PLoS Neglected Tropical Diseases

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Table of Contents | August 2010

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Red fluorescence of two transgenic Aedes albopictus larvae.

Both larvae carry an attP docking site integrated into the genome via piggyBac-mediated germline transformation using a cyan fluorescent marker (see article by Labbé et al., doi:10.1371/journal.pntd.0000788). The top larva also carries a 3xP3-DsRed2 marker—leading to expression of DsRed2 red fluorescent protein and hence prominent red fluorescence in the eyes and optic nerve—integrated into the attP site via PhiC31-mediated site-specific integration. Development of gene transfer technology for Aedes albopictus is a key step in the study and control of this invasive species using novel molecular techniques and genetic control strategies.

Image Credit: Geneviève Labbé/Oxitec Ltd.

Editorial

Neglected Tropical Disease Control in the “Post-American World”

Peter J. Hotez

Review

Coronary Microvascular Disease in Chronic Chagas Cardiomyopathy Including an Overview on History, Pathology, and Other Proposed Pathogenic Mechanisms

Marcos A. Rossi, Herbert B. Tanowitz, Lygia M. Malvestio, Mara R. Celes, Erica C. Campos, Valdecir Blefari, Cibele M. Prado

Research Articles

Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, Ivo C. S. I. Tjia, Nicholas P. Day, Sharon J. Peacock, Sandrine Florquin, Tom van der Poll

Metabolic Changes Reveal the Development of Schistosomiasis in Mice

Junfang Wu, Wenxin Xu, Zhenping Ming, Huifen Dong, Huiru Tang, Yulan Wang

A Simple Colorimetric Assay for Specific Detection of Glutathione-S Transferase Activity Associated with DDT Resistance in Mosquitoes

Evangelia Morou, Andrew J. Dowd, Shavanti Rajatileka, Andrew Steven, Janet Hemingway, Hilary Ranson, Mark Paine, John Vontas

Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Jia-Li Wang, Jun-Lei Zhang, Wei Chen, Xiao-Feng Xu, Na Gao, Dong-Ying Fan, Jing An

Functional Genome Annotation by Combined Analysis across Microarray Studies of Trypanosoma brucei

Hamed Shateri Najafabadi, Reza Salavati

Multi-Country Evaluation of the Sensitivity and Specificity of Two Commercially-Available NS1 ELISA Assays for Dengue Diagnosis

Maria G. Guzman, Thomas Jaenisch, Roger Gaczkowski, Vo Thi Ty Hang, Shamala Devi Sekaran, Axel Kroeger, Susana Vazquez, Didye Ruiz, Eric Martinez, Juan C. Mercado, Angel Balmaseda, Eva Harris, Efren Dimano, Prisca Susan A. Leano, Sutee Yoksan, Elci Villegas, Herminia Benduzu, Iris Villalobos, Jeremy Farrar, Cameron P. Simmons

The Onchocerca volvulus Cysteine Proteinase Inhibitor, Ov-CPI-2, Is a Target of Protective Antibody Response That Increases with Age

Fidelis Cho-Ngwa, Jing Liu, Sara Lustigman

Establishment of Fruit Bat Cells (Rousettus aegyptiacus) as a Model System for the Investigation of Filoviral Infection

Verena Krähling, Olga Dolnik, Larissa Kolesnikova, Jonas Schmidt-Chanasit, Ingo Jordan, Volker Sandig, Stephan Günther, Stephan Becker

Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1

Jacob D. Durrant, Laurence Hall, Robert V. Swift, Melissa Landon, Achim Schnaufer, Rommie E. Amaro

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

Gregory J. Crowther, Dhanasekaran Shanmugam, Santiago J. Carmona, Maria A. Doyle, Christiane Hertz-Fowler, Matthew Berriman, Solomon Nwaka, Stuart A. Ralph, David S. Roos, Wesley C. Van Voorhis, Fernán Agüero

