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Research Article

Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance

  • Maia A. Rabaa,

    Affiliations: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Cameron P. Simmons,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Annette Fox,

    Affiliations: Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hanoi, Vietnam

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  • Mai Quynh Le,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Thuy Thi Thu Nguyen,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Hai Yen Le,

    Affiliation: Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Robert V. Gibbons,

    Affiliation: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

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  • Xuyen Thanh Nguyen,

    Affiliation: Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Edward C. Holmes,

    Affiliations: Marie Bashir Institute for Emerging Diseases and Biosecurity, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • John G. Aaskov mail

    j.aaskov@qut.edu.au

    Affiliations: Queensland University of Technology, Brisbane, Australia, Australian Army Malaria Institute, Brisbane, Australia

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  • Published: December 05, 2013
  • DOI: 10.1371/journal.pntd.0002581

About the Authors

Maia A. Rabaa
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Maia A. Rabaa, Cameron P. Simmons
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Cameron P. Simmons, Annette Fox
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
Annette Fox
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
Mai Quynh Le, Thuy Thi Thu Nguyen
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Hai Yen Le, Xuyen Thanh Nguyen
Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Robert V. Gibbons
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Edward C. Holmes
Marie Bashir Institute for Emerging Diseases and Biosecurity, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
Edward C. Holmes
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
John G. Aaskov
Queensland University of Technology, Brisbane, Australia
John G. Aaskov
Australian Army Malaria Institute, Brisbane, Australia

Corresponding Author

Email: j.aaskov@qut.edu.au

Competing Interests

There were no conflicts of interest. The views expressed in this article are those of the authors and do not represent the official policy or position of the Australian Department of Defence, the U.S. Department of the Army, U.S. Department of Defense, or the U.S. Government.

Author Contributions

Conceived and designed the experiments: MAR CPS AF ECH JGA. Performed the experiments: CPS AF LMQ NTTT LHY NXT. Analyzed the data: MAR. Contributed reagents/materials/analysis tools: CPS AF LMQ NTTT LHY RVG NXT. Wrote the paper: MAR CPS AF ECH JGA.