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Research Article

A High Resolution Case Study of a Patient with Recurrent Plasmodium vivax Infections Shows That Relapses Were Caused by Meiotic Siblings

  • Andrew Taylor Bright,

    Affiliations: Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, California, United States of America, Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, United States of America

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  • Micah J. Manary,

    Affiliations: Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, California, United States of America, Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, United States of America

    X
  • Ryan Tewhey,

    Affiliations: Scripps Genomic Medicine, The Scripps Translational Science Institute, La Jolla, California, United States of America, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • Eliana M. Arango,

    Affiliation: Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia

    X
  • Tina Wang,

    Affiliation: Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, California, United States of America

    X
  • Nicholas J. Schork,

    Affiliations: Scripps Genomic Medicine, The Scripps Translational Science Institute, La Jolla, California, United States of America, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • Stephanie K. Yanow mail,

    Stephanie.Yanow@albertahealthservices.ca (SKY, for clinical questions); ewinzeler@ucsd.edu (EAW, for sequencing questions)

    Affiliations: School of Public Health, University of Alberta, Edmonton, Alberta, Canada, Provincial Laboratory for Public Health, Edmonton, Alberta, Canada

    X
  • Elizabeth A. Winzeler mail

    Stephanie.Yanow@albertahealthservices.ca (SKY, for clinical questions); ewinzeler@ucsd.edu (EAW, for sequencing questions)

    Affiliation: Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, United States of America

    X
  • Published: June 05, 2014
  • DOI: 10.1371/journal.pntd.0002882

About the Authors

Andrew Taylor Bright, Micah J. Manary, Tina Wang
Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, California, United States of America
Andrew Taylor Bright, Micah J. Manary, Elizabeth A. Winzeler
Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, United States of America
Ryan Tewhey, Nicholas J. Schork
Scripps Genomic Medicine, The Scripps Translational Science Institute, La Jolla, California, United States of America
Ryan Tewhey, Nicholas J. Schork
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
Eliana M. Arango
Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia
Stephanie K. Yanow
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Stephanie K. Yanow
Provincial Laboratory for Public Health, Edmonton, Alberta, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ATB RT SKY EAW. Performed the experiments: ATB RT EMA. Analyzed the data: ATB MJM EMA TW NJS SKY EAW. Contributed reagents/materials/analysis tools: MJM. Wrote the paper: ATB SKY EAW.