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Table of Contents: March 2013

COVER

Chikungunya virus-like particle vaccine

Image Credit: Stefan W. Metz (Wageningen University, The Netherlands) and Jean-Yves Sgro (University of Wisconsin, Madison, United States)
Issue Image

Chikungunya is an emerging mosquito-borne virus that causes arthritic disease in humans. Metz et al. describe a prototype chikungunya vaccine that is produced in insect cells using the baculovirus expression system. The vaccine consists of virus-like particles, which elicit a potent immune response and provide complete protection upon viral challenge against viremia and disease symptoms in mice. The picture shows a chikungunya virus-like particle visualized by transmission electron microscopy, merged with a chikungunya virion image (created with VMD, based on PDB ID:2XFB). This new effective and scalable vaccine candidate represents a step forward in the prevention of chikungunya virus infections.

Editorial

Viewpoints

Policy Platform

Evaluation of the European Foundation Initiative into African Research in Neglected Tropical Diseases by the African Fellows

Hester G. O'Neill, Themba Mzilahowa, Nilsa de Deus, Sammy M. Njenga, Elia J. Mmbaga, Thomas M. Kariuki

Review

Research Articles

Interruption of Transmission of Onchocerca volvulus in the Southern Chiapas Focus, México

Mario A. Rodríguez-Pérez, Alfredo Domínguez-Vázquez, Thomas R. Unnasch, Hassan K. Hassan, Juan I. Arredondo-Jiménez, María Eugenia Orozco-Algarra, Kristel B. Rodríguez-Morales, Isabel C. Rodríguez-Luna, Francisco Gibert Prado-Velasco

Arginase Activity - A Marker of Disease Status in Patients with Visceral Leishmaniasis in Ethiopia

Tamrat Abebe, Yegnasew Takele, Teklu Weldegebreal, Tom Cloke, Ellen Closs, Camille Corset, Asrat Hailu, Workagegnehu Hailu, Yifru Sisay, Karina Corware, Margaux Corset, Manuel Modolell, Markus Munder, Fabienne Tacchini-Cottier, Ingrid Müller, Pascale Kropf

Novel Insights into the Genetic Diversity of Balantidium and Balantidium-like Cyst-forming Ciliates

Kateřina Pomajbíková, Miroslav Oborník, Aleš Horák, Klára J. Petrželková, J. Norman Grim, Bruno Levecke, Angelique Todd, Martin Mulama, John Kiyang, David Modrý

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

Nicole Scherr, Philipp Gersbach, Jean-Pierre Dangy, Claudio Bomio, Jun Li, Karl-Heinz Altmann, Gerd Pluschke

Antigenicity and Protective Efficacy of a Leishmania Amastigote-specific Protein, Member of the Super-oxygenase Family, against Visceral Leishmaniasis

Vivian T. Martins, Miguel A. Chávez-Fumagalli, Lourena E. Costa, Adriana M. C. C. Martins, Paula S. Lage, Daniela P. Lage, Mariana C. Duarte, Diogo G. Valadares, Rubens D. M. Magalhães, Tatiana G. Ribeiro, Ronaldo A. P. Nagem, Wanderson D. DaRocha, Wiliam C. B. Régis, Manuel Soto, Eduardo A. F. Coelho, Ana Paula Fernandes, Carlos A. P. Tavares

Rapidly Boosted Plasma IL-5 Induced by Treatment of Human Schistosomiasis haematobium Is Dependent on Antigen Dose, IgE and Eosinophils

Shona Wilson, Frances M. Jones, Hassan K. M. Fofana, Aissata Doucouré, Aly Landouré, Gachuhi Kimani, Joseph K. Mwatha, Moussa Sacko, Birgitte J. Vennervald, David W. Dunne

A Wolbachia wMel Transinfection in Aedes albopictus Is Not Detrimental to Host Fitness and Inhibits Chikungunya Virus

Marcus S. C. Blagrove, Camilo Arias-Goeta, Cristina Di Genua, Anna-Bella Failloux, Steven P. Sinkins

S. haematobium as a Common Cause of Genital Morbidity in Girls: A Cross-sectional Study of Children in South Africa

Ingrid Elise Amlie Hegertun, Kristin Marie Sulheim Gundersen, Elisabeth Kleppa, Siphosenkosi Gift Zulu, Svein Gunnar Gundersen, Myra Taylor, Jane D. Kvalsvig, Eyrun Floerecke Kjetland

