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Table of Contents: August 2013

COVER

Nippostrongylus brasiliensis

Image Credit: J. Claire Hoving
Issue Image

A gravid adult female Nippostrongylus brasiliensis worm was collected from the small intestine of an infected BALB/c mouse and photographed with a Nikon light microscope and mounted digital camera. The picture shows a hooked anterior end containing eggs. See Nieuwenhuizen et al.

Editorial

Viewpoints

Challenges in the Interpretation of Dengue Vaccine Trial Results

Isabel Rodriguez-Barraquer, Luis Mier-y-Teran-Romero, Donald S. Burke, Derek A. T. Cummings

Toward the Global Control of Human Scabies: Introducing the International Alliance for the Control of Scabies

Daniel Engelman, Karen Kiang, Olivier Chosidow, James McCarthy, Claire Fuller, Patrick Lammie, Roderick Hay, Andrew Steer, on behalf of the members of the International Alliance for the Control of Scabies (IACS)

Policy Platform

Addressing Ethical, Social, and Cultural Issues in Global Health Research

James V. Lavery, Shane K. Green, Sunita V. S. Bandewar, Anant Bhan, Abdallah Daar, Claudia I. Emerson, Hassan Masum, Filippo M. Randazzo, Jerome A. Singh, Ross E. G. Upshur, Peter A. Singer

Symposiums

Concurrent Infection with Murine Typhus and Scrub Typhus in Southern Laos—the Mixed and the Unmixed

Koukeo Phommasone, Daniel H. Paris, Tippawan Anantatat, Josée Castonguay-Vanier, Sommay Keomany, Phoutthalavanh Souvannasing, Stuart D. Blacksell, Mayfong Mayxay, Paul N. Newton

Fatal Dengue in Patients with Sickle Cell Disease or Sickle Cell Anemia in Curaçao: Two Case Reports

Fleur M. Moesker, Fred D. Muskiet, Jeanne J. Koeijers, Pieter L. A. Fraaij, Isaac Gerstenbluth, Eric C. M. van Gorp, Albert D. M. E. Osterhaus

Research Articles

Synthesising 30 Years of Mathematical Modelling of Echinococcus Transmission

Jo-An M. Atkinson, Gail M. Williams, Laith Yakob, Archie C. A. Clements, Tamsin S. Barnes, Donald P. McManus, Yu Rong Yang, Darren J. Gray

A Cross-Reactive Monoclonal Antibody to Nematode Haemoglobin Enhances Protective Immune Responses to Nippostrongylus brasiliensis

Natalie E. Nieuwenhuizen, Jeanne M. Meter, William G. Horsnell, J. Claire Hoving, Lizette Fick, Michael F. Sharp, Matthew G. Darby, Suraj P. Parihar, Frank Brombacher, Andreas L. Lopata

Adhesins of Leptospira interrogans Mediate the Interaction to Fibrinogen and Inhibit Fibrin Clot Formation In Vitro

Rosane Oliveira, Renan F. Domingos, Gabriela H. Siqueira, Luis G. Fernandes, Natalie M. Souza, Monica L. Vieira, Zenaide M. de Morais, Silvio A. Vasconcellos, Ana L. T. O. Nascimento

Differences in Primary Sites of Infection between Zoonotic and Human Tuberculosis: Results from a Worldwide Systematic Review

Salome Dürr, Borna Müller, Silvia Alonso, Jan Hattendorf, Cláudio J. M. Laisse, Paul D. van Helden, Jakob Zinsstag

Phylogeography of Japanese Encephalitis Virus: Genotype Is Associated with Climate

Amy J. Schuh, Melissa J. Ward, Andrew J. Leigh Brown, Alan D. T. Barrett

A Randomized Trial of Two Coverage Targets for Mass Treatment with Azithromycin for Trachoma

Sheila K. West, Robin Bailey, Beatriz Munoz, Tansy Edwards, Harran Mkocha, Charlotte Gaydos, Thomas Lietman, Travis Porco, David Mabey, Thomas C. Quinn

