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Table of Contents: October 2013

COVER

Neurotoxicity in snakebite.

Image Credit: Sarith Ranawaka
Issue Image

Snakebite is a global health problem, and neurotoxicity is a major cause of death, after snake envenoming. There are many unanswered questions regarding neurotoxicity. More research is needed to understand its complex pathophysiological mechanisms and identify new treatments, and global efforts are needed to make currently available treatments more accessible in the resource-limited settings where snakebite is common. See Ranawaka et al.

Editorial

An Unfolding Tragedy of Chagas Disease in North America

Peter J. Hotez, Eric Dumonteil, Miguel Betancourt Cravioto, Maria Elena Bottazzi, Roberto Tapia-Conyer, Sheba Meymandi, Unni Karunakara, Isabela Ribeiro, Rachel M. Cohen, Bernard Pecoul

Viewpoints

Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis

Ricardo J. Soares Magalhães, Cláudia Fançony, Dina Gamboa, António J. Langa, José Carlos Sousa-Figueiredo, Archie C. A. Clements, Susana Vaz Nery

Historical Profiles and Perspectives

Ten Years of Podoconiosis Research in Ethiopia

Kebede Deribe, Sara Tomczyk, Fasil Tekola-Ayele

Symposium

Pulmonary Aspergilloma: A Treatment Challenge in Sub-Saharan Africa

Christian Pohl, Levan Jugheli, Fredrick Haraka, Elirehema Mfinanga, Khadija Said, Klaus Reither

Reviews

Neurotoxicity in Snakebite—The Limits of Our Knowledge

Udaya K. Ranawaka, David G. Lalloo, H. Janaka de Silva

Research Articles

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

Deu John M. Cruz, Rafaela M. Bonotto, Rafael G. B. Gomes, Camila T. da Silva, Juliana B. Taniguchi, Joo Hwan No, Benoit Lombardot, Olivier Schwartz, Michael A. E. Hansen, Lucio H. Freitas-Junior

Epilepsy and Neurocysticercosis in Latin America: A Systematic Review and Meta-analysis

Elisa Bruno, Alessandro Bartoloni, Lorenzo Zammarchi, Marianne Strohmeyer, Filippo Bartalesi, Javier A. Bustos, Saul Santivañez, Héctor H. García, Alessandra Nicoletti , the COHEMI Project Study Group

Population Structure and Evidence for Both Clonality and Recombination among Brazilian Strains of the Subgenus Leishmania (Viannia)

Katrin Kuhls, Elisa Cupolillo, Soraia O. Silva, Carola Schweynoch, Mariana Côrtes Boité, Maria N. Mello, Isabel Mauricio, Michael Miles, Thierry Wirth, Gabriele Schönian

Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1)

Alicia Arnott, Ivo Mueller, Paul A. Ramsland, Peter M. Siba, John C. Reeder, Alyssa E. Barry

Mosquito Vector Diversity across Habitats in Central Thailand Endemic for Dengue and Other Arthropod-Borne Diseases

Panpim Thongsripong, Amy Green, Pattamaporn Kittayapong, Durrell Kapan, Bruce Wilcox, Shannon Bennett

Long-Lasting Insecticidal Nets Are Synergistic with Mass Drug Administration for Interruption of Lymphatic Filariasis Transmission in Nigeria

Abel Eigege, Alphonsus Kal, Emmanuel Miri, Adamu Sallau, John Umaru, Hayward Mafuyai, Yohanna S. Chuwang, Goshit Danjuma, Jacob Danboyi, Solomon E. Adelamo, Bulus S. Mancha, Bridget Okoeguale, Amy E. Patterson, Lindsay Rakers, Frank O. Richards

Development of Genetic System to Inactivate a Borrelia turicatae Surface Protein Selectively Produced within the Salivary Glands of the Arthropod Vector

Job E. Lopez, Hannah K. Wilder, Reid Hargrove, Christopher P. Brooks, Karin E. Peterson, Paul A. Beare, Daniel E. Sturdevant, Vijayaraj Nagarajan, Sandra J. Raffel, Tom G. Schwan

