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Table of Contents: August 2009

COVER

Image Credit:
Issue Image
RNAi-altered gene expression in larval schistosomes.

Confocal fluorescence micrograph of two in vitro-derived primary sporocysts of Schistosoma mansoni showing the somatic distribution of immunoreactive elongation factor 1a (EF1a) protein (green). Larvae are counterstained for actin (red) and DNA (blue) using Alexa-phalloidin and Hoechst dye, respectively. EF1a was one of 32 genes selected for larval phenotypic profiling by RNA interference (see article by de Moraes Mourão, et al. doi:10.1371/journal.pntd.0000502).

Image Credit: M. de Moraes Mourão, N. Dinguirard. Image was captured using a Nikon Eclipse TE2000 epifluorescent microscope equipped with a Bio-Rad Radiance 2100 MP Rainbow confocal imaging system (Keck Laboratory for Biological Imaging, University of Wisconsin).

Editorial

Viewpoints

Assessing the Impact of a Missed Mass Drug Administration in Haiti

Kimberly Y. Won, Madsen Beau de Rochars, Dominique Kyelem, Thomas G. Streit, Patrick J. Lammie

Reviews

Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

Solomon Nwaka, Bernadette Ramirez, Reto Brun, Louis Maes, Frank Douglas, Robert Ridley

Research Articles

Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

Sabine Kuettel, Marc Mosimann, Pascal Mäser, Marcel Kaiser, Reto Brun, Leonardo Scapozza, Remo Perozzo

Importance of Coverage and Endemicity on the Return of Infectious Trachoma after a Single Mass Antibiotic Distribution

Takele Lakew, Wondu Alemayehu, Muluken Melese, Elizabeth Yi, Jenafir I. House, Kevin C. Hong, Zhaoxia Zhou, Kathryn J. Ray, Travis C. Porco, Bruce D. Gaynor, Thomas M. Lietman, Jeremy D. Keenan

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

Sandra D. Melman, Michelle L. Steinauer, Charles Cunningham, Laura S. Kubatko, Ibrahim N. Mwangi, Nirvana Barker Wynn, Martin W. Mutuku, Diana M. S. Karanja, Daniel G. Colley, Carla L. Black, William Evan Secor, Gerald M. Mkoji, Eric S. Loker

High-Resolution Sonography: A New Technique to Detect Nerve Damage in Leprosy

Suman Jain, Leo H. Visser, T. L. N. Praveen, P. Narasimha Rao, Thummalakunta Surekha, Ramesh Ellanti, Thummalakunta L. N. Abhishek, Indira Nath

Predicting Neuropathy and Reactions in Leprosy at Diagnosis and Before Incident Events—Results from the INFIR Cohort Study

W. Cairns S. Smith, Peter G. Nicholls, Loretta Das, Pramila Barkataki, Sujai Suneetha, Lavanya Suneetha, Rupendra Jadhav, P. S. S. Sundar Rao, Einar P. Wilder-Smith, Diana N. J. Lockwood, Wim H. van Brakel

Phenotypic Screen of Early-Developing Larvae of the Blood Fluke, Schistosoma mansoni, using RNA Interference

Marina de Moraes Mourão, Nathalie Dinguirard, Glória R. Franco, Timothy P. Yoshino

Dengue 1 Diversity and Microevolution, French Polynesia 2001–2006: Connection with Epidemiology and Clinics

Elodie Descloux, Van-Mai Cao-Lormeau, Claudine Roche, Xavier De Lamballerie

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

Suman K. Vodnala, Marcela Ferella, Hilda Lundén-Miguel, Evans Betha, Nick van Reet, Daniel Ndem Amin, Bo Öberg, Björn Andersson, Krister Kristensson, Hans Wigzell, Martin E. Rottenberg

Burkholderia pseudomallei Is Genetically Diverse in Agricultural Land in Northeast Thailand

Vanaporn Wuthiekanun, Direk Limmathurotsakul, Narisara Chantratita, Edward J. Feil, Nicholas P. J. Day, Sharon J. Peacock