Evolutionary History and Phylogeography of Rabies Viruses Associated with Outbreaks in Trinidad

Janine F. R. Seetahal, Andres Velasco-Villa, Orchid M. Allicock, Abiodun A. Adesiyun, Joseph Bissessar, Kirk Amour, Annmarie Phillip-Hosein, Denise A. Marston, Lorraine M. McElhinney, Mang Shi, Cheryl-Ann Wharwood, Anthony R. Fooks, Christine V. F. Carrington

Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay

Helton J. Wiggers, Josmar R. Rocha, William B. Fernandes, Renata Sesti-Costa, Zumira A. Carneiro, Juliana Cheleski, Albérico B. F. da Silva, Luiz Juliano, Maria H. S. Cezari, João S. Silva, James H. McKerrow, Carlos A. Montanari

Development of a Fluorescent Based Immunosensor for the Serodiagnosis of Canine Leishmaniasis Combining Immunomagnetic Separation and Flow Cytometry

Susana Sousa, Luís Cardoso, Steven G. Reed, Alexandre B. Reis, Olindo A. Martins-Filho, Ricardo Silvestre, Anabela Cordeiro da Silva

Designing Programs for Eliminating Canine Rabies from Islands: Bali, Indonesia as a Case Study

Sunny E. Townsend, I Putu Sumantra, Pudjiatmoko, Gusti Ngurah Bagus, Eric Brum, Sarah Cleaveland, Sally Crafter, Ayu P. M. Dewi, Dewa Made Ngurah Dharma, Jonathan Dushoff, Janice Girardi, I Ketut Gunata, Elly F. Hiby, Corlevin Kalalo, Darryn L. Knobel, I Wayan Mardiana, Anak Agung Gde Putra, Luuk Schoonman, Helen Scott–Orr, Mike Shand, I Wayan Sukanadi, Pebi Purwo Suseno, Daniel T. Haydon, Katie Hampson

The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta

Christian Castillo, Galia Ramírez, Carolina Valck, Lorena Aguilar, Ismael Maldonado, Carlos Rosas, Norbel Galanti, Ulrike Kemmerling, Arturo Ferreira

Prevalence and Associated Factors of Schistosomiasis among Children in Yemen: Implications for an Effective Control Programme

Hany Sady, Hesham M. Al-Mekhlafi, Mohammed A. K. Mahdy, Yvonne A. L. Lim, Rohela Mahmud, Johari Surin

Evaluation of the Diagnostic Utility of the Traditional and Revised WHO Dengue Case Definitions

Gamaliel Gutiérrez, Lionel Gresh, María Ángeles Pérez, Douglas Elizondo, William Avilés, Guillermina Kuan, Ángel Balmaseda, Eva Harris

The Pivotal Role of 5-Lipoxygenase-Derived LTB4 in Controlling Pulmonary Paracoccidioidomycosis

Patrícia Campi Santos, Daniel Assis Santos, Lucas Secchim Ribeiro, Caio Tavares Fagundes, Talles Prosperi de Paula, Thiago Vinícius Avila, Ludmila de Matos Baltazar, Mila Moreira Madeira, Rosana de Carvalho Cruz, Ana Carolina Fialho Dias, Fabiana Simão Machado, Mauro Martins Teixeira, Patrícia Silva Cisalpino, Danielle G. Souza

Differential Epidemiology of Salmonella Typhi and Paratyphi A in Kathmandu, Nepal: A Matched Case Control Investigation in a Highly Endemic Enteric Fever Setting

Abhilasha Karkey, Corinne N. Thompson, Nga Tran Vu Thieu, Sabina Dongol, Tu Le Thi Phuong, Phat Voong Vinh, Amit Arjyal, Laura B. Martin, Simona Rondini, Jeremy J. Farrar, Christiane Dolecek, Buddha Basnyat, Stephen Baker

The Outcome of Trachomatous Trichiasis Surgery in Ethiopia: Risk Factors for Recurrence