Burden of Giardia duodenalis Infection and Its Adverse Effects on Growth of Schoolchildren in Rural Malaysia

Hesham M. Al-Mekhlafi, Mohamed T. Al-Maktari, Rohana Jani, Abdulhamid Ahmed, Tengku Shahrul Anuar, Norhayati Moktar, Mohammed A. K. Mahdy, Yvonne A. L. Lim, Rohela Mahmud, Johari Surin

P-I Snake Venom Metalloproteinase Is Able to Activate the Complement System by Direct Cleavage of Central Components of the Cascade

Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C. V. Portaro, Solange M. T. Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W. van den Berg, Denise V. Tambourgi

Microsatellite DNA Analysis Revealed a Drastic Genetic Change of Plasmodium vivax Population in the Republic of Korea During 2002 and 2003

Moritoshi Iwagami, Seung-Young Hwang, So-Hee Kim, So-Jung Park, Ga-Young Lee, Emilie Louise Akiko Matsumoto-Takahashi, Weon-Gyu Kho, Shigeyuki Kano

Gatifloxacin Versus Ofloxacin for the Treatment of Uncomplicated Enteric Fever in Nepal: An Open-Label, Randomized, Controlled Trial

Samir Koirala, Buddha Basnyat, Amit Arjyal, Olita Shilpakar, Kabina Shrestha, Rishav Shrestha, Upendra Man Shrestha, Krishna Agrawal, Kanika Deshpande Koirala, Sudeep Dhoj Thapa, Abhilasha Karkey, Sabina Dongol, Abhishek Giri, Mila Shakya, Kamal Raj Pathak, James Campbell, Stephen Baker, Jeremy Farrar, Marcel Wolbers, Christiane Dolecek

Identification of Strain-Specific B-cell Epitopes in Trypanosoma cruzi Using Genome-Scale Epitope Prediction and High-Throughput Immunoscreening with Peptide Arrays

Tiago Antônio de Oliveira Mendes, João Luís Reis Cunha, Rodrigo de Almeida Lourdes, Gabriela Flávia Rodrigues Luiz, Lucas Dhom Lemos, Ana Rita Rocha dos Santos, Antônia Cláudia Jácome da Câmara, Lúcia Maria da Cunha Galvão, Caryn Bern, Robert H. Gilman, Ricardo Toshio Fujiwara, Ricardo Tostes Gazzinelli, Daniella Castanheira Bartholomeu

On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni

Leonardo P. Farias, Greice Krautz-Peterson, Cibele A. Tararam, Bogar O. Araujo-Montoya, Tatiana R. Fraga, Henrique K. Rofatto, Floriano P. Silva-Jr, Lourdes Isaac, Akram A. Da'dara, R. Alan Wilson, Charles B. Shoemaker, Luciana C. C. Leite

Evidence for Endemic Chikungunya Virus Infections in Bandung, Indonesia

Herman Kosasih, Quirijn de Mast, Susana Widjaja, Primal Sudjana, Ungke Antonjaya, Chairin Ma'roef, Silvita Fitri Riswari, Kevin R. Porter, Timothy H. Burgess, Bachti Alisjahbana, Andre van der Ven, Maya Williams

Infection with Usutu Virus Induces an Autophagic Response in Mammalian Cells

Ana-Belén Blázquez, Estela Escribano-Romero, Teresa Merino-Ramos, Juan-Carlos Saiz, Miguel A. Martín-Acebes

Diversity and Epidemiology of Mokola Virus

Joe Kgaladi, Nicolette Wright, Jessica Coertse, Wanda Markotter, Denise Marston, Anthony R. Fooks, Conrad M. Freuling, Thomas F. Müller, Claude T. Sabeta, Louis H. Nel

In Pulmonary Paracoccidioidomycosis IL-10 Deficiency Leads to Increased Immunity and Regressive Infection without Enhancing Tissue Pathology

