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Research Article

Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

  • Simone Pieretti equal contributor,

    equal contributor Contributed equally to this work with: Simone Pieretti, Jurgen R. Haanstra

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland, Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Jurgen R. Haanstra equal contributor,

    equal contributor Contributed equally to this work with: Simone Pieretti, Jurgen R. Haanstra

    Affiliations: Department of Pediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Muriel Mazet,

    Affiliation: Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium

    Current address: Centre de Résonance Magnétique des Systèmes Biologiques (RMSB), UMR 5536 CNRS, Université Victor Segalen Bordeaux 2, Bordeaux, France

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  • Remo Perozzo,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

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  • Christian Bergamini,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Federica Prati,

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy

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  • Romana Fato,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Giorgio Lenaz,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Giovanni Capranico,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Reto Brun,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Barbara M. Bakker,

    Affiliations: Department of Pediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Paul A. M. Michels,

    Affiliation: Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium

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  • Leonardo Scapozza,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

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  • Maria Laura Bolognesi mail,

    marialaura.bolognesi@unibo.it (MLB); andrea.cavalli@unibo.it (AC)

    Affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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  • Andrea Cavalli mail

    marialaura.bolognesi@unibo.it (MLB); andrea.cavalli@unibo.it (AC)

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pntd.0002012

About the Authors

Simone Pieretti, Federica Prati, Maria Laura Bolognesi, Andrea Cavalli
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
Simone Pieretti, Remo Perozzo, Leonardo Scapozza
Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
Simone Pieretti, Christian Bergamini, Romana Fato, Giorgio Lenaz, Giovanni Capranico
Department of Biochemistry, University of Bologna, Bologna, Italy
Jurgen R. Haanstra, Barbara M. Bakker
Department of Pediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Jurgen R. Haanstra, Barbara M. Bakker
Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Muriel Mazet, Paul A. M. Michels
Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium
Federica Prati, Andrea Cavalli
Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy
Reto Brun
Swiss Tropical Institute, Basel, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RP PAMM MLB AC. Performed the experiments: SP JRH MM RP FP CB RB. Analyzed the data: JRH RP RF GL GC BMB PAMM LS MLB AC. Contributed reagents/materials/analysis tools: GL GC PAMM LS MLB AC. Wrote the paper: JRH PAAM MLB AC.