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Research Article

Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells

  • Xueqing Chen equal contributor,

    equal contributor Contributed equally to this work with: Xueqing Chen, Shan Li

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Shan Li equal contributor,

    equal contributor Contributed equally to this work with: Xueqing Chen, Shan Li

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Lei He,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Xiaoyun Wang,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Pei Liang,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Wenjun Chen,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Meng Bian,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Mengyu Ren,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Jinsi Lin,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Chi Liang,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Jin Xu,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Zhongdao Wu,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Xuerong Li,

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Yan Huang mail,

    huang66@mail.sysu.edu.cn (YH); yuxb@mail.sysu.edu.cn (XY)

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Xinbing Yu mail

    huang66@mail.sysu.edu.cn (YH); yuxb@mail.sysu.edu.cn (XY)

    Affiliations: Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

    X
  • Published: December 19, 2013
  • DOI: 10.1371/journal.pntd.0002606

About the Authors

Xueqing Chen, Shan Li, Lei He, Xiaoyun Wang, Pei Liang, Wenjun Chen, Meng Bian, Mengyu Ren, Jinsi Lin, Chi Liang, Jin Xu, Zhongdao Wu, Xuerong Li, Yan Huang, Xinbing Yu
Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China
Xueqing Chen, Shan Li, Lei He, Xiaoyun Wang, Pei Liang, Wenjun Chen, Meng Bian, Mengyu Ren, Jinsi Lin, Chi Liang, Jin Xu, Zhongdao Wu, Xuerong Li, Yan Huang, Xinbing Yu
Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YH XY. Performed the experiments: XC SL. Analyzed the data: XC YH CL ZW JX MR. Contributed reagents/materials/analysis tools: XW PL WC LH SL XL JL MB. Wrote the paper: XC YH.