Tânia A. Costa, Silvia B. Bazan, Claudia Feriotti, Eliseu F. Araújo, Ênio J. Bassi, Flávio V. Loures, Vera L. G. Calich

First Outbreak Response Using an Oral Cholera Vaccine in Africa: Vaccine Coverage, Acceptability and Surveillance of Adverse Events, Guinea, 2012

Francisco J. Luquero, Lise Grout, Iza Ciglenecki, Keita Sakoba, Bala Traore, Melat Heile, Alpha Amadou Dialo, Christian Itama, Micaela Serafini, Dominique Legros, Rebecca F. Grais

Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trial

Stefanie Knopp, Bobbie Person, Shaali M. Ame, Khalfan A. Mohammed, Said M. Ali, I. Simba Khamis, Muriel Rabone, Fiona Allan, Anouk Gouvras, Lynsey Blair, Alan Fenwick, Jürg Utzinger, David Rollinson

How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Children

Jacqueline Bua, Bibiana J. Volta, Alina E. Perrone, Karenina Scollo, Elsa B. Velázquez, Andres M. Ruiz, Ana M. De Rissio, Rita L. Cardoni

Cellular Growth and Mitochondrial Ultrastructure of Leishmania (Viannia) braziliensis Promastigotes Are Affected by the Iron Chelator 2,2-Dipyridyl

Camila Mesquita-Rodrigues, Rubem F. S. Menna-Barreto, Leonardo Sabóia-Vahia, Silvia A. G. Da-Silva, Elen M. de Souza, Mariana C. Waghabi, Patrícia Cuervo, José B. De Jesus

Ongoing Spillover of Hantaan and Gou Hantaviruses from Rodents Is Associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in China

Wen Wang, Miao-Ruo Wang, Xian-Dan Lin, Wen-Ping Guo, Ming-Hui Li, Sheng-Hua Mei, Zhao-Mei Li, Mei-Li Cong, Rui-Lan Jiang, Run-Hong Zhou, Edward C. Holmes, Alexander Plyusnin, Yong-Zhen Zhang

Barriers to Treatment Access for Chagas Disease in Mexico

Jennifer M. Manne, Callae S. Snively, Janine M. Ramsey, Marco Ocampo Salgado, Till Bärnighausen, Michael R. Reich

Human Neutrophil Peptide-1 (HNP-1): A New Anti-Leishmanial Drug Candidate

Sara Dabirian, Yasaman Taslimi, Farnaz Zahedifard, Elham Gholami, Fatemeh Doustdari, Mahdieh Motamedirad, Shohreh Khatami, Kayhan Azadmanesh, Susanne Nylen, Sima Rafati

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Juan Carlos Pizarro, Tanya Hills, Guillermo Senisterra, Amy K. Wernimont, Claire Mackenzie, Neil R. Norcross, Michael A. J. Ferguson, Paul G. Wyatt, Ian H. Gilbert, Raymond Hui

Multilocus Analysis of Divergence and Introgression in Sympatric and Allopatric Sibling Species of the Lutzomyia longipalpis Complex in Brazil

Alejandra S. Araki, Gabriel E. M. Ferreira, Camila J. Mazzoni, Nataly A. Souza, Ricardo C. Machado, Rafaela V. Bruno, Alexandre A. Peixoto

Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approach

Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner

Glyburide Reduces Bacterial Dissemination in a Mouse Model of Melioidosis

Gavin C. K. W. Koh, Tassili A. Weehuizen, Katrin Breitbach, Kathrin Krause, Hanna K. de Jong, Liesbeth M. Kager, Arjan J. Hoogendijk, Antje Bast, Sharon J. Peacock, Tom van der Poll, Ivo Steinmetz, W. Joost Wiersinga

Effect of Maternal Schistosoma mansoni Infection and Praziquantel Treatment During Pregnancy on Schistosoma mansoni Infection and Immune Responsiveness among Offspring at Age Five Years

