Table of Contents: October 2008


Image Credit:
Issue Image
Dengue virus is unable to productively infect dermal-type macrophages.

The image shows a human CD209+ macrophage, in which the dengue virus envelope E protein, fused to green fluorescent protein, is not co-localized with the acidic (red) perinuclear compartments. Envelope acidification is critical to initiate the viral life cycle. IL-10, present in the human skin, is required for the formation of these macrophages. Understanding these infection events shortly after the mosquito bite can help explain why many dengue infections are asymptomatic (see Kwan et al., doi:10.1371/journal.pntd.0000311).

Image Credit: Marion Decossas, Erika Navarro-Sanchez, and Hélène Dumortier



Marring Leishmaniasis: The Stigmatization and the Impact of Cutaneous Leishmaniasis in Pakistan and Afghanistan

Masoom Kassi, Mahwash Kassi, Abaseen Khan Afghan, Rabeea Rehman, Pashtoon Murtaza Kasi

Research Articles

A Simple Scoring System to Differentiate between Relapse and Re-Infection in Patients with Recurrent Melioidosis

Direk Limmathurotsakul, Wipada Chaowagul, Narisara Chantratita, Vanaporn Wuthiekanun, Mayurachat Biaklang, Sarinna Tumapa, Nicholas J. White, Nicholas P. J. Day, Sharon J. Peacock

Web-Based Virtual Microscopy for Parasitology: A Novel Tool for Education and Quality Assurance

Ewert Linder, Mikael Lundin, Cecilia Thors, Marianne Lebbad, Jadwiga Winiecka-Krusnell, Heikki Helin, Byron Leiva, Jorma Isola, Johan Lundin

Controlling Tungiasis in an Impoverished Community: An Intervention Study

Daniel Pilger, Stefan Schwalfenberg, Jörg Heukelbach, Lars Witt, Norbert Mencke, Adak Khakban, Hermann Feldmeier

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

Hui Hong, Emmanuelle Coutanceau, Marion Leclerc, Laxmee Caleechurn, Peter F. Leadlay, Caroline Demangel

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

Peter Steinmann, Xiao-Nong Zhou, Zun-Wei Du, Jin-Yong Jiang, Shu-Hua Xiao, Zhong-Xing Wu, Hui Zhou, Jürg Utzinger

High Throughput Selection of Effective Serodiagnostics for Trypanosoma cruzi infection

Gretchen Cooley, R. Drew Etheridge, Courtney Boehlke, Becky Bundy, D. Brent Weatherly, Todd Minning, Matthew Haney, Miriam Postan, Susana Laucella, Rick L. Tarleton

The Global Programme to Eliminate Lymphatic Filariasis: Health Impact after 8 Years

Eric A. Ottesen, Pamela J. Hooper, Mark Bradley, Gautam Biswas

Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

Nguyen Thi Phuong Lan, Mihoko Kikuchi, Vu Thi Que Huong, Do Quang Ha, Tran Thi Thuy, Vo Dinh Tham, Ha Manh Tuan, Vo Van Tuong, Cao Thi Phi Nga, Tran Van Dat, Toshifumi Oyama, Kouichi Morita, Michio Yasunami, Kenji Hirayama

Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

Fernanda C. Cardoso, Gilson C. Macedo, Elisandra Gava, Gregory T. Kitten, Vitor L. Mati, Alan L. de Melo, Marcelo V. Caliari, Giulliana T. Almeida, Thiago M. Venancio, Sergio Verjovski-Almeida, Sergio C. Oliveira

Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth

Wing-Hong Kwan, Erika Navarro-Sanchez, Hélène Dumortier, Marion Decossas, Hortense Vachon, Flavia Barreto dos Santos, Hervé W. Fridman, Félix A. Rey, Eva Harris, Philippe Despres, Christopher G. Mueller