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Research Article

Favipiravir (T-705) Inhibits Junín Virus Infection and Reduces Mortality in a Guinea Pig Model of Argentine Hemorrhagic Fever

  • Brian B. Gowen mail,

    brian.gowen@usu.edu

    Affiliations: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America, School of Veterinary Medicine, Utah State University, Logan, Utah, United States of America

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  • Terry L. Juelich,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Eric J. Sefing,

    Affiliations: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America

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  • Trevor Brasel,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Jennifer K. Smith,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Lihong Zhang,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Bersabeh Tigabu,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Terence E. Hill,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Tatyana Yun,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Colette Pietzsch,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Yousuke Furuta,

    Affiliation: Research Laboratories, Toyama Chemical Company, Ltd., Toyama, Japan

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  • Alexander N. Freiberg

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: December 26, 2013
  • DOI: 10.1371/journal.pntd.0002614

About the Authors

Brian B. Gowen, Eric J. Sefing
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
Brian B. Gowen, Eric J. Sefing
Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America
Brian B. Gowen
School of Veterinary Medicine, Utah State University, Logan, Utah, United States of America
Terry L. Juelich, Jennifer K. Smith, Lihong Zhang, Terence E. Hill, Tatyana Yun, Colette Pietzsch, Alexander N. Freiberg
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America
Trevor Brasel, Bersabeh Tigabu
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
Yousuke Furuta
Research Laboratories, Toyama Chemical Company, Ltd., Toyama, Japan
Alexander N. Freiberg
Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, Texas, United States of America
Alexander N. Freiberg
Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

Corresponding Author

Email: brian.gowen@usu.edu

Competing Interests

I have read the journal's policy and have the following conflicts: YF is an employee of the Toyama Chemical Co., Ltd., the manufacturer of favipiravir. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BBG YF ANF. Performed the experiments: TLJ EJS TB JKS LZ BT TEH TY CP ANF. Analyzed the data: BBG YF ANF. Contributed reagents/materials/analysis tools: YF. Wrote the paper: BBG.