Robert Tweyongyere, Peter Naniima, Patrice A. Mawa, Frances M. Jones, Emily L. Webb, Stephen Cose, David W. Dunne, Alison M. Elliott

Diagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samples

Patrick Mitashi, Epco Hasker, Dieudonné Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Büscher, Marleen Boelaert, Stijn Deborggraeve

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

Fabrice E. Graf, Philipp Ludin, Tanja Wenzler, Marcel Kaiser, Reto Brun, Patient Pati Pyana, Philippe Büscher, Harry P. de Koning, David Horn, Pascal Mäser

Responses of Murine and Human Macrophages to Leptospiral Infection: A Study Using Comparative Array Analysis

Feng Xue, Xinghui Zhao, Yingchao Yang, Jinping Zhao, Yutao Yang, Yongguo Cao, Cailing Hong, Yuan Liu, Lan Sun, Minjun Huang, Junchao Gu

CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Tomoo Sato, Ariella Coler-Reilly, Atae Utsunomiya, Natsumi Araya, Naoko Yagishita, Hitoshi Ando, Junji Yamauchi, Eisuke Inoue, Takahiko Ueno, Yasuhiro Hasegawa, Kusuki Nishioka, Toshihiro Nakajima, Steven Jacobson, Shuji Izumo, Yoshihisa Yamano

The Dispersal Ecology of Rhodesian Sleeping Sickness Following Its Introduction to a New Area

Nicola A. Wardrop, Eric M. Fèvre, Peter M. Atkinson, Susan C. Welburn

Invasive Non-Typhoidal Salmonella Typhimurium ST313 Are Not Host-Restricted and Have an Invasive Phenotype in Experimentally Infected Chickens

Bryony N. Parsons, Suzanne Humphrey, Anne Marie Salisbury, Julia Mikoleit, Jay C. D. Hinton, Melita A. Gordon, Paul Wigley

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

Valeria P. Sülsen, Silvia I. Cazorla, Fernanda M. Frank, Laura C. Laurella, Liliana V. Muschietti, Cesar A. Catalán, Virginia S. Martino, Emilio L. Malchiodi

Identification of Conserved and HLA Promiscuous DENV3 T-Cell Epitopes

Eduardo J. M. Nascimento, Robbie B. Mailliard, Asif M. Khan, John Sidney, Alessandro Sette, Nicole Guzman, Michael Paulaitis, Andréa Barbosa de Melo, Marli T. Cordeiro, Laura V. G. Gil, Françoir Lemonnier, Charles Rinaldo, J. Thomas August, Ernesto T. A. Marques Jr

The Incubation Period of Buruli Ulcer (Mycobacterium ulcerans Infection)

Jason A. Trubiano, Caroline J. Lavender, Janet A. M. Fyfe, Simone Bittmann, Paul D. R. Johnson

Proteomic Analysis of the Excretory-Secretory Products from Larval Stages of Ascaris suum Reveals High Abundance of Glycosyl Hydrolases

Tao Wang, Katleen Van Steendam, Maarten Dhaenens, Johnny Vlaminck, Dieter Deforce, Aaron R. Jex, Robin B. Gasser, Peter Geldhof

Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans

Jason S. Lehmann, Derrick E. Fouts, Daniel H. Haft, Anthony P. Cannella, Jessica N. Ricaldi, Lauren Brinkac, Derek Harkins, Scott Durkin, Ravi Sanka, Granger Sutton, Angelo Moreno, Joseph M. Vinetz, Michael A. Matthias

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

Virginia M. Gonçalves, Kely C. Matteucci, Carina L. Buzzo, Bruna H. Miollo, Danny Ferrante, Ana C. Torrecilhas, Mauricio M. Rodrigues, Jose M. Alvarez, Karina R. Bortoluci

MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection

Julien Lemaire, Ghada Mkannez, Fatma Z. Guerfali, Cindy Gustin, Hanène Attia, Rabiaa M. Sghaier, Koussay Dellagi, Dhafer Laouini, Patricia Renard , Sysco-Consortium