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Research Article

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

  • Gregory J. Crowther,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Michael L. Booker,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

    X
  • Min He,

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

    X
  • Ting Li,

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

    X
  • Sylvine Raverdy,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

    X
  • Jacopo F. Novelli,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

    X
  • Panqing He,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Natalie R. G. Dale,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Amy M. Fife,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

    X
  • Robert H. Barker Jr,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

    X
  • Martin L. Kramer,

    Affiliation: Genzyme Corporation, Waltham, Massachusetts, United States of America

    X
  • Wesley C. Van Voorhis,

    Affiliation: Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America

    X
  • Clotilde K. S. Carlow,

    Affiliation: Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

    X
  • Ming-Wei Wang mail

    wangmw@mail.shcnc.ac.cn

    Affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

    X
  • Published: January 09, 2014
  • DOI: 10.1371/journal.pntd.0002628

About the Authors

Gregory J. Crowther, Panqing He, Natalie R. G. Dale, Wesley C. Van Voorhis
Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America
Michael L. Booker, Amy M. Fife, Robert H. Barker Jr, Martin L. Kramer
Genzyme Corporation, Waltham, Massachusetts, United States of America
Min He, Ting Li, Ming-Wei Wang
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Sylvine Raverdy, Jacopo F. Novelli, Clotilde K. S. Carlow
Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America

Corresponding Author

Email: wangmw@mail.shcnc.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJC MLB PH MLK WCVV CKSC MWW. Performed the experiments: GJC MH TL SR JFN PH NRGD AMF . Analyzed the data: GJC MLB MH TL SR JN PH NRGD AMF RHB MLK WCVV CKSC MWW. Contributed reagents/materials/analysis tools: MLB MH TL AMF RHB MLK WCVV MWW. Wrote the paper: GJC MLB RHB WCVV CKSC MWW.