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Table of Contents: June 2015

COVER

In situ Disinfection of Hospital Wastewaters.

Image Credit: Sozzi et al.
Issue Image

The operation of a health care facility, such as a cholera or Ebola treatment center in an emergency setting, results in the production of pathogen-laden wastewaters that may potentially lead to onward transmission of the disease. The research presented here evaluated the design and operation of a novel treatment system, successfully used by Médecins Sans Frontières in Haiti to disinfect CTC wastewaters in situ, eliminating the need for road haulage and disposal of the waste to a poorly-managed hazardous waste facility, thereby providing an effective barrier to disease transmission through a novel but simple sanitary intervention. Sozzi et al.

Editorial

Viewpoints

Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer

Simon L. Conti, Jared Honeycutt, Justin I. Odegaard, Mark L. Gonzalgo, Michael H. Hsieh

Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment

Analía I. Porrás, Zaida E. Yadon, Jaime Altcheh, Constança Britto, Gabriela C. Chaves, Laurence Flevaud, Olindo Assis Martins-Filho, Isabela Ribeiro, Alejandro G. Schijman, Maria Aparecida Shikanai-Yasuda, Sergio Sosa-Estani, Eric Stobbaerts, Fabio Zicker

Policy Platform

The Case for Improved Diagnostic Tools to Control Ebola Virus Disease in West Africa and How to Get There

Arlene C. Chua, Jane Cunningham, Francis Moussy, Mark D. Perkins, Pierre Formenty

Reviews

Control of Dog Mediated Human Rabies in Haiti: No Time to Spare

Max F. Millien, Jocelyne B. Pierre-Louis, Ryan Wallace, Eduardo Caldas, Jean M. Rwangabgoba, Jean L. Poncelet, Ottorino Cosivi, Victor J. Del Rio Vilas

What Factors Might Have Led to the Emergence of Ebola in West Africa?

Kathleen A. Alexander, Claire E. Sanderson, Madav Marathe, Bryan L. Lewis, Caitlin M. Rivers, Jeffrey Shaman, John M. Drake, Eric Lofgren, Virginia M. Dato, Marisa C. Eisenberg, Stephen Eubank

Research Articles

Plasmodium vivax Diversity and Population Structure across Four Continents

Cristian Koepfli, Priscila T. Rodrigues, Tiago Antao, Pamela Orjuela-Sánchez, Peter Van den Eede, Dionicia Gamboa, Nguyen van Hong, Jorge Bendezu, Annette Erhart, Céline Barnadas, Arsène Ratsimbasoa, Didier Menard, Carlo Severini, Michela Menegon, Bakri Y. M. Nour, Nadira Karunaweera, Ivo Mueller, Marcelo U. Ferreira, Ingrid Felger

Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws

Michael Marks, Samantha Katz, Kai-Hua Chi, Ventis Vahi, Yongcheng Sun, David C. Mabey, Anthony W. Solomon, Cheng Y. Chen, Allan Pillay

Identification of Burkholderia pseudomallei Near-Neighbor Species in the Northern Territory of Australia

Jennifer L. Ginther, Mark Mayo, Stephanie D. Warrington, Mirjam Kaestli, Travis Mullins, David M. Wagner, Bart J. Currie, Apichai Tuanyok, Paul Keim

A Rodent Model of Chikungunya Virus Infection in RAG1 -/- Mice, with Features of Persistence, for Vaccine Safety Evaluation

Robert L. Seymour, A. Paige Adams, Grace Leal, Maria D. H. Alcorn, Scott C. Weaver

Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children

Gemma Louise Kay, Andrew Millard, Martin J. Sergeant, Nicholas Midzi, Reggis Gwisai, Takafira Mduluza, Alasdair Ivens, Norman Nausch, Francisca Mutapi, Mark Pallen

Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development

Tiffany M. Mott, Sudhamathi Vijayakumar, Elena Sbrana, Janice J. Endsley, Alfredo G. Torres

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection

Marina Tiemi Shio, Jan Gregor Christian, Jee Yong Jung, Kwang-Poo Chang, Martin Olivier

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery

Sean Ekins, Jair Lage de Siqueira-Neto, Laura-Isobel McCall, Malabika Sarker, Maneesh Yadav, Elizabeth L. Ponder, E. Adam Kallel, Danielle Kellar, Steven Chen, Michelle Arkin, Barry A. Bunin, James H. McKerrow, Carolyn Talcott

Three Gorges Dam: Impact of Water Level Changes on the Density of Schistosome-Transmitting Snail Oncomelania hupensis in Dongting Lake Area, China

