation: Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Alejandro Armenti,

    Affiliation: Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Rick L. Tarleton,

    Affiliation: Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America

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  • Susana A. Laucella mail

    slaucella@yahoo.com

    Affiliations: Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina, Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

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  • Published: December 12, 2013
  • DOI: 10.1371/journal.pntd.0002575

About the Authors

María C. Albareda, Ana M. De Rissio, Gonzalo Tomas, Laura E. Fichera, Mónica I. Esteva, Susana A. Laucella
Instituto Nacional de Parasitología Dr. M. Fatala Chaben, Buenos Aires, Argentina
María C. Albareda, María G. Alvarez, Rodolfo Viotti, Daniel Potente, Alejandro Armenti, Susana A. Laucella
Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina
Alicia Serjan
Hospital Fernandez, Buenos Aires, Argentina
Rick L. Tarleton
Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America

Corresponding Author

Email: slaucella@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAL MCA RLT. Performed the experiments: MCA SAL MGA AMDR AA DP GT AS MIE LEF. Analyzed the data: MCA SAL MGA RV. Contributed reagents/materials/analysis tools: SAL RLT. Wrote the paper: SAL RLT MCA.