Systematic Review and Consensus Guidelines for Environmental Sampling of Burkholderia pseudomallei

Direk Limmathurotsakul, David A. B. Dance, Vanaporn Wuthiekanun, Mirjam Kaestli, Mark Mayo, Jeffrey Warner, David M. Wagner, Apichai Tuanyok, Heiman Wertheim, Tan Yoke Cheng, Chiranjay Mukhopadhyay, Savithiri Puthucheary, Nicholas P. J. Day, Ivo Steinmetz, Bart J. Currie, Sharon J. Peacock

Accuracy of Urine Circulating Cathodic Antigen Test for the Diagnosis of Schistosoma mansoni in Preschool-Aged Children before and after Treatment

Jean T. Coulibaly, Yves K. N'Gbesso, Stefanie Knopp, Nicaise A. N'Guessan, Kigbafori D. Silué, Govert J. van Dam, Eliézer K. N'Goran, Jürg Utzinger

Evidence of Habitat Structuring Aedes albopictus Populations in Réunion Island

Hélène Delatte, Céline Toty, Sébastien Boyer, Anthony Bouetard, Fanny Bastien, Didier Fontenille

Activity of Oxantel Pamoate Monotherapy and Combination Chemotherapy against Trichuris muris and Hookworms: Revival of an Old Drug

Jennifer Keiser, Lucienne Tritten, Angelika Silbereisen, Benjamin Speich, Roberto Adelfio, Mireille Vargas

A Cell-surface Phylome for African Trypanosomes

Andrew P. Jackson, Harriet C. Allison, J. David Barry, Mark C. Field, Christiane Hertz-Fowler, Matthew Berriman

Transmission Risks of Schistosomiasis Japonica: Extraction from Back-propagation Artificial Neural Network and Logistic Regression Model

Jun-Fang Xu, Jing Xu, Shi-Zhu Li, Tia-Wu Jia, Xi-Bao Huang, Hua-Ming Zhang, Mei Chen, Guo-Jing Yang, Shu-Jing Gao, Qing-Yun Wang, Xiao-Nong Zhou

Methodology of Clinical Trials Aimed at Assessing Interventions for Cutaneous Leishmaniasis

Piero Olliaro, Michel Vaillant, Byron Arana, Max Grogl, Farrokh Modabber, Alan Magill, Olivier Lapujade, Pierre Buffet, Jorge Alvar

Modulation of Innate Antigen-Presenting Cell Function by Pre-patent Schistosome Infection

Christine E. Ferragine, Colleen D. Walls, Stephen J. Davies

Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study

Clémentine Schilte, Frédérik Staikovsky, Thérèse Couderc, Yoann Madec, Florence Carpentier, Somar Kassab, Matthew L. Albert, Marc Lecuit, Alain Michault

A Role for Eosinophils in the Intestinal Immunity against Infective Ascaris suum Larvae

Dries Masure, Johnny Vlaminck, Tao Wang, Koen Chiers, Wim Van den Broeck, Jozef Vercruysse, Peter Geldhof

Biodiversity Can Help Prevent Malaria Outbreaks in Tropical Forests

Gabriel Zorello Laporta, Paulo Inácio Knegt Lopez de Prado, Roberto André Kraenkel, Renato Mendes Coutinho, Maria Anice Mureb Sallum

Parasitic Zoonoses: One Health Surveillance in Northern Saskatchewan

Janna M. Schurer, Momar Ndao, Stuart Skinner, James Irvine, Stacey A. Elmore, Tasha Epp, Emily J. Jenkins

The Incidence of Human Cysticercosis in a Rural Community of Eastern Zambia

Kabemba E. Mwape, Isaac K. Phiri, Nicolas Praet, Niko Speybroeck, John B. Muma, Pierre Dorny, Sarah Gabriël

Dengue Surveillance in Veterans Affairs Healthcare Facilities, 2007–2010

Patricia L. Schirmer, Cynthia A. Lucero-Obusan, Stephen R. Benoit, Luis M. Santiago, Danielle Stanek, Achintya Dey, Mirsonia Martinez, Gina Oda, Mark Holodniy

Active Surveillance of Hansen's Disease (Leprosy): Importance for Case Finding among Extra-domiciliary Contacts

Maria L. N. Moura, Kathryn M. Dupnik, Gabriel A. A. Sampaio, Priscilla F. C. Nóbrega, Ana K. Jeronimo, Jose M. do Nascimento-Filho, Roberta L. Miranda Dantas, Jose W. Queiroz, James D. Barbosa, Gutemberg Dias, Selma M. B. Jeronimo, Marcia C. F. Souza, Maurício L. Nobre

Twenty Years of DENV-2 Activity in Brazil: Molecular Characterization and Phylogeny of Strains Isolated from 1990 to 2010

Nieli Rodrigues da Costa Faria, Rita Maria Ribeiro Nogueira, Ana Maria Bispo de Filippis, Jaqueline Bastos Santos Simões, Fernanda de Bruycker Nogueira, Monique da Rocha Queiroz Lima, Flavia Barreto dos Santos

Impact of Community-Based Lymphedema Management on Perceived Disability among Patients with Lymphatic Filariasis in Orissa State, India

Philip J. Budge, Kristen M. Little, Katherine E. Mues, Erin D. Kennedy, Aiysha Prakash, Jonathan Rout, LeAnne M. Fox

Microbiological, Histological, Immunological, and Toxin Response to Antibiotic Treatment in the Mouse Model of Mycobacterium ulcerans Disease

Fred Stephen Sarfo, Paul J. Converse, Deepak V. Almeida, Jihui Zhang, Clive Robinson, Mark Wansbrough-Jones, Jacques H. Grosset

Prevalence and Risk Factors Associated with Human Taenia Solium Infections in Mbozi District, Mbeya Region, Tanzania

Gloria Mwanjali, Charles Kihamia, Deodatus Vitalis Conatus Kakoko, Faustin Lekule, Helena Ngowi, Maria Vang Johansen, Stig Milan Thamsborg, Arve Lee Willingham III

Antimicrobial Resistance in Invasive Non-typhoid Salmonella from the Democratic Republic of the Congo: Emergence of Decreased Fluoroquinolone Susceptibility and Extended-spectrum Beta Lactamases

Octavie Lunguya, Veerle Lejon, Marie-France Phoba, Sophie Bertrand, Raymond Vanhoof, Youri Glupczynski, Jan Verhaegen, Jean-Jacques Muyembe-Tamfum, Jan Jacobs

Host Cell Transcriptome Profile during Wild-Type and Attenuated Dengue Virus Infection

October M. Sessions, Ying Tan, Kenneth C. Goh, Yujing Liu, Patrick Tan, Steve Rozen, Eng Eong Ooi

Spatiotemporal Transmission and Determinants of Typhoid and Paratyphoid Fever in Hongta District, Yunnan Province, China

Jin-Feng Wang, Yan Wang, Jing Zhang, George Christakos, Jun-Ling Sun, Xin Liu, Lin Lu, Xiao-Qing Fu, Yu-Qiong Shi, Xue-Mei Li

Serovar Diversity of Pathogenic Leptospira Circulating in the French West Indies

Pascale Bourhy, Cécile Herrmann Storck, Rafaelle Theodose, Claude Olive, Muriel Nicolas, Patrick Hochedez, Isabelle Lamaury, Farida Zinini, Sylvie Brémont, Annie Landier, Sylvie Cassadou, Jacques Rosine, Mathieu Picardeau

Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring

Tamsyn Derrick, Chrissy h. Roberts, Megha Rajasekhar, Sarah E. Burr, Hassan Joof, Pateh Makalo, Robin L. Bailey, David C. W. Mabey, Matthew J. Burton, Martin J. Holland

Assessing the Effect of an Integrated Control Strategy for Schistosomiasis Japonica Emphasizing Bovines in a Marshland Area of Hubei Province, China: A Cluster Randomized Trial

Xi-Cheng Hong, Xing-Jian Xu, Xi Chen, Yue-Sheng Li, Chuan-Hua Yu, Yi Yuan, Yan-Yan Chen, Ren-Dong Li, Juan Qiu, Zong-Chuan Liu, Ping Yi, Guang-Hui Ren, Hong-Bin He

Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

Stefan W. Metz, Joy Gardner, Corinne Geertsema, Thuy T. Le, Lucas Goh, Just M. Vlak, Andreas Suhrbier, Gorben P. Pijlman

Podoconiosis and Soil-Transmitted Helminths (STHs): Double Burden of Neglected Tropical Diseases in Wolaita Zone, Rural Southern Ethiopia

Bineyam Taye, Bereket Alemayehu, Asaye Birhanu, Kassu Desta, Sisay Addisu, Beyene Petros, Gail Davey, Aster Tsegaye

Investigating the Role for IL-21 in Rabies Virus Vaccine-induced Immunity

Corin L. Dorfmeier, Evgeni P. Tzvetkov, Anthony Gatt, James P. McGettigan

Characterization of Phlebotomus papatasi Peritrophins, and the Role of PpPer1 in Leishmania major Survival in its Natural Vector

Iliano V. Coutinho-Abreu, Narinder K. Sharma, Maricela Robles-Murguia, Marcelo Ramalho-Ortigao

The Sequential Aerosol Technique: A Major Component in an Integrated Strategy of Intervention against Riverine Tsetse in Ghana

Yahaya Adam, Giuliano Cecchi, Patrick M. Kgori, Tanguy Marcotty, Charles I. Mahama, Martin Abavana, Benita Anderson, Massimo Paone, Raffaele Mattioli, Jérémy Bouyer

Vectorial Capacity of Aedes aegypti for Dengue Virus Type 2 Is Reduced with Co-infection of Metarhizium anisopliae

Javier A. Garza-Hernández, Mario A. Rodríguez-Pérez, Ma Isabel Salazar, Tanya L. Russell, Monsuru A. Adeleke, Erik de J. de Luna-Santillana, Filiberto Reyes-Villanueva

Drivers of Echinococcus multilocularis Transmission in China: Small Mammal Diversity, Landscape or Climate?

Patrick Giraudoux, Francis Raoul, David Pleydell, Tiaoying Li, Xiuming Han, Jiamin Qiu, Yan Xie, Hu Wang, Akira Ito, Philip S. Craig

Rapid and Scalable Plant-based Production of a Cholera Toxin B Subunit Variant to Aid in Mass Vaccination against Cholera Outbreaks

Krystal Teasley Hamorsky, J. Calvin Kouokam, Lauren J. Bennett, Keegan J. Baldauf, Hiroyuki Kajiura, Kazuhito Fujiyama, Nobuyuki Matoba

Predictive vs. Empiric Assessment of Schistosomiasis: Implications for Treatment Projections in Ghana

Achille Kabore, Nana-Kwadwo Biritwum, Philip W. Downs, Ricardo J. Soares Magalhaes, Yaobi Zhang, Eric A. Ottesen

Diagnosis and Treatment of Leprosy Reactions in Integrated Services - The Patients' Perspective in Nepal

Sonia F. Raffe, Min Thapa, Saraswoti Khadge, Krishna Tamang, Deanna Hagge, Diana N. J. Lockwood

Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis

Lucja A. Labuda, Ulysse Ateba-Ngoa, Eliane Ngoune Feugap, Jorn J. Heeringa, Luciën E. P. M. van der Vlugt, Regina B. A. Pires, Ludovic Mewono, Peter G. Kremsner, Menno C. van Zelm, Ayola A. Adegnika, Maria Yazdanbakhsh, Hermelijn H. Smits

Neurocysticercosis: HP10 Antigen Detection Is Useful for the Follow-up of the Severe Patients

Agnès Fleury, Esperanza Garcia, Marisela Hernández, Roger Carrillo, Tzipe Govezensky, Gladis Fragoso, Edda Sciutto, Leslie J. S. Harrison, R. Michael Evans Parkhouse

Isolation of Irkut Virus from a Murina leucogaster Bat in China

Ye Liu, Shoufeng Zhang, Jinghui Zhao, Fei Zhang, Rongliang Hu

Evaluation of the Health-related Quality of Life of Children in Schistosoma haematobium-endemic Communities in Kenya: A Cross-sectional Study

Carolyn C. Terer, Amaya L. Bustinduy, Ruth V. Magtanong, Ng'ethe Muhoho, Peter L. Mungai, Eric M. Muchiri, Uriel Kitron, Charles H. King, Francis M. Mutuku

Molecular Detection and Characterization of Tick-borne Pathogens in Dogs and Ticks from Nigeria

Joshua Kamani, Gad Baneth, Kosta Y. Mumcuoglu, Ndadilnasiya E. Waziri, Osnat Eyal, Yifat Guthmann, Shimon Harrus

Prevalence of Trypanosoma cruzi Infection among People Aged 15 to 89 Years Inhabiting the Department of Casanare (Colombia)

Fredy Roberto Salazar Gutierrez, Martha Liliana Trujillo Güiza, Magally del Carmen Escobar Martínez