Jin-Yi Wu, Yi-Biao Zhou, Yue Chen, Song Liang, Lin-Han Li, Sheng-Bang Zheng, Shao-ping Zhu, Guang-Hui Ren, Xiu-Xia Song, Qing-Wu Jiang

Snakebites in Two Rural Districts in Lao PDR: Community-Based Surveys Disclose High Incidence of an Invisible Public Health Problem

Inthanomchanh Vongphoumy, Panom Phongmany, Sengdao Sydala, Nouda Prasith, Ralf Reintjes, Joerg Blessmann

Wolbachia Reduces the Transmission Potential of Dengue-Infected Aedes aegypti

Yixin H. Ye, Alison M. Carrasco, Francesca D. Frentiu, Stephen F. Chenoweth, Nigel W. Beebe, Andrew F. van den Hurk, Cameron P. Simmons, Scott L. O’Neill, Elizabeth A. McGraw

Relationship between Distinct African Cholera Epidemics Revealed via MLVA Haplotyping of 337 Vibrio cholerae Isolates

Sandra Moore, Berthe Miwanda, Adodo Yao Sadji, Hélène Thefenne, Fakhri Jeddi, Stanislas Rebaudet, Hilde de Boeck, Bawimodom Bidjada, Jean-Jacques Depina, Didier Bompangue, Aaron Aruna Abedi, Lamine Koivogui, Sakoba Keita, Eric Garnotel, Pierre-Denis Plisnier, Raymond Ruimy, Nicholas Thomson, Jean-Jacques Muyembe, Renaud Piarroux

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa

Mathew A. Beale, Wilber Sabiiti, Emma J. Robertson, Karen M. Fuentes-Cabrejo, Simon J. O’Hanlon, Joseph N. Jarvis, Angela Loyse, Graeme Meintjes, Thomas S. Harrison, Robin C. May, Matthew C. Fisher, Tihana Bicanic

Canine Antibodies against Salivary Recombinant Proteins of Phlebotomus perniciosus: A Longitudinal Study in an Endemic Focus of Canine Leishmaniasis

Tatiana Kostalova, Tereza Lestinova, Petra Sumova, Michaela Vlkova, Iva Rohousova, Eduardo Berriatua, Gaetano Oliva, Eleonora Fiorentino, Aldo Scalone, Marina Gramiccia, Luigi Gradoni, Petr Volf

A Systematic Review of the Mortality from Untreated Leptospirosis

Andrew J. Taylor, Daniel H. Paris, Paul N. Newton

Soil-Transmitted Helminths in Southwestern China: A Cross-Sectional Study of Links to Cognitive Ability, Nutrition, and School Performance among Children

Chengfang Liu, Renfu Luo, Hongmei Yi, Linxiu Zhang, Shaoping Li, Yunli Bai, Alexis Medina, Scott Rozelle, Scott Smith, Guofei Wang, Jujun Wang

Diagnostic Accuracy of Recombinant Immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines

Emi Kitashoji, Nobuo Koizumi, Talitha Lea V. Lacuesta, Daisuke Usuda, Maricel R. Ribo, Edith S. Tria, Winston S. Go, Maiko Kojiro, Christopher M. Parry, Efren M. Dimaano, Jose B. Villarama, Makoto Ohnishi, Motoi Suzuki, Koya Ariyoshi

Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil

Felipe Jules de Araujo, Luan Diego Oliveira da Silva, Tirza Gabrielle Mesquita, Suzana Kanawati Pinheiro, Wonei de Seixas Vital, Anette Chrusciak-Talhari, Jorge Augusto de Oliveira Guerra, Sinésio Talhari, Rajendranath Ramasawmy

Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta

Ricardo Ataíde, Oscar Murillo, Jamille G. Dombrowski, Rodrigo M. Souza, Flávia A. Lima, Giselle F. M. C. Lima, Angélica D. Hristov, Suiane C. N. Valle, Silvia M. Di Santi, Sabrina Epiphanio, Claudio R. F. Marinho

Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness

Charles D. Kato, Vincent P. Alibu, Ann Nanteza, Claire M. Mugasa, Enock Matovu

Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection

Jiseon Yang, Jennifer Barrila, Kenneth L. Roland, Jacquelyn Kilbourne, C. Mark Ott, Rebecca J. Forsyth, Cheryl A. Nickerson

Buruli Ulcer Disease and Its Association with Land Cover in Southwestern Ghana

Jianyong Wu, Petra Tschakert, Erasmus Klutse, David Ferring, Vincent Ricciardi, Heidi Hausermann, Joseph Oppong, Erica A. H. Smithwick

Trypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection?

