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Research Article

Bispidine-Amino Acid Conjugates Act as a Novel Scaffold for the Design of Antivirals That Block Japanese Encephalitis Virus Replication

  • V. Haridas mail,

    haridasv@chemistry.iitd.ac.in (VH); gmedigeshi@thsti.res.in (GRM)

    Affiliation: Department of Chemistry, Indian Institute of Technology, New Delhi, India

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  • Kullampalayam Shanmugam Rajgokul,

    Affiliation: Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Gurgaon, India

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  • Sandhya Sadanandan,

    Affiliation: Department of Chemistry, Indian Institute of Technology, New Delhi, India

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  • Tanvi Agrawal,

    Affiliation: Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Gurgaon, India

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  • Vats Sharvani,

    Affiliation: Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Gurgaon, India

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  • M. V. S. Gopalakrishna,

    Affiliation: Department of Chemistry, Indian Institute of Technology, New Delhi, India

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  • M. B. Bijesh,

    Affiliation: Department of Chemistry, Indian Institute of Technology, New Delhi, India

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  • Kanhaiya Lal Kumawat,

    Affiliation: National Brain Research Center, Manesar, Haryana, India

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  • Anirban Basu,

    Affiliation: National Brain Research Center, Manesar, Haryana, India

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  • Guruprasad R. Medigeshi mail

    haridasv@chemistry.iitd.ac.in (VH); gmedigeshi@thsti.res.in (GRM)

    Affiliation: Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Gurgaon, India

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pntd.0002005

About the Authors

V. Haridas, Sandhya Sadanandan, M. V. S. Gopalakrishna, M. B. Bijesh
Department of Chemistry, Indian Institute of Technology, New Delhi, India
Kullampalayam Shanmugam Rajgokul, Tanvi Agrawal, Vats Sharvani, Guruprasad R. Medigeshi
Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Gurgaon, India
Kanhaiya Lal Kumawat, Anirban Basu
National Brain Research Center, Manesar, Haryana, India

Corresponding Authors

Competing Interests

Two patent applications are pending related to this study with provisional patent application numbers 2784/Del/2011 and 2786/Del/2011.

Author Contributions

Conceived and designed the experiments: VH GRM. Performed the experiments: KSR SS TA VS MVSG MBB KLK GRM. Analyzed the data: GRM VH. Contributed reagents/materials/analysis tools: AB. Wrote the paper: VH GRM.