Neurocysticercosis, a Persisting Health Problem in Mexico

Agnès Fleury, Jael Moreno García, Paulina Valdez Aguerrebere, María de Sayve Durán, Paola Becerril Rodríguez, Carlos Larralde, Edda Sciutto

piggybac- and PhiC31-Mediated Genetic Transformation of the Asian Tiger Mosquito, Aedes albopictus (Skuse)

Geneviève M. C. Labbé, Derric D. Nimmo, Luke Alphey

Interactions between Global Health Initiatives and Country Health Systems: The Case of a Neglected Tropical Diseases Control Program in Mali

Anna Cavalli, Sory I. Bamba, Mamadou N. Traore, Marleen Boelaert, Youssouf Coulibaly, Katja Polman, Marjan Pirard, Monique Van Dormael

Targeting Trachoma Control through Risk Mapping: The Example of Southern Sudan

Archie C. A. Clements, Lucia W. Kur, Gideon Gatpan, Jeremiah M. Ngondi, Paul M. Emerson, Mounir Lado, Anthony Sabasio, Jan H. Kolaczinski

The Echinococcus granulosus Antigen B Gene Family Comprises at Least 10 Unique Genes in Five Subclasses Which Are Differentially Expressed

Wenbao Zhang, Jun Li, Malcolm K. Jones, Zhuangzhi Zhang, Li Zhao, David Blair, Donald Peter McManus

A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults

Vianney Tricou, Nguyet Nguyen Minh, Toi Pham Van, Sue J. Lee, Jeremy Farrar, Bridget Wills, Hien Tinh Tran, Cameron P. Simmons

A Nuclear Family A DNA Polymerase from Entamoeba histolytica Bypasses Thymine Glycol

Guillermo Pastor-Palacios, Elisa Azuara-Liceaga, Luis G. Brieba

Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000–2007

Brett M. Forshey, Carolina Guevara, V. Alberto Laguna-Torres, Manuel Cespedes, Jorge Vargas, Alberto Gianella, Efrain Vallejo, César Madrid, Nicolas Aguayo, Eduardo Gotuzzo, Victor Suarez, Ana Maria Morales, Luis Beingolea, Nora Reyes, Juan Perez, Monica Negrete, Claudio Rocha, Amy C. Morrison, Kevin L. Russell, Patrick J. Blair, James G. Olson, Tadeusz J. Kochel

Spatiotemporal Trends and Climatic Factors of Hemorrhagic Fever with Renal Syndrome Epidemic in Shandong Province, China

Li-Qun Fang, Xian-Jun Wang, Song Liang, Yan-Li Li, Shao-Xia Song, Wen-Yi Zhang, Quan Qian, Ya-Pin Li, Lan Wei, Zhi-Qiang Wang, Hong Yang, Wu-Chun Cao

FMRFamide-Like Peptides (FLPs) Enhance Voltage-Gated Calcium Currents to Elicit Muscle Contraction in the Human Parasite Schistosoma mansoni

Ekaterina Novozhilova, Michael J. Kimber, Hai Qian, Paul McVeigh, Alan P. Robertson, Mostafa Zamanian, Aaron G. Maule, Tim A. Day

A Major Role for Mammals in the Ecology of Mycobacterium ulcerans

Janet A. M. Fyfe, Caroline J. Lavender, Kathrine A. Handasyde, Alistair R. Legione, Carolyn R. O'Brien, Timothy P. Stinear, Sacha J. Pidot, Torsten Seemann, M. Eric Benbow, John R. Wallace, Christina McCowan, Paul D. R. Johnson

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. I. Parasitological, Hematological and Pathological Parameters

Nathalie Chamond, Alain Cosson, Marie Christine Blom-Potar, Grégory Jouvion, Simon D'Archivio, Mathieu Medina, Sabrina Droin-Bergère, Michel Huerre, Sophie Goyard, Paola Minoprio

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. II. Immunobiological Dysfunctions

Marie Christine Blom-Potar, Nathalie Chamond, Alain Cosson, Grégory Jouvion, Sabrina Droin-Bergère, Michel Huerre, Paola Minoprio

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

Lisa Sharling, Xiaoping Liu, Deviprasad R. Gollapalli, Sushil K. Maurya, Lizbeth Hedstrom, Boris Striepen