Juliana Barreto-de-Albuquerque, Danielle Silva-dos-Santos, Ana Rosa Pérez, Luiz Ricardo Berbert, Eliane de Santana-van-Vliet, Désio Aurélio Farias-de-Oliveira, Otacilio C. Moreira, Eduardo Roggero, Carla Eponina de Carvalho-Pinto, José Jurberg, Vinícius Cotta-de-Almeida, Oscar Bottasso, Wilson Savino, Juliana de Meis

Toward Measuring Schistosoma Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion

Piero L. Olliaro, Michel Vaillant, Aïssatou Diawara, Jean T. Coulibaly, Amadou Garba, Jennifer Keiser, Charles H. King, Stefanie Knopp, Aly Landouré, Eliézer K. N’Goran, Giovanna Raso, Alexandra U. Scherrer, José Carlos Sousa-Figueiredo, Katarina Stete, Xiao-Nong Zhou, Jürg Utzinger

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes

Isabela Cunha Navarro, Frederico Moraes Ferreira, Helder I. Nakaya, Monique Andrade Baron, Gláucia Vilar-Pereira, Isabela Resende Pereira, Ana Maria Gonçalves Silva, Juliana Monte Real, Thales De Brito, Christophe Chevillard, Joseli Lannes-Vieira, Jorge Kalil, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira

BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge

Valentina Franceschi, Scott Parker, Sarah Jacca, Ryan W. Crump, Konstantin Doronin, Edguardo Hembrador, Daniela Pompilio, Giulia Tebaldi, Ryan D. Estep, Scott W. Wong, Mark R. Buller, Gaetano Donofrio

Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress

Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C. Campos, Julia B. Miranda, Ceres L. Alves, Carlos R. Machado, Richard McCulloch, Santuza M. R. Teixeira

Autochthonous Chikungunya Transmission and Extreme Climate Events in Southern France

David Roiz, Philippe Boussès, Frédéric Simard, Christophe Paupy, Didier Fontenille

Acceptability and Willingness-to-Pay for a Hypothetical Ebola Virus Vaccine in Nigeria

Maduka Donatus Ughasoro, Dorothy Omono Esangbedo, Beckie Nnenna Tagbo, Ijeoma Chigozie Mejeha

Diverse Genotypes of Yersinia pestis Caused Plague in Madagascar in 2007

Julia M. Riehm, Michaela Projahn, Amy J. Vogler, Minoaerisoa Rajerison, Genevieve Andersen, Carina M. Hall, Thomas Zimmermann, Rahelinirina Soanandrasana, Voahangy Andrianaivoarimanana, Reinhard K. Straubinger, Roxanne Nottingham, Paul Keim, David M. Wagner, Holger C. Scholz

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

Franklin R. Toapanta, Paula J. Bernal, Stephanie Fresnay, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Gordon Dougan, Brian Angus, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein

Prioritising Infectious Disease Mapping

David M. Pigott, Rosalind E. Howes, Antoinette Wiebe, Katherine E. Battle, Nick Golding, Peter W. Gething, Scott F. Dowell, Tamer H. Farag, Andres J. Garcia, Ann M. Kimball, L. Kendall Krause, Craig H. Smith, Simon J. Brooker, Hmwe H. Kyu, Theo Vos, Christopher J. L. Murray, Catherine L. Moyes, Simon I. Hay

Airborne Transmission of Melioidosis to Humans from Environmental Aerosols Contaminated with B. pseudomallei

Pei-Shih Chen, Yao-Shen Chen, Hsi-Hsun Lin, Pei-Ju Liu, Wei-Fan Ni, Pei-Tan Hsueh, Shih-Hsiung Liang, Chialin Chen, Ya-Lei Chen

Monitoring the Progress towards the Elimination of Gambiense Human African Trypanosomiasis

Pere P. Simarro, Giuliano Cecchi, José R. Franco, Massimo Paone, Abdoulaye Diarra, Gerardo Priotto, Raffaele C. Mattioli, Jean G. Jannin

Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial

Sina Brückner, Selidji T. Agnandji, Stefan Berberich, Emmanuel Bache, José F. Fernandes, Brunhilde Schweiger, Marguerite Massinga Loembe, Thomas Engleitner, Bertrand Lell, Benjamin Mordmüller, Ayola A. Adegnika, Maria Yazdanbakhsh, Peter G. Kremsner, Meral Esen

Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen

Ghalia Boubaker, Andrew Hemphill, Cristina Olivia Huber, Markus Spiliotis, Hamouda Babba, Bruno Gottstein

Exposure to an Indoor Cooking Fire and Risk of Trachoma in Children of Kongwa, Tanzania

Andrea I. Zambrano, Beatriz E. Muñoz, Harran Mkocha, Sheila K. West

Locally Confined Clonal Complexes of Mycobacterium ulcerans in Two Buruli Ulcer Endemic Regions of Cameroon

Miriam Bolz, Martin W. Bratschi, Sarah Kerber, Jacques C. Minyem, Alphonse Um Boock, Moritz Vogel, Pierre Franklin Bayi, Thomas Junghanss, Daniela Brites, Simon R. Harris, Julian Parkhill, Gerd Pluschke, Araceli Lamelas Cabello

Antiviral Biologic Produced in DNA Vaccine/Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure

Nicole Haese, Rebecca L. Brocato, Thomas Henderson, Matthew L. Nilles, Steve A. Kwilas, Matthew D. Josleyn, Christopher D. Hammerbeck, James Schiltz, Michael Royals, John Ballantyne, Jay W. Hooper, David S. Bradley

Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis

Li Na Liu, Zhong Quan Wang, Xi Zhang, Peng Jiang, Xin Qi, Ruo Dan Liu, Zi Fang Zhang, Jing Cui

Optimization of a Novel Non-invasive Oral Sampling Technique for Zoonotic Pathogen Surveillance in Nonhuman Primates

Tierra Smiley Evans, Peter A. Barry, Kirsten V. Gilardi, Tracey Goldstein, Jesse D. Deere, Joseph Fike, JoAnn Yee, Benard J Ssebide, Dibesh Karmacharya, Michael R. Cranfield, David Wolking, Brett Smith, Jonna A. K. Mazet, Christine K. Johnson

Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission

Federico Costa, Elsio A. Wunder Jr., Daiana De Oliveira, Vimla Bisht, Gorete Rodrigues, Mitermayer G. Reis, Albert I. Ko, Mike Begon, James E. Childs

Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo

Nanikaly Moyen, Laurence Thirion, Petra Emmerich, Amelia Dzia-Lepfoundzou, Hervé Richet, Yannik Boehmann, Yannick Dimi, Pierre Gallian, Ernest A. Gould, Stephan Günther, Xavier de Lamballerie

Cohorting Dengue Patients Improves the Quality of Care and Clinical Outcome

Lucy C. S. Lum, Sharifah Faridah Syed Omar, Sasheela Sri La Sri Ponnampalavanar, Lian H. Tan, Shamala Devi Sekaran, Adeeba Kamarulzaman

Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach

Mathias Beig, Frank Oellien, Linnéa Garoff, Sandra Noack, R. Luise Krauth-Siegel, Paul M. Selzer

Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease

Paul J. Converse, Sandeep Tyagi, Yalan Xing, Si-Yang Li, Yoshito Kishi, John Adamson, Eric L. Nuermberger, Jacques H. Grosset

Human Immunodeficiency Virus, Antiretroviral Therapy and Markers of Lymphatic Filariasis Infection: A Cross-sectional Study in Rural Northern Malawi

Terence Tafatatha, Miriam Taegtmeyer, Bagrey Ngwira, Amos Phiri, Mariot Kondowe, Wilson Piston, Anna Molesworth, Ndoliwe Kayuni, Olivier Koole, Amelia Crampin, John Horton, Neil French

Updated Global Burden of Cholera in Endemic Countries

Mohammad Ali, Allyson R. Nelson, Anna Lena Lopez, David A. Sack

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

Pavla Fajtová, Saša Štefanić, Martin Hradilek, Jan Dvořák, Jiří Vondrášek, Adéla Jílková, Lenka Ulrychová, James H. McKerrow, Conor R. Caffrey, Michael Mareš, Martin Horn

Human-Mediated Marine Dispersal Influences the Population Structure of Aedes aegypti in the Philippine Archipelago

Eugenio Fonzi, Yukiko Higa, Arlene G. Bertuso, Kyoko Futami, Noboru Minakawa

A Multi-country Study of the Household Willingness-to-Pay for Dengue Vaccines: Household Surveys in Vietnam, Thailand, and Colombia

Jung-Seok Lee, Vittal Mogasale, Jacqueline K. Lim, Mabel Carabali, Chukiat Sirivichayakul, Dang Duc Anh, Kang-Sung Lee, Vu Dinh Thiem, Kriengsak Limkittikul, Le Huu Tho, Ivan D. Velez, Jorge E. Osorio, Pornthep Chanthavanich, Luiz J. da Silva, Brian A. Maskery

Leprosy Reactions in Patients Coinfected with HIV: Clinical Aspects and Outcomes in Two Comparative Cohorts in the Amazon Region, Brazil

Carla Andréa Avelar Pires, Fernando Octávio Machado Jucá Neto, Nahima Castelo de Albuquerque, Geraldo Mariano Moraes Macedo, Keila de Nazaré Madureira Batista, Marília Brasil Xavier