Saul N. Rajak, Esmael Habtamu, Helen A. Weiss, Amir B. Kello, Bayeh Abera, Mulat Zerihun, Teshome Gebre, Clare E. Gilbert, Peng T. Khaw, Paul M. Emerson, Matthew J. Burton

Venom of the Brazilian Spider Sicarius ornatus (Araneae, Sicariidae) Contains Active Sphingomyelinase D: Potential for Toxicity after Envenomation

Priscila Hess Lopes, Rogério Bertani, Rute M. Gonçalves-de-Andrade, Roberto H. Nagahama, Carmen W. van den Berg, Denise V. Tambourgi

Identification of MicroRNA-Like RNAs in Mycelial and Yeast Phases of the Thermal Dimorphic Fungus Penicillium marneffei

Susanna K. P. Lau, Wang-Ngai Chow, Annette Y. P. Wong, Julian M. Y. Yeung, Jessie Bao, Na Zhang, Si Lok, Patrick C. Y. Woo, Kwok-Yung Yuen

Mycetoma Herbal Treatment: The Mycetoma Research Centre, Sudan Experience

Eshraga A. Ezaldeen, Ahmed Hassan Fahal, Anjom Osman

Molecular Assays for Determining Mycobacterium leprae Viability in Tissues of Experimentally Infected Mice

Grace L. Davis, Nashone A. Ray, Ramanuj Lahiri, Thomas P. Gillis, James L. Krahenbuhl, Diana L. Williams, Linda B. Adams

The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

Marwa K. Ibrahim, Jeffrey L. Barnes, Gregory M. Anstead, Fabio Jimenez, Bruno L. Travi, Alex G. Peniche, E. Yaneth Osorio, Seema S. Ahuja, Peter C. Melby

Multi-Gene Detection and Identification of Mosquito-Borne RNA Viruses Using an Oligonucleotide Microarray

Nathan D. Grubaugh, Scott S. McMenamy, Michael J. Turell, John S. Lee

Use of a Cholera Rapid Diagnostic Test during a Mass Vaccination Campaign in Response to an Epidemic in Guinea, 2012

Isabel Martinez-Pino, Francisco J. Luquero, Kéïta Sakoba, Souleymane Sylla, Melatwork Haile, Rebecca F. Grais, Iza Ciglenecki, Marie-Laure Quilici, Anne-Laure Page

Benznidazole and Posaconazole in Experimental Chagas Disease: Positive Interaction in Concomitant and Sequential Treatments

Lívia de Figueiredo Diniz, Julio A. Urbina, Isabel Mayer de Andrade, Ana Lia Mazzeti, Tassiane Assíria F. Martins, Ivo Santana Caldas, André Talvani, Isabela Ribeiro, Maria Terezinha Bahia

Cholera in Pregnancy: Outcomes from a Specialized Cholera Treatment Unit for Pregnant Women in Léogâne, Haiti

Iza Ciglenecki, Mathieu Bichet, Javier Tena, Erneau Mondesir, Mathieu Bastard, Nguyen-Toan Tran, Annick Antierens, Nelly Staderini

Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue Infection

Liang Cui, Yie Hou Lee, Yadunanda Kumar, Fengguo Xu, Kun Lu, Eng Eong Ooi, Steven R. Tannenbaum, Choon Nam Ong

Evaluating Paratransgenesis as a Potential Control Strategy for African Trypanosomiasis

Jan Medlock, Katherine E. Atkins, David N. Thomas, Serap Aksoy, Alison P. Galvani

Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells

Laura E. Layland, Kathrin Straubinger, Manuel Ritter, Eva Loffredo-Verde, Holger Garn, Tim Sparwasser, Clarissa Prazeres da Costa

Helminthic Infections Rates and Malaria in HIV-Infected Pregnant Women on Anti-Retroviral Therapy in Rwanda

Emil Ivan, Nigel J. Crowther, Eugene Mutimura, Lawrence Obado Osuwat, Saskia Janssen, Martin P. Grobusch

Metabonomics Reveals Drastic Changes in Anti-Inflammatory/Pro-Resolving Polyunsaturated Fatty Acids-Derived Lipid Mediators in Leprosy Disease

