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Research Article

Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

  • Deepak V. Almeida,

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Paul J. Converse,

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Si-Yang Li,

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Sandeep Tyagi,

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Eric L. Nuermberger,

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Jacques H. Grosset mail

    jgrosse4@jhmi.edu

    Affiliation: Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pntd.0002085

About the Authors

Deepak V. Almeida, Paul J. Converse, Si-Yang Li, Sandeep Tyagi, Eric L. Nuermberger, Jacques H. Grosset
Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: jgrosse4@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DVA PJC JHG. Performed the experiments: DVA PJC SL ST. Analyzed the data: DVA PJC ELN JHG. Contributed reagents/materials/analysis tools: DVA JHG. Wrote the paper: DVA JHG.