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Table of Contents: August 2014

Issue Image

T. cruzi amastigotes expressing green fluorescence protein are green, cardiomyocyte nuclei are blue, and cardiomyocyte actin myofibrils are red. See Farrow et al.

Editorial

Visceral Leishmaniasis and HIV Coinfection: Time for Concerted Action

Johan van Griensven, Ed E. Zijlstra, Asrat Hailu

Viewpoints

Chronic Kidney Disease Epidemic in Central America: Urgent Public Health Action Is Needed amid Causal Uncertainty

Pedro Ordunez, Ramón Martinez, Ludovic Reveiz, Evelina Chapman, Carla Saenz, Agnes Soares da Silva, Francisco Becerra

Historical Profiles and Perspectives

International Glossina Genome Initiative 2004–2014: A Driver for Post-Genomic Era Research on the African Continent

Alan Christoffels, Dan Masiga, Matthew Berriman, Mike Lehane, Yeya Touré, Serap Aksoy

Symposium

Case Report of Two Cases of Fever, Rash, and Organ Involvement during the Treatment of Leprosy

Hong Liu, Chuan Wang, Tongsheng Chu, Parimi Leela Rani, Debao Yu, Xi'an Fu, Mingfei Chen, Shumin Chen, Furen Zhang

Reviews

Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions

James Whitehorn, Sophie Yacoub, Katherine L. Anders, Louis R. Macareo, M. Cristina Cassetti, Vinh Chau Nguyen Van, Pei-Yong Shi, Bridget Wills, Cameron P. Simmons

How Far Are We from Visceral Leishmaniasis Elimination in Bangladesh? An Assessment of Epidemiological Surveillance Data

Rajib Chowdhury, Dinesh Mondal, Vashkar Chowdhury, Shyla Faria, Jorge Alvar, Shah Golam Nabi, Marleen Boelaert, Aditya Prasad Dash

Visceral Leishmaniasis and HIV Coinfection in the Mediterranean Region

Begoña Monge-Maillo, Francesca F. Norman, Israel Cruz, Jorge Alvar, Rogelio López-Vélez

Vaccine Strategies for the Control and Prevention of Japanese Encephalitis in Mainland China, 1951–2011

Xiaoyan Gao, Xiaolong Li, Minghua Li, Shihong Fu, Huanyu Wang, Zhi Lu, Yuxi Cao, Ying He, Wuyang Zhu, Tingting Zhang, Ernest A. Gould, Guodong Liang

Strongyloidiasis—An Insight into Its Global Prevalence and Management

Santhosh Puthiyakunnon, Swapna Boddu, Yiji Li, Xiaohong Zhou, Chunmei Wang, Juan Li, Xiaoguang Chen

A Screen-and-Treat Strategy Targeting Visceral Leishmaniasis in HIV-Infected Individuals in Endemic East African Countries: The Way Forward?

Johan van Griensven, Ermias Diro, Rogelio Lopez-Velez, Koert Ritmeijer, Marleen Boelaert, Ed E. Zijlstra, Asrat Hailu, Lutgarde Lynen

Research Articles

The Prawn Macrobrachium vollenhovenii in the Senegal River Basin: Towards Sustainable Restocking of All-Male Populations for Biological Control of Schistosomiasis

Amit Savaya Alkalay, Ohad Rosen, Susanne H. Sokolow, Yacinthe P. W. Faye, Djibril S. Faye, Eliahu D. Aflalo, Nicolas Jouanard, Dina Zilberg, Elizabeth Huttinger, Amir Sagi

A Single Crossing-Over Event in Voltage-Sensitive Na+ Channel Genes May Cause Critical Failure of Dengue Mosquito Control by Insecticides

Koichi Hirata, Osamu Komagata, Kentaro Itokawa, Atsushi Yamamoto, Takashi Tomita, Shinji Kasai

Prevalence and Risk Factors for Echinococcal Infection in a Rural Area of Northern Chile: A Household-Based Cross-Sectional Study

Gerardo Acosta-Jamett, Thomas Weitzel, Belgees Boufana, Claudia Adones, Andrea Bahamonde, Katia Abarca, Philip S. Craig, Ingrid Reiter-Owona

Co-evolution between an Endosymbiont and Its Nematode Host: Wolbachia Asymmetric Posterior Localization and AP Polarity Establishment

Frederic Landmann, Jeremy M. Foster, Michelle L. Michalski, Barton E. Slatko, William Sullivan

Characterisation of a Plancitoxin-1-Like DNase II Gene in Trichinella spiralis

Chengshui Liao, Mingyuan Liu, Xue Bai, Pan Liu, Xuelin Wang, Tingting Li, Bin Tang, He Gao, Qingsong Sun, Xidong Liu, Ying Zhao, Feng Wang, Xiuping Wu, Pascal Boireau, Xiaolei Liu

Non-Participation during Azithromycin Mass Treatment for Trachoma in The Gambia: Heterogeneity and Risk Factors

Tansy Edwards, Elizabeth Allen, Emma M. Harding-Esch, John Hart, Sarah E. Burr, Martin J. Holland, Ansumana Sillah, Sheila K. West, David Mabey, Robin Bailey

Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia

Susana Barbosa, Amanda B. Gozze, Nathália F. Lima, Camilla L. Batista, Melissa da Silva Bastos, Vanessa C. Nicolete, Pablo S. Fontoura, Raquel M. Gonçalves, Susana Ariane S. Viana, Maria José Menezes, Kézia Katiani G. Scopel, Carlos E. Cavasini, Rosely dos Santos Malafronte, Mônica da Silva-Nunes, Joseph M. Vinetz, Márcia C. Castro, Marcelo U. Ferreira

Sporotrichosis: An Emerging Neglected Opportunistic Infection in HIV-Infected Patients in Rio de Janeiro, Brazil

Dayvison Francis Saraiva Freitas, Antonio Carlos Francesconi do Valle, Margarete Bernardo Tavares da Silva, Dayse Pereira Campos, Marcelo Rosandiski Lyra, Rogerio Valls de Souza, Valdiléa Gonçalves Veloso, Rosely Maria Zancopé-Oliveira, Francisco Inácio Bastos, Maria Clara Gutierrez Galhardo

Paracoccidioides lutzii Plp43 Is an Active Glucanase with Partial Antigenic Identity with P. brasiliensis gp43

Natanael P. Leitão Jr, Milene C. Vallejo, Palloma M. Conceição, Zoilo P. Camargo, Rosane Hahn, Rosana Puccia

Toxocariasis in North America: A Systematic Review

Rachel M. Lee, Laura B. Moore, Maria Elena Bottazzi, Peter J. Hotez

Optimized Multilocus Sequence Typing (MLST) Scheme for Trypanosoma cruzi

Patricio Diosque, Nicolás Tomasini, Juan José Lauthier, Louisa Alexandra Messenger, María Mercedes Monje Rumi, Paula Gabriela Ragone, Anahí Maitén Alberti-D'Amato, Cecilia Pérez Brandán, Christian Barnabé, Michel Tibayrenc, Michael David Lewis, Martin Stephen Llewellyn, Michael Alexander Miles, Matthew Yeo

Viral Aetiology of Central Nervous System Infections in Adults Admitted to a Tertiary Referral Hospital in Southern Vietnam over 12 Years

Le Van Tan, Le Hong Thai, Nguyen Hoan Phu, Ho Dang Trung Nghia, Ly Van Chuong, Dinh Xuan Sinh, Nguyen Duy Phong, Nguyen Thi Hoang Mai, Dinh Nguyen Huy Man, Vo Minh Hien, Nguyen Thanh Vinh, Jeremy Day, Nguyen Van Vinh Chau, Tran Tinh Hien, Jeremy Farrar, Menno D. de Jong, Guy Thwaites, H. Rogier van Doorn, Tran Thi Hong Chau

Presence of Antigen-Experienced T Cells with Low Grade of Differentiation and Proliferative Potential in Chronic Chagas Disease Myocarditis

Rafael J. Argüello, Carlos Vigliano, Patricia Cabeza-Meckert, Rodolfo Viotti, Fernando Garelli, Liliana E. Favaloro, Roberto R. Favaloro, Rubén Laguens, Susana A. Laucella

A Panel of Trypanosoma brucei Strains Tagged with Blue and Red-Shifted Luciferases for Bioluminescent Imaging in Murine Infection Models

Nick Van Reet, Hélène Van de Vyver, Patient Pati Pyana, Anne Marie Van der Linden, Philippe Büscher

Epidemiology of Intestinal Polyparasitism among Orang Asli School Children in Rural Malaysia

Ahmed K. Al-Delaimy, Hesham M. Al-Mekhlafi, Nabil A. Nasr, Hany Sady, Wahib M. Atroosh, Mohammed Nashiry, Tengku S. Anuar, Norhayati Moktar, Yvonne A. L. Lim, Rohela Mahmud

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses

Daniel T. Leung, Taufiqur R. Bhuiyan, Naoshin S. Nishat, Mohammad Rubel Hoq, Amena Aktar, M. Arifur Rahman, Taher Uddin, Ashraful I. Khan, Fahima Chowdhury, Richelle C. Charles, Jason B. Harris, Stephen B. Calderwood, Firdausi Qadri, Edward T. Ryan

Immunization with Hexon Modified Adenoviral Vectors Integrated with gp83 Epitope Provides Protection against Trypanosoma cruzi Infection

Anitra L. Farrow, Girish Rachakonda, Linlin Gu, Valentina Krendelchtchikova, Pius N. Nde, Siddharth Pratap, Maria F. Lima, Fernando Villalta, Qiana L. Matthews

HIV-Associated Histoplasmosis Early Mortality and Incidence Trends: From Neglect to Priority

Antoine Adenis, Mathieu Nacher, Matthieu Hanf, Vincent Vantilcke, Rachida Boukhari, Denis Blachet, Magalie Demar, Christine Aznar, Bernard Carme, Pierre Couppie

Mycetoma: Experience of 482 Cases in a Single Center in Mexico

Alexandro Bonifaz, Andrés Tirado-Sánchez, Luz Calderón, Amado Saúl, Javier Araiza, Marco Hernández, Gloria M. González, Rosa María Ponce

Isolation and Characterization of Two Novel Plasmids from Pathogenic Leptospira interrogans Serogroup Canicola Serovar Canicola Strain Gui44

Wei-Nan Zhu, Li-Li Huang, Ling-Bing Zeng, Xu-Ran Zhuang, Chun-Yan Chen, Yan-Zhuo Wang, Jin-Hong Qin, Yong-Zhang Zhu, Xiao-Kui Guo

Characterization of Digestive Involvement in Patients with Chronic T. cruzi Infection in Barcelona, Spain

María-Jesús Pinazo, Gloria Lacima, José-Ignacio Elizalde, Elizabeth-Jesús Posada, Fausto Gimeno, Edelweiss Aldasoro, María-Eugenia Valls, Joaquim Gascon

Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Jianxin Wang, Feifan Xu, Dandan Zhu, Yinong Duan, Jinling Chen, Xiaolei Sun, Xue He, Pan Li, Wei Sun, Jinrong Feng

Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection

Barbara C. Figueiredo, Natan R. G. Assis, Suellen B. Morais, Natasha D. Ricci, Carina S. Pinheiro, Vicente P. Martins, Rodrigo M. Bicalho, Akram A. Da'dara, Patrick J. Skelly, Sergio C. Oliveira

Ex-ante Benefit-Cost Analysis of the Elimination of a Glossina palpalis gambiensis Population in the Niayes of Senegal

Fanny Bouyer, Momar Talla Seck, Ahmadou H. Dicko, Baba Sall, Mbargou Lo, Marc J. B. Vreysen, Eduardo Chia, Jérémy Bouyer, Abdrahmane Wane

Effects of a Post-Deworming Health Hygiene Education Intervention on Absenteeism in School-Age Children of the Peruvian Amazon

François L. Thériault, Mathieu Maheu-Giroux, Brittany Blouin, Martin Casapía, Theresa W. Gyorkos

Distribution of Schistosomiasis and Soil Transmitted Helminthiasis in Zimbabwe: Towards a National Plan of Action for Control and Elimination

Nicholas Midzi, Takafira Mduluza, Moses J. Chimbari, Clement Tshuma, Lincoln Charimari, Gibson Mhlanga, Portia Manangazira, Shungu M. Munyati, Isaac Phiri, Susan L. Mutambu, Stanley S. Midzi, Anastancia Ncube, Lawrence P. Muranzi, Simbarashe Rusakaniko, Francisca Mutapi

Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths

Li-Li Xu, Bin Jiang, Ji-Hui Duan, Shi-Feng Zhuang, Yong-Chun Liu, Shi-Qiao Zhu, Li-Ping Zhang, Hao-Bing Zhang, Shu-Hua Xiao, Xiao-Nong Zhou

Long-term Sonographic and Serological Follow-up of Inactive Echinococcal Cysts of the Liver: Hints for a “Watch-and-Wait” Approach

Luca Piccoli, Francesca Tamarozzi, Federico Cattaneo, Mara Mariconti, Carlo Filice, Antonella Bruno, Enrico Brunetti

Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus

Christian A. Keller, Matthias Hauptmann, Julia Kolbaum, Mohammad Gharaibeh, Melanie Neumann, Markus Glatzel, Bernhard Fleischer

Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis

Cho Naing, Maxine A. Whittaker, Victor Nyunt Wai, Joon Wah Mak

Neglected Tropical Diseases: A Systematic Evaluation of Research Capacity in Nigeria

Patricia N. Okorie, Moses J. Bockarie, David H. Molyneux, Louise A. Kelly-Hope

Nitric Oxide from IFNγ-Primed Macrophages Modulates the Antimicrobial Activity of β-Lactams against the Intracellular Pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella

Jessica Jones-Carson, Adrienne E. Zweifel, Timothy Tapscott, Chad Austin, Joseph M. Brown, Kenneth L. Jones, Martin I. Voskuil, Andrés Vázquez-Torres

Disease Progression in Plasmodium knowlesi Malaria Is Linked to Variation in Invasion Gene Family Members

Atique M. Ahmed, Miguel M. Pinheiro, Paul C. Divis, Angela Siner, Ramlah Zainudin, Ing Tien Wong, Chan Woon Lu, Sarina K. Singh-Khaira, Scott B. Millar, Sean Lynch, Matthias Willmann, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh

Molecular Xenomonitoring Using Mosquitoes to Map Lymphatic Filariasis after Mass Drug Administration in American Samoa

Mark A. Schmaedick, Amanda L. Koppel, Nils Pilotte, Melissa Torres, Steven A. Williams, Stephen L. Dobson, Patrick J. Lammie, Kimberly Y. Won

MicroRNA-30e* Suppresses Dengue Virus Replication by Promoting NF-κB–Dependent IFN Production

Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li

A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

William J. Weise, Meghan E. Hermance, Naomi Forrester, A. Paige Adams, Rose Langsjoen, Rodion Gorchakov, Eryu Wang, Maria D. H. Alcorn, Konstantin Tsetsarkin, Scott C. Weaver

Neuropathogenesis of Japanese Encephalitis in a Primate Model

Khin Saw Aye Myint, Anja Kipar, Richard G. Jarman, Robert V. Gibbons, Guey Chuen Perng, Brian Flanagan, Duangrat Mongkolsirichaikul, Yvonne Van Gessel, Tom Solomon

Development of a Rapid Serological Assay for the Diagnosis of Strongyloidiasis Using a Novel Diffraction-Based Biosensor Technology

Brian J. Pak, Fabio Vasquez-Camargo, Evgeniya Kalinichenko, Peter L. Chiodini, Thomas B. Nutman, Herbert B. Tanowitz, Isabel McAuliffe, Patricia Wilkins, Paul T. Smith, Brian J. Ward, Michael D. Libman, Momar Ndao

Patterns of Geographic Expansion of Aedes aegypti in the Peruvian Amazon

Sarah Anne Guagliardo, José Luis Barboza, Amy C. Morrison, Helvio Astete, Gonzalo Vazquez-Prokopec, Uriel Kitron

Empiric Deworming and CD4 Count Recovery in HIV-Infected Ugandans Initiating Antiretroviral Therapy

Alexander J. Lankowski, Alexander C. Tsai, Michael Kanyesigye, Mwebesa Bwana, Jessica E. Haberer, Megan Wenger, Jeffrey N. Martin, David R. Bangsberg, Peter W. Hunt, Mark J. Siedner

Shifting Patterns of Aedes aegypti Fine Scale Spatial Clustering in Iquitos, Peru

Genevieve LaCon, Amy C. Morrison, Helvio Astete, Steven T. Stoddard, Valerie A. Paz-Soldan, John P. Elder, Eric S. Halsey, Thomas W. Scott, Uriel Kitron, Gonzalo M. Vazquez-Prokopec

Viper and Cobra Venom Neutralization by Alginate Coated Multicomponent Polyvalent Antivenom Administered by the Oral Route

Sourav Bhattacharya, Mousumi Chakraborty, Piyasi Mukhopadhyay, P. P. Kundu, Roshnara Mishra

Heterogeneous Feeding Patterns of the Dengue Vector, Aedes aegypti, on Individual Human Hosts in Rural Thailand

Laura C. Harrington, Andrew Fleisher, Diego Ruiz-Moreno, Francoise Vermeylen, Chrystal V. Wa, Rebecca L. Poulson, John D. Edman, John M. Clark, James W. Jones, Sangvorn Kitthawee, Thomas W. Scott

CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1

Laura J. Appleby, Norman Nausch, Louise Erskine, Claire D. Bourke, Nadine Rujeni, Nicholas Midzi, Takafira Mduluza, Francisca Mutapi

Visceral Leishmaniasis and HIV Co-infection in Bihar, India: Long-term Effectiveness and Treatment Outcomes with Liposomal Amphotericin B (AmBisome)

Sakib Burza, Raman Mahajan, Prabhat K. Sinha, Johan van Griensven, Krishna Pandey, María Angeles Lima, Marta Gonzalez Sanz, Temmy Sunyoto, Sunil Kumar, Gaurab Mitra, Ranjeet Kumar, Neena Verma, Pradeep Das

Emergence of Coxiella burnetii in Ruminants on Reunion Island? Prevalence and Risk Factors

Eric Cardinale, Olivier Esnault, Marina Beral, Florence Naze, Alain Michault

Toward Understanding the Functional Role of Ss-riok-1, a RIO Protein Kinase-Encoding Gene of Strongyloides stercoralis

Wang Yuan, James B. Lok, Jonathan D. Stoltzfus, Robin B. Gasser, Fang Fang, Wei-Qiang Lei, Rui Fang, Yan-Qin Zhou, Jun-Long Zhao, Min Hu

Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen

José B. Gama, Steffen Ohlmeier, Teresa G. Martins, Alexandra G. Fraga, Belém Sampaio-Marques, Maria A. Carvalho, Fernanda Proença, Manuel T. Silva, Jorge Pedrosa, Paula Ludovico

Identification of Tick-Borne Pathogens in Ticks Feeding on Humans in Turkey

Ömer Orkun, Zafer Karaer, Ayşe Çakmak, Serpil Nalbantoğlu

Simulating Population Genetics of Pathogen Vectors in Changing Landscapes: Guidelines and Application with Triatoma brasiliensis

Francois Rebaudo, Jane Costa, Carlos E. Almeida, Jean-Francois Silvain, Myriam Harry, Olivier Dangles

Cystic Echinococcosis in the Province of Álava, North Spain: The Monetary Burden of a Disease No Longer under Surveillance

Hélène Carabin, Francisco J. Balsera-Rodríguez, José Rebollar-Sáenz, Christine T. Benner, Aitziber Benito, Juan C. Fernández-Crespo, David Carmena

Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi

Felipe Gazos-Lopes, Mauricio M. Oliveira, Lucas V. B. Hoelz, Danielle P. Vieira, Alexandre F. Marques, Ernesto S. Nakayasu, Marta T. Gomes, Nasim G. Salloum, Pedro G. Pascutti, Thaïs Souto-Padrón, Robson Q. Monteiro, Angela H. Lopes, Igor C. Almeida

Cytokine Responses to Schistosoma mansoni and Schistosoma haematobium in Relation to Infection in a Co-endemic Focus in Northern Senegal

Lynn Meurs, Moustapha Mbow, Nele Boon, Kim Vereecken, Abena Serwaa Amoah, Lucja A. Labuda, Tandakha Ndiaye Dièye, Souleymane Mboup, Maria Yazdanbakhsh, Katja Polman

Toxocara Seroprevalence among Clinically Healthy Individuals, Pregnant Women and Psychiatric Patients and Associated Risk Factors in Shandong Province, Eastern China

Wei Cong, Xiao-Xuan Zhang, Na Zhou, Chang-Zheng Yu, Jia Chen, Xiang-Yang Wang, Bing Li, Ai-Dong Qian, Xing-Quan Zhu

Suppressing Dengue-2 Infection by Chemical Inhibition of Aedes aegypti Host Factors

Seokyoung Kang, Alicia R. Shields, Natapong Jupatanakul, George Dimopoulos

Corrections