Julio J. Amaral, Luis Caetano M. Antunes, Cristiana S. de Macedo, Katherine A. Mattos, Jun Han, Jingxi Pan, André L. P. Candéa, Maria das Graças M. O. Henriques, Marcelo Ribeiro-Alves, Christoph H. Borchers, Euzenir N. Sarno, Patrícia T. Bozza, B. Brett Finlay, Maria Cristina V. Pessolani

Imported Amoebic Liver Abscess in France

Hugues Cordel, Virginie Prendki, Yoann Madec, Sandrine Houze, Luc Paris, Patrice Bourée, Eric Caumes, Sophie Matheron, Olivier Bouchaud , the ALA Study Group

The Effect of Vaccination Coverage and Climate on Japanese Encephalitis in Sarawak, Malaysia

Daniel E. Impoinvil, Mong How Ooi, Peter J. Diggle, Cyril Caminade, Mary Jane Cardosa, Andrew P. Morse, Matthew Baylis, Tom Solomon

Molecular Surveillance of Dengue in Semarang, Indonesia Revealed the Circulation of an Old Genotype of Dengue Virus Serotype-1

Sukmal Fahri, Benediktus Yohan, Hidayat Trimarsanto, S. Sayono, Suharyo Hadisaputro, Edi Dharmana, Din Syafruddin, R. Tedjo Sasmono

Culling Dogs in Scenarios of Imperfect Control: Realistic Impact on the Prevalence of Canine Visceral Leishmaniasis

Danielle N. C. C. Costa, Cláudia T. Codeço, Moacyr A. Silva, Guilherme L. Werneck

Symptomatic Versus Inapparent Outcome in Repeat Dengue Virus Infections Is Influenced by the Time Interval between Infections and Study Year

Magelda Montoya, Lionel Gresh, Juan Carlos Mercado, Katherine L. Williams, Maria José Vargas, Gamaliel Gutierrez, Guillermina Kuan, Aubree Gordon, Angel Balmaseda, Eva Harris

The Geographical Distribution and Burden of Trachoma in Africa

Jennifer L. Smith, Rebecca M. Flueckiger, Pamela J. Hooper, Sarah Polack, Elizabeth A. Cromwell, Stephanie L. Palmer, Paul M. Emerson, David C. W. Mabey, Anthony W. Solomon, Danny Haddad, Simon J. Brooker

An Epidemic of Dengue-1 in a Remote Village in Rural Laos

Audrey Dubot-Pérès, Phengta Vongphrachanh, Justin Denny, Rattanaphone Phetsouvanh, Singharath Linthavong, Bounthanom Sengkeopraseuth, Amphai Khasing, Vimattha Xaythideth, Catrin E. Moore, Manivanh Vongsouvath, Josée Castonguay-Vanier, Bountoy Sibounheuang, Thaksinaporn Taojaikong, Anisone Chanthongthip, Xavier de Lamballerie, Paul N. Newton

Tracing the Tiger: Population Genetics Provides Valuable Insights into the Aedes (Stegomyia) albopictus Invasion of the Australasian Region

Nigel W. Beebe, Luke Ambrose, Lydia A. Hill, Joseph B. Davis, George Hapgood, Robert D. Cooper, Richard C. Russell, Scott A. Ritchie, Lisa J. Reimer, Neil F. Lobo, Din Syafruddin, Andrew F. van den Hurk

Wolbachia-Associated Bacterial Protection in the Mosquito Aedes aegypti

Yixin H. Ye, Megan Woolfit, Edwige Rancès, Scott L. O'Neill, Elizabeth A. McGraw

Induction of Mouse Melioidosis with Meningitis by CD11b+ Phagocytic Cells Harboring Intracellular B. pseudomallei as a Trojan Horse

Pei-Ju Liu, Yao-Shen Chen, Hsi-Hsu Lin, Wei-Feng Ni, Tsung-Han Hsieh, Hsu-Tzu Chen, Ya-Lei Chen

Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease

Monisha Dhiman, Yun A. Coronado, Cecilia K. Vallejo, John R. Petersen, Adetoun Ejilemele, Sonia Nuñez, Maria Paola Zago, Heidi Spratt, Nisha Jain Garg

Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic Pathway

Mariana S. Cardoso, Caroline Junqueira, Ricardo C. Trigueiro, Hosam Shams-Eldin, Cristiana S. Macedo, Patrícia R. Araújo, Dawidson A. Gomes, Patrícia M. Martinelli, Jürgen Kimmel, Philipp Stahl, Sebastian Niehus, Ralph T. Schwarz, José O. Previato, Lucia Mendonça-Previato, Ricardo T. Gazzinelli, Santuza M. R. Teixeira

Soil-Transmitted Helminth Infections and Nutritional Status in School-age Children from Rural Communities in Honduras

Ana Lourdes Sanchez, Jose Antonio Gabrie, Mary-Theresa Usuanlele, Maria Mercedes Rueda, Maritza Canales, Theresa W. Gyorkos

TNF-α and CD8+ T Cells Mediate the Beneficial Effects of Nitric Oxide Synthase-2 Deficiency in Pulmonary Paracoccidioidomycosis

Simone Bernardino, Adriana Pina, Maíra Felonato, Tânia A. Costa, Eliseu Frank de Araújo, Cláudia Feriotti, Silvia Boschi Bazan, Alexandre C. Keller, Katia R. M. Leite, Vera L. G. Calich

Identification of Immunogenic Salmonella enterica Serotype Typhi Antigens Expressed in Chronic Biliary Carriers of S. Typhi in Kathmandu, Nepal

Richelle C. Charles, Tania Sultana, Mohammad Murshid Alam, Yanan Yu, Ying Wu-Freeman, Meagan Kelly Bufano, Sean M. Rollins, Lillian Tsai, Jason B. Harris, Regina C. LaRocque, Daniel T. Leung, W. Abdullah Brooks, Tran Vu Thieu Nga, Sabina Dongol, Buddha Basnyat, Stephen B. Calderwood, Jeremy Farrar, Farhana Khanam, John S. Gunn, Firdausi Qadri, Stephen Baker, Edward T. Ryan

Mini-FLOTAC, an Innovative Direct Diagnostic Technique for Intestinal Parasitic Infections: Experience from the Field

Beatrice Divina Barda, Laura Rinaldi, Davide Ianniello, Henry Zepherine, Fulvio Salvo, Tsetan Sadutshang, Giuseppe Cringoli, Massimo Clementi, Marco Albonico

Potential Cost-Effectiveness of Schistosomiasis Treatment for Reducing HIV Transmission in Africa – The Case of Zimbabwean Women

Martial L. Ndeffo Mbah, Eric M. Poolman, Katherine E. Atkins, Evan W. Orenstein, Lauren Ancel Meyers, Jeffrey P. Townsend, Alison P. Galvani

Aedes (Stegomyia) albopictus (Skuse): A Potential Vector of Zika Virus in Singapore

Pei-Sze Jeslyn Wong, Mei-zhi Irene Li, Chee-Seng Chong, Lee-Ching Ng, Cheong-Huat Tan

Health Access Livelihood Framework Reveals Potential Barriers in the Control of Schistosomiasis in the Dongting Lake Area of Hunan Province, China

Julie Balen, Zhao-Chun Liu, Donald P. McManus, Giovanna Raso, Jürg Utzinger, Shui-Yuan Xiao, Dong-Bao Yu, Zheng-Yuan Zhao, Yue-Sheng Li

Epidemiology of and Impact of Insecticide Spraying on Chagas Disease in Communities in the Bolivian Chaco

Aaron M. Samuels, Eva H. Clark, Gerson Galdos-Cardenas, Ryan E. Wiegand, Lisbeth Ferrufino, Silvio Menacho, Jose Gil, Jennifer Spicer, Julia Budde, Michael Z. Levy, Ricardo W. Bozo, Robert H. Gilman, Caryn Bern , the Working Group on Chagas Disease in Bolivia and Peru