Comparison of Microscopy and Alamar Blue Reduction in a Larval Based Assay for Schistosome Drug Screening

Nuha R. Mansour, Quentin D. Bickle

Purification and Functional Characterisation of Rhiminopeptidase A, a Novel Aminopeptidase from the Venom of Bitis gabonica rhinoceros

Sakthivel Vaiyapuri, Simon C. Wagstaff, Kimberley A. Watson, Robert A. Harrison, Jonathan M. Gibbins, E. Gail Hutchinson

Prophylactic Efficacy of TcVac2 against Trypanosoma cruzi in Mice

Shivali Gupta, Nisha Jain Garg

Etiology of Diarrhea in Older Children, Adolescents and Adults: A Systematic Review

Christa L. Fischer Walker, David Sack, Robert E. Black

Prediction of Dengue Disease Severity among Pediatric Thai Patients Using Early Clinical Laboratory Indicators

James A. Potts, Robert V. Gibbons, Alan L. Rothman, Anon Srikiatkhachorn, Stephen J. Thomas, Pra-on Supradish, Stephenie C. Lemon, Daniel H. Libraty, Sharone Green, Siripen Kalayanarooj

Serodiagnosis of Echinococcus spp. Infection: Explorative Selection of Diagnostic Antigens by Peptide Microarray

Claudia List, Weihong Qi, Eva Maag, Bruno Gottstein, Norbert Müller, Ingrid Felger

Screening Mosquito House Entry Points as a Potential Method for Integrated Control of Endophagic Filariasis, Arbovirus and Malaria Vectors

Sheila B. Ogoma, Dickson W. Lweitoijera, Hassan Ngonyani, Benjamin Furer, Tanya L. Russell, Wolfgang R. Mukabana, Gerry F. Killeen, Sarah J. Moore

The International Limits and Population at Risk of Plasmodium vivax Transmission in 2009

Carlos A. Guerra, Rosalind E. Howes, Anand P. Patil, Peter W. Gething, Thomas P. Van Boeckel, William H. Temperley, Caroline W. Kabaria, Andrew J. Tatem, Bui H. Manh, Iqbal R. F. Elyazar, J. Kevin Baird, Robert W. Snow, Simon I. Hay

The Role of Imported Cases and Favorable Meteorological Conditions in the Onset of Dengue Epidemics

Chuin-Shee Shang, Chi-Tai Fang, Chung-Ming Liu, Tzai-Hung Wen, Kun-Hsien Tsai, Chwan-Chuen King

Diagnostic Accuracy of the Leishmania OligoC-TesT and NASBA-Oligochromatography for Diagnosis of Leishmaniasis in Sudan

Alfarazdeg A. Saad, Nuha G. Ahmed, Osman S. Osman, Ahmed Almustafa Al-Basheer, Awad Hamad, Stijn Deborggraeve, Philippe Büscher, Gerard J. Schoone, Henk D. Schallig, Thierry Laurent, Ahmed Haleem, Omran F. Osman, Ahmed Mohamedain Eltom, Mustafa I. Elbashir, Sayda El-Safi

Characterization of the Dispersal of Non-Domiciliated Triatoma dimidiata through the Selection of Spatially Explicit Models

Corentin Barbu, Eric Dumonteil, Sébastien Gourbière

Cross-Reactivity of Antibodies against Leptospiral Recurrent Uveitis-Associated Proteins A and B (LruA and LruB) with Eye Proteins

Ashutosh Verma, Pawan Kumar, Kelly Babb, John F. Timoney, Brian Stevenson

Transmission of Schistosoma japonicum in Marshland and Hilly Regions of China: Parasite Population Genetic and Sibship Structure

Da-Bing Lu, James W. Rudge, Tian-Ping Wang, Christl A. Donnelly, Guo-Ren Fang, Joanne P. Webster

Trichomonas Transmembrane Cyclases Result from Massive Gene Duplication and Concomitant Development of Pseudogenes

Jike Cui, Suchismita Das, Temple F. Smith, John Samuelson

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