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Research Article

Field Cage Studies and Progressive Evaluation of Genetically-Engineered Mosquitoes

  • Luca Facchinelli mail,

    luca.facchinelli@uniroma1.it (LF); twscott@ucdavis.edu (TWS)

    Affiliation: Department of Entomology, University of California Davis, Davis, California, United States of America

    X
  • Laura Valerio,

    Affiliations: Department of Entomology, University of California Davis, Davis, California, United States of America, Istituto Pasteur-Fondazione Cenci Bolognetti, Università la Sapienza, Rome, Italy

    X
  • Janine M. Ramsey,

    Affiliation: Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México

    X
  • Fred Gould,

    Affiliations: Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rachael K. Walsh,

    Affiliations: Department of Entomology, University of California Davis, Davis, California, United States of America, Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America

    X
  • Guillermo Bond,

    Affiliation: Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México

    X
  • Michael A. Robert,

    Affiliation: Biomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America

    X
  • Alun L. Lloyd,

    Affiliations: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, Biomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America

    X
  • Anthony A. James,

    Affiliation: Departments of Microbiology and Molecular Genetics and Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America

    X
  • Luke Alphey,

    Affiliations: Oxitec Ltd., Abingdon, Oxfordshire, United Kingdom, Department of Zoology, University of Oxford, Oxford, United Kingdom

    X
  • Thomas W. Scott mail

    luca.facchinelli@uniroma1.it (LF); twscott@ucdavis.edu (TWS)

    Affiliations: Department of Entomology, University of California Davis, Davis, California, United States of America, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: January 17, 2013
  • DOI: 10.1371/journal.pntd.0002001

About the Authors

Luca Facchinelli, Laura Valerio, Rachael K. Walsh, Thomas W. Scott
Department of Entomology, University of California Davis, Davis, California, United States of America
Laura Valerio
Istituto Pasteur-Fondazione Cenci Bolognetti, Università la Sapienza, Rome, Italy
Janine M. Ramsey, Guillermo Bond
Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México
Fred Gould, Rachael K. Walsh
Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America
Fred Gould, Alun L. Lloyd, Thomas W. Scott
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
Michael A. Robert, Alun L. Lloyd
Biomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, North Carolina, United States of America
Anthony A. James
Departments of Microbiology and Molecular Genetics and Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America
Luke Alphey
Oxitec Ltd., Abingdon, Oxfordshire, United Kingdom
Luke Alphey
Department of Zoology, University of Oxford, Oxford, United Kingdom

Corresponding Authors

Competing Interests

Luke Alphey is an employee of Oxitec Ltd, which provided salary and other support for the research program. Also, such employee has shares or share options in Oxitec Ltd. Both Oxitec Ltd. and Oxford University have one or more patents or patent applications related to the subject of this paper.

Author Contributions

Conceived and designed the experiments: LF LV TWS JMR GB FG LA AAJ. Performed the experiments: LF LV RKW. Analyzed the data: LV LF. Contributed reagents/materials/analysis tools: MAR ALL FG. Wrote the paper: LF LV TWS FG. Supervised research: TWS JMR AAJ. Revised the manuscript critically adding important intellectual content: AAJ. Acquisition of funding: AAJ.