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Research Article

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

  • Juan P. Rigalli,

    Affiliations: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina, Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Virginia G. Perdomo,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Marcelo G. Luquita,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Silvina S. M. Villanueva,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Agostina Arias,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Dirk Theile,

    Affiliation: Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Johanna Weiss,

    Affiliation: Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Aldo D. Mottino,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • María L. Ruiz,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Viviana A. Catania mail

    vcatania@fbioyf.unr.edu.ar

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.pntd.0001951

About the Authors

Juan P. Rigalli, Virginia G. Perdomo, Marcelo G. Luquita, Silvina S. M. Villanueva, Agostina Arias, Aldo D. Mottino, María L. Ruiz, Viviana A. Catania
Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
Juan P. Rigalli, Dirk Theile, Johanna Weiss
Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

Corresponding Author

Email: vcatania@fbioyf.unr.edu.ar

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VAC ADM MLR. Performed the experiments: JPR VGP MGL SSMV AA DT. Analyzed the data: JPR VGP MGL SSMV AA DT JW ADM MLR VAC. Contributed reagents/materials/analysis tools: JW. Wrote the paper: JPR DT ADM MLR VAC.