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Research Article

Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis

  • Prasert Saichua,

    Affiliation: Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand

    X
  • Paiboon Sithithaworn mail,

    paib_sit@kku.ac.th (P. Sithithaworn); jbethony@gwu.edu (J.M. Bethony)

    Affiliations: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

    X
  • Amar R. Jariwala,

    Affiliation: Department of Microbiology, Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America

    X
  • David J. Deimert,

    Affiliation: Department of Microbiology, Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America

    X
  • Jiraporn Sithithaworn,

    Affiliation: Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand

    X
  • Banchob Sripa,

    Affiliation: Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

    X
  • Thewarach Laha,

    Affiliation: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

    X
  • Eimorn Mairiang,

    Affiliation: Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

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  • Chawalit Pairojkul,

    Affiliation: Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

    X
  • Maria Victoria Periago,

    Affiliation: Insituto René Rachou, Laboratório de Imunologia Celular e Molecular, Belo Horizonte, Brazil

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  • Narong Khuntikeo,

    Affiliation: Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

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  • Jason Mulvenna,

    Affiliation: Infections and Cancer, Queensland Institute of Medical Research, Queensland, Australia

    X
  • Jeffrey M. Bethony mail

    paib_sit@kku.ac.th (P. Sithithaworn); jbethony@gwu.edu (J.M. Bethony)

    Affiliation: Department of Microbiology, Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America

    X
  • Published: May 23, 2013
  • DOI: 10.1371/journal.pntd.0002228

About the Authors

Prasert Saichua
Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand
Paiboon Sithithaworn, Thewarach Laha
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Paiboon Sithithaworn
Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Amar R. Jariwala, David J. Deimert, Jeffrey M. Bethony
Department of Microbiology, Immunology and Tropical Medicine and Center for the Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America
Jiraporn Sithithaworn
Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
Banchob Sripa
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Eimorn Mairiang, Chawalit Pairojkul
Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Maria Victoria Periago
Insituto René Rachou, Laboratório de Imunologia Celular e Molecular, Belo Horizonte, Brazil
Narong Khuntikeo
Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Jason Mulvenna
Infections and Cancer, Queensland Institute of Medical Research, Queensland, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: P. Saichua, P. Sithithaworn, A.R. Jariwala, J. Sithithaworn, B. Sripa, E. Miarang, J.M. Bethony. Performed the experiments: P. Saichua, A.R. Jariwala, J. Sithithaworn, E. Mairiang, C. Pairojkul, N. Khuntikeo, J. Mulvenna, J.M. Bethony. Analyzed the data: P. Saichua, P. Sithithaworn, A.R. Jariwala, D.J. Deimert, J. Sithithaworn, B. Sripa, E. Mairiang, J. Mulvenna, J.M. Bethony. Contributed reagents/materials/analysis tools: P. Saichua, P. Sithithaworn, A.R. Jariwala, B. Sripa, E. Mairiang, C. Pairojkul, T. Laha, J. Mulevenna, C. Pairojkul, N. Khuntikeo, J.M. Bethony. Wrote the paper: P. Saichua, P. Sithithaworn, D.J. Deimert, B. Sripa, M.V. Periago, T. Laha, J. Mulvenna, J.M. Bethony.