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Table of Contents: July 2012

COVER

Neglected diseases konzo and neurolathyrism.

Image Credit: Fernand Lambein (Ghent University)
Issue Image

Ethiopian victims of neurolathyrism often make a living from begging at churches in cities, avoiding socioeconomic dependency on their own deprived rural community. The typical symptoms of both konzo and neurolathyrism are scissor gait and walking on the balls of the feet. Some individuals have their toenails worn from dragging their bare feet over the ground. This person was begging at a Coptic church in Addis Ababa. See Diasolua Ngudi et al.

Editorial

Nigeria: “Ground Zero" for the High Prevalence Neglected Tropical Diseases

Peter J. Hotez, Oluwatoyin A. Asojo, Adekunle M. Adesina

Viewpoints

Policy Platform

Alkhurma Viral Hemorrhagic Fever Virus: Proposed Guidelines for Detection, Prevention, and Control in Saudi Arabia

Ziad A. Memish, Shamsudeen F. Fagbo, Abdullah M. Assiri, Pierre Rollin, Ali M. Zaki, Remi Charrel, Chris Mores, Adam MacNeil

A Diagnostics Platform for the Integrated Mapping, Monitoring, and Surveillance of Neglected Tropical Diseases: Rationale and Target Product Profiles

Anthony W. Solomon, Dirk Engels, Robin L. Bailey, Isobel M. Blake, Simon Brooker, Jia-Xu Chen, Jun-Hu Chen, Thomas S. Churcher, Chris J. Drakeley, Tansy Edwards, Alan Fenwick, Michael French, Albis Francesco Gabrielli, Nicholas C. Grassly, Emma M. Harding-Esch, Martin J. Holland, Artemis Koukounari, Patrick J. Lammie, Jacqueline Leslie, David C. Mabey, Mohamed Rhajaoui, W. Evan Secor, J. Russell Stothard, Hu Wei, A. Lee Willingham, Xiao-Nong Zhou, Rosanna W. Peeling

Symposium

Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy—A Case Report from Togo

Marcus Beissner, Ebekalisai Piten, Issaka Maman, Dominik Symank, Moritz Jansson, Jörg Nitschke, Komi Amekuse, Basil Kobara, Franz Wiedemann, Harald Hoffmann, Adolf Diefenhardt, Kossi Badziklou, Abiba Banla Kere, Thomas Löscher, Gisela Bretzel

Research Articles

Activation of Indoleamine 2,3-Dioxygenase in Patients with Scrub Typhus and Its Role in Growth Restriction of Orientia tsutsugamushi

Thanavadee Prachason, Kanittha Konhan, Piyapat Pongnarin, Somruedee Chatsiricharoenkul, Yupin Suputtamongkol, Chanin Limwongse

Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. I. Epidemiology of Symptomatic Acute Dengue Infection in Children, 2006–2009

Arunee Sabchareon, Chukiat Sirivichayakul, Kriengsak Limkittikul, Pornthep Chanthavanich, Saravudh Suvannadabba, Vithaya Jiwariyavej, Wut Dulyachai, Krisana Pengsaa, Harold S. Margolis, G. William Letson

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Shamila S. Gunatilleke, Claudia M. Calvet, Jonathan B. Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C. Engel, Kenny K. H. Ang, Joseph Mulvaney, Steven Chen, Michelle R. Arkin, James H. McKerrow, Larissa M. Podust

Detection of Antibiotic Resistance in Leprosy Using GenoType LepraeDR, a Novel Ready-To-Use Molecular Test

Emmanuelle Cambau, Aurélie Chauffour-Nevejans, Liana Tejmar-Kolar, Masanori Matsuoka, Vincent Jarlier

Evaluation of Circulating Cathodic Antigen (CCA) Urine-Tests for Diagnosis of Schistosoma mansoni Infection in Cameroon

Louis-Albert Tchuem Tchuenté, Césaire Joris Kueté Fouodo, Romuald Isaka Kamwa Ngassam, Laurentine Sumo, Calvine Dongmo Noumedem, Christian Mérimé Kenfack, Nestor Feussom Gipwe, Esther Dankoni Nana, J. Russell Stothard, David Rollinson

Research on Motor Neuron Diseases Konzo and Neurolathyrism: Trends from 1990 to 2010

Delphin Diasolua Ngudi, Yu-Haey Kuo, Marc Van Montagu, Fernand Lambein

Regulatory T Cells Enhance Susceptibility to Experimental Trypanosoma Congolense Infection Independent of Mouse Genetic Background

Ifeoma Okwor, Chukwunonso Onyilagha, Shiby Kuriakose, Zhirong Mou, Ping Jia, Jude E. Uzonna

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

Ross A. Paveley, Nuha R. Mansour, Irene Hallyburton, Leo S. Bleicher, Alex E. Benn, Ivana Mikic, Alessandra Guidi, Ian H. Gilbert, Andrew L. Hopkins, Quentin D. Bickle

Seroprevalