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Table of Contents: July 2014

Issue Image

Daily cleaning of personnel boots and gloves at the Ebola treatment center in Gueckedou, Guinea. See Bausch and Schwarz.

Editorial

Viewpoints

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

Peter J. Hotez, Miriam Alvarado, María-Gloria Basáñez, Ian Bolliger, Rupert Bourne, Michel Boussinesq, Simon J. Brooker, Ami Shah Brown, Geoffrey Buckle, Christine M. Budke, Hélène Carabin, Luc E. Coffeng, Eric M. Fèvre, Thomas Fürst, Yara A. Halasa, Rashmi Jasrasaria, Nicole E. Johns, Jennifer Keiser, Charles H. King, Rafael Lozano, Michele E. Murdoch, Simon O'Hanlon, Sébastien D. S. Pion, Rachel L. Pullan, Kapa D. Ramaiah, Thomas Roberts, Donald S. Shepard, Jennifer L. Smith, Wilma A. Stolk, Eduardo A. Undurraga, Jürg Utzinger, Mengru Wang, Christopher J. L. Murray, Mohsen Naghavi

Visceral Leishmaniasis as an AIDS Defining Condition: Towards Consistency across WHO Guidelines

Johan van Griensven, Koert Ritmeijer, Lutgarde Lynen, Ermias Diro

Policy Platform

Introducing a Dengue Vaccine to Mexico: Development of a System for Evidence-Based Public Policy Recommendations

Miguel Betancourt-Cravioto, Pablo Kuri-Morales, Jesús Felipe González-Roldán, Roberto Tapia-Conyer , the Mexican Dengue Expert Group

Historical Profiles and Perspectives

Haiti National Program for the Elimination of Lymphatic Filariasis—A Model of Success in the Face of Adversity

Roland Oscar, Jean Frantz Lemoine, Abdel Nasser Direny, Luccene Desir, Valery E. Madsen Beau de Rochars, Mathieu J. P. Poirier, Ann Varghese, Ijeoma Obidegwu, Patrick J. Lammie, Thomas G. Streit, Marie Denise Milord

Reviews

Acute Chagas Disease: New Global Challenges for an Old Neglected Disease

Daniela V. Andrade, Kenneth J. Gollob, Walderez O. Dutra

Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

Marie J. Ducrotoy, Wilson J. Bertu, Reuben A. Ocholi, Amahyel M. Gusi, Ward Bryssinckx, Sue Welburn, Ignacio Moriyón

Oroya Fever and Verruga Peruana: Bartonelloses Unique to South America

Michael F. Minnick, Burt E. Anderson, Amorce Lima, James M. Battisti, Phillip G. Lawyer, Richard J. Birtles

Immune Regulation during Chronic Visceral Leishmaniasis

Rebecca J. Faleiro, Rajiv Kumar, Louise M. Hafner, Christian R. Engwerda

Merits and Pitfalls of Currently Used Diagnostic Tools in Mycetoma

Wendy W. J. van de Sande, Ahmed H. Fahal, Michael Goodfellow, El Sheikh Mahgoub, Oliverio Welsh, Ed E. Zijlstra

Research Articles

Seroprevalence of Alphavirus Antibodies in a Cross-Sectional Study in Southwestern Tanzania Suggests Endemic Circulation of Chikungunya

Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich

Evidence of Experimental Vertical Transmission of Emerging Novel ECSA Genotype of Chikungunya Virus in Aedes aegypti

Ankita Agarwal, Paban Kumar Dash, Anil Kumar Singh, Shashi Sharma, Natarajan Gopalan, Putcha Venkata Lakshmana Rao, Man Mohan Parida, Paul Reiter

Facial Structure Alterations and Abnormalities of the Paranasal Sinuses on Multidetector Computed Tomography Scans of Patients with Treated Mucosal Leishmaniasis

Raphael Abegão de Camargo, Antonio C. Nicodemo, Daniel Vaccaro Sumi, Eloisa Maria Mello Santiago Gebrim, Felipe Francisco Tuon, Lázaro Manoel de Camargo, Rui Imamura, Valdir Sabbaga Amato

Increased Interleukin-17 in Peripheral Blood and Cerebrospinal Fluid of Neurosyphilis Patients

Cuini Wang, Lin Zhu, Zixiao Gao, Zhifang Guan, Haikong Lu, Mei Shi, Ying Gao, Huanbin Xu, X. Frank Yang, Pingyu Zhou

Origin of the Dengue Fever Mosquito, Aedes aegypti, in California

Andrea Gloria-Soria, Julia E. Brown, Vicki Kramer, Melissa Hardstone Yoshimizu, Jeffrey R. Powell

Co-occurrence of Point Mutations in the Voltage-Gated Sodium Channel of Pyrethroid-Resistant Aedes aegypti Populations in Myanmar

Hitoshi Kawada, Sai Zaw Min Oo, Sein Thaung, Emiko Kawashima, Yan Naung Maung Maung, Hlaing Myat Thu, Kyaw Zin Thant, Noboru Minakawa

Patterns and Risks of Trichinella Infection in Humans and Pigs in Northern Laos

James V. Conlan, Khamphouth Vongxay, Boualam Khamlome, Maria Angeles Gomez-Morales, Edoardo Pozio, Stuart D. Blacksell, Stanley Fenwick, R. C. A. Thompson

Serological Surveillance Development for Tropical Infectious Diseases Using Simultaneous Microsphere-Based Multiplex Assays and Finite Mixture Models

Yoshito Fujii, Satoshi Kaneko, Samson Muuo Nzou, Matilu Mwau, Sammy M. Njenga, Chihiro Tanigawa, James Kimotho, Anne Wanjiru Mwangi, Ibrahim Kiche, Sohkichi Matsumoto, Mamiko Niki, Mayuko Osada-Oka, Yoshio Ichinose, Manabu Inoue, Makoto Itoh, Hiroshi Tachibana, Kazunari Ishii, Takafumi Tsuboi, Lay Myint Yoshida, Dinesh Mondal, Rashidul Haque, Shinjiro Hamano, Mwatasa Changoma, Tomonori Hoshi, Ken-ichi Kamo, Mohamed Karama, Masashi Miura, Kenji Hirayama

An Integrated Lab-on-Chip for Rapid Identification and Simultaneous Differentiation of Tropical Pathogens

Jeslin J. L. Tan, Monica Capozzoli, Mitsuharu Sato, Wanitda Watthanaworawit, Clare L. Ling, Marjorie Mauduit, Benoît Malleret, Anne-Charlotte Grüner, Rosemary Tan, François H. Nosten, Georges Snounou, Laurent Rénia, Lisa F. P. Ng

Evidence for Circulation of the Rift Valley Fever Virus among Livestock in the Union of Comoros

Matthieu Roger, Marina Beral, Séverine Licciardi, Miradje Soulé, Abdourahime Faharoudine, Coralie Foray, Marie-Marie Olive, Marianne Maquart, Abdouroihamane Soulaimane, Ahmed Madi Kassim, Catherine Cêtre-Sossah, Eric Cardinale

Characterization of Enteroviruses from Non-Human Primates in Cameroon Revealed Virus Types Widespread in Humans along with Candidate New Types and Species

Serge Alain Sadeuh-Mba, Maël Bessaud, Marie-Line Joffret, Marie-Claire Endegue Zanga, Jean Balanant, Eitel Mpoudi Ngole, Richard Njouom, Jean-Marc Reynes, Francis Delpeyroux, Dominique Rousset

Treatment of Tungiasis with Dimeticone: A Proof-of-Principle Study in Rural Kenya

Marlene Thielecke, Per Nordin, Nicholas Ngomi, Hermann Feldmeier

Predicted Impact of Mass Drug Administration on the Development of Protective Immunity against Schistosoma haematobium

Kate M. Mitchell, Francisca Mutapi, Takafira Mduluza, Nicholas Midzi, Nicholas J. Savill, Mark E. J. Woolhouse

Transcriptional Correlates of Disease Outcome in Anticoagulant-Treated Non-Human Primates Infected with Ebolavirus

Sara Garamszegi, Judy Y. Yen, Anna N. Honko, Joan B. Geisbert, Kathleen H. Rubins, Thomas W. Geisbert, Yu Xia, Lisa E. Hensley, John H. Connor

Risk of Dengue for Tourists and Teams during the World Cup 2014 in Brazil

Willem G. van Panhuis, Sangwon Hyun, Kayleigh Blaney, Ernesto T. A. Marques Jr, Giovanini E. Coelho, João Bosco Siqueira Jr, Ryan Tibshirani, Jarbas B. da Silva Jr, Roni Rosenfeld

Bat Rabies in Guatemala

James A. Ellison, Amy T. Gilbert, Sergio Recuenco, David Moran, Danilo A. Alvarez, Natalia Kuzmina, Daniel L. Garcia, Leonard F. Peruski, Mary T. Mendonça, Kim A. Lindblade, Charles E. Rupprecht

Unsuspected Leptospirosis Is a Cause of Acute Febrile Illness in Nicaragua

Megan E. Reller, Elsio A. Wunder Jr, Jeremy J. Miles, Judith E. Flom, Orlando Mayorga, Christopher W. Woods, Albert I. Ko, J. Stephen Dumler, Armando J. Matute

A Novel MVA Vectored Chikungunya Virus Vaccine Elicits Protective Immunity in Mice

James Weger-Lucarelli, Haiyan Chu, Matthew T. Aliota, Charalambos D. Partidos, Jorge E. Osorio

Transmission and Control of Plasmodium knowlesi: A Mathematical Modelling Study

Natsuko Imai, Michael T. White, Azra C. Ghani, Chris J. Drakeley

The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India

Moataz Abd El Ghany, Jagadish Chander, Ankur Mutreja, Mamoon Rashid, Grant A. Hill-Cawthorne, Shahjahan Ali, Raeece Naeem, Nicholas R. Thomson, Gordon Dougan, Arnab Pain

Risk Factors for Adverse Prognosis and Death in American Visceral Leishmaniasis: A Meta-analysis

Vinícius Silva Belo, Claudio José Struchiner, David Soeiro Barbosa, Bruno Warlley Leandro Nascimento, Marco Aurélio Pereira Horta, Eduardo Sérgio da Silva, Guilherme Loureiro Werneck

MALDI-TOF Mass Spectrometry Detection of Pathogens in Vectors: The Borrelia crocidurae/Ornithodoros sonrai Paradigm

Aurélien Fotso Fotso, Oleg Mediannikov, Georges Diatta, Lionel Almeras, Christophe Flaudrops, Philippe Parola, Michel Drancourt

Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School Children in Mbita District, Western Kenya

Sachiyo Nagi, Evans A. Chadeka, Toshihiko Sunahara, Faith Mutungi, Yombo K. Dan Justin, Satoshi Kaneko, Yoshio Ichinose, Sohkichi Matsumoto, Sammy M. Njenga, Masahiro Hashizume, Masaaki Shimada, Shinjiro Hamano

Cross-sectional Study of the Burden of Vector-Borne and Soil-Transmitted Polyparasitism in Rural Communities of Coast Province, Kenya

Donal Bisanzio, Francis Mutuku, Amaya L. Bustinduy, Peter L. Mungai, Eric M. Muchiri, Charles H. King, Uriel Kitron

IrSPI, a Tick Serine Protease Inhibitor Involved in Tick Feeding and Bartonella henselae Infection

Xiang Ye Liu, Jose de la Fuente, Martine Cote, Ruth C. Galindo, Sara Moutailler, Muriel Vayssier-Taussat, Sarah I. Bonnet

Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus Replication

Melanie McFarlane, Camilo Arias-Goeta, Estelle Martin, Zoe O'Hara, Aleksei Lulla, Laurence Mousson, Stephanie M. Rainey, Suzana Misbah, Esther Schnettler, Claire L. Donald, Andres Merits, Alain Kohl, Anna-Bella Failloux

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process

María C. Merino, Nahuel Zamponi, Cecilia V. Vranych, María C. Touz, Andrea S. Rópolo

Serological, Molecular and Entomological Surveillance Demonstrates Widespread Circulation of West Nile Virus in Turkey

Koray Ergunay, Filiz Gunay, Ozge Erisoz Kasap, Kerem Oter, Sepandar Gargari, Taner Karaoglu, Seda Tezcan, Mehmet Cabalar, Yakup Yildirim, Gürol Emekdas, Bulent Alten, Aykut Ozkul

The Incidence of Japanese Encephalitis in Taiwan—A Population-Based Study

Li-Ching Hsu, Yu-Ju Chen, Feng-Kuang Hsu, Jyh-Hsiung Huang, Chi-Ming Chang, Pesus Chou, I-Feng Lin, Feng-Yee Chang

Ocular Pentastomiasis in the Democratic Republic of the Congo

Mihály Sulyok, Lajos Rózsa, Imre Bodó, Dennis Tappe, Richard Hardi

Burden of Diarrhea, Hospitalization and Mortality Due to Cryptosporidial Infections in Indian Children

Rajiv Sarkar, Jacqueline E. Tate, Sitara S. R. Ajjampur, Deepthi Kattula, Jacob John, Honorine D. Ward, Gagandeep Kang

Monitoring Antigenic Variations of Enterovirus 71: Implications for Virus Surveillance and Vaccine Development

Min-Yuan Chia, Wan-Yu Chung, Pai-Shan Chiang, Yeh-Sheng Chien, Mei-Shang Ho, Min-Shi Lee

Detection of Circulating Parasite-Derived MicroRNAs in Filarial Infections

Lucienne Tritten, Erica Burkman, Andrew Moorhead, Mohammed Satti, James Geary, Charles Mackenzie, Timothy Geary

Eosinophil Granule Proteins ECP and EPX as Markers for a Potential Early-Stage Inflammatory Lesion in Female Genital Schistosomiasis (FGS)

Charles Emile Ramarokoto, Anna Overgaard Kildemoes, Bodo Sahondra Randrianasolo, Pascaline Ravoniarimbinina, Vololomboahangy Elisabeth Ravaoalimalala, Peter Leutscher, Eyrun Floerecke Kjetland, Birgitte Jyding Vennervald

Praziquantel, Mefloquine-Praziquantel, and Mefloquine-Artesunate-Praziquantel against Schistosoma haematobium: A Randomized, Exploratory, Open-Label Trial

Jennifer Keiser, Kigbafori D. Silué, Lukas K. Adiossan, Nicaise A. N'Guessan, N'Chou Monsan, Jürg Utzinger, Eliézer K. N'Goran

Identification of sVSG117 as an Immunodiagnostic Antigen and Evaluation of a Dual-Antigen Lateral Flow Test for the Diagnosis of Human African Trypanosomiasis

Lauren Sullivan, Jennifer Fleming, Lalitha Sastry, Angela Mehlert, Steven J. Wall, Michael A. J. Ferguson

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

Joseph D. Planer, Matthew A. Hulverson, Jennifer A. Arif, Ranae M. Ranade, Robert Don, Frederick S. Buckner

Changing Patterns of Human Anthrax in Azerbaijan during the Post-Soviet and Preemptive Livestock Vaccination Eras

Ian Kracalik, Rakif Abdullayev, Kliment Asadov, Rita Ismayilova, Mehriban Baghirova, Narmin Ustun, Mazahir Shikhiyev, Aydin Talibzade, Jason K. Blackburn

Serology of Paracoccidioidomycosis Due to Paracoccidioides lutzii

Gregory Gegembauer, Leticia Mendes Araujo, Edy Firmina Pereira, Anderson Messias Rodrigues, Anamaria Mello Miranda Paniago, Rosane Christine Hahn, Zoilo Pires de Camargo

Neurocognitive Outcome of Children Exposed to Perinatal Mother-to-Child Chikungunya Virus Infection: The CHIMERE Cohort Study on Reunion Island

Patrick Gérardin, Sylvain Sampériz, Duksha Ramful, Brahim Boumahni, Marc Bintner, Jean-Luc Alessandri, Magali Carbonnier, Isabelle Tiran-Rajaoefera, Gilles Beullier, Irénée Boya, Tahir Noormahomed, Jocelyn Okoï, Olivier Rollot, Liliane Cotte, Marie-Christine Jaffar-Bandjee, Alain Michault, François Favier, Monique Kaminski, Alain Fourmaintraux, Xavier Fritel

Long-Term and Seasonal Dynamics of Dengue in Iquitos, Peru

Steven T. Stoddard, Helen J. Wearing, Robert C. Reiner Jr, Amy C. Morrison, Helvio Astete, Stalin Vilcarromero, Carlos Alvarez, Cesar Ramal-Asayag, Moises Sihuincha, Claudio Rocha, Eric S. Halsey, Thomas W. Scott, Tadeusz J. Kochel, Brett M. Forshey

Transcriptome Sequencing and Developmental Regulation of Gene Expression in Anopheles aquasalis

André L. Costa-da-Silva, Osvaldo Marinotti, José M. C. Ribeiro, Maria C. P. Silva, Adriana R. Lopes, Michele S. Barros, Anderson Sá-Nunes, Bianca B. Kojin, Eneas Carvalho, Lincoln Suesdek, Mário Alberto C. Silva-Neto, Anthony A. James, Margareth L. Capurro

Recombinant Antigens Expressed in Pichia pastoris for the Diagnosis of Sleeping Sickness Caused by Trypanosoma brucei gambiense

Stijn Rogé, Liesbeth Van Nieuwenhove, Magali Meul, Annick Heykers, Annette Brouwer de Koning, Nicolas Bebronne, Yves Guisez, Philippe Büscher

Shift in Phenotypic Characteristics of Enterotoxigenic Escherichia coli (ETEC) Isolated from Diarrheal Patients in Bangladesh

Yasmin Ara Begum, Nabilah Ibnat Baby, Abu S. G. Faruque, Nusrat Jahan, Alejandro Cravioto, Ann-Mari Svennerholm, Firdausi Qadri

Filarial Excretory-Secretory Products Induce Human Monocytes to Produce Lymphangiogenic Mediators

Tiffany Weinkopff, Charles Mackenzie, Rob Eversole, Patrick J. Lammie

Evidence of Dengue Virus Transmission and Factors Associated with the Presence of Anti-Dengue Virus Antibodies in Humans in Three Major Towns in Cameroon

Maurice Demanou, Régis Pouillot, Marc Grandadam, Pascal Boisier, Basile Kamgang, Jean Pierre Hervé, Christophe Rogier, Dominique Rousset, Christophe Paupy

Good Quality of Life in Former Buruli Ulcer Patients with Small Lesions: Long-Term Follow-up of the BURULICO Trial

Sandor Klis, Adelita Ranchor, Richard O. Phillips, Kabiru M. Abass, Wilson Tuah, Susanne Loth, Kristien Velding, Tjip S. van der Werf, Ymkje Stienstra

Wolbachia Enhances West Nile Virus (WNV) Infection in the Mosquito Culex tarsalis

Brittany L. Dodson, Grant L. Hughes, Oluwatobi Paul, Amy C. Matacchiero, Laura D. Kramer, Jason L. Rasgon

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

Thomas R. Shelite, Tais B. Saito, Nicole L. Mendell, Bin Gong, Guang Xu, Lynn Soong, Gustavo Valbuena, Donald H. Bouyer, David H. Walker

Experimental Infection of the Pig with Mycobacterium ulcerans: A Novel Model for Studying the Pathogenesis of Buruli Ulcer Disease

Miriam Bolz, Nicolas Ruggli, Marie-Thérèse Ruf, Meret E. Ricklin, Gert Zimmer, Gerd Pluschke

Predictive Tools for Severe Dengue Conforming to World Health Organization 2009 Criteria

Luis R. Carrasco, Yee Sin Leo, Alex R. Cook, Vernon J. Lee, Tun L. Thein, Chi Jong Go, David C. Lye

Effect of Deworming on Physical Fitness of School-Aged Children in Yunnan, China: A Double-Blind, Randomized, Placebo-Controlled Trial

Peiling Yap, Fang-Wei Wu, Zun-Wei Du, Jan Hattendorf, Ran Chen, Jin-Yong Jiang, Susi Kriemler, Stefanie J. Krauth, Xiao-Nong Zhou, Jürg Utzinger, Peter Steinmann

Development of Fatal Intestinal Inflammation in MyD88 Deficient Mice Co-infected with Helminth and Bacterial Enteropathogens

Libo Su, Yujuan Qi, Mei Zhang, Meiqian Weng, Xichen Zhang, Chienwen Su, Hai Ning Shi

Acute Chagas Disease Induces Cerebral Microvasculopathy in Mice

Lindice Mitie Nisimura, Vanessa Estato, Elen Mello de Souza, Patricia A. Reis, Marcos Adriano Lessa, Hugo Caire Castro-Faria-Neto, Mirian Claudia de Souza Pereira, Eduardo Tibiriçá, Luciana Ribeiro Garzoni

Feasibility of a Lateral Flow Test for Neurocysticercosis Using Novel Up-Converting Nanomaterials and a Lightweight Strip Analyzer

Paul L. A. M. Corstjens, Claudia J. de Dood, Jeffrey W. Priest, Hans J. Tanke, Sukwan Handali , and the Cysticercosis Working Group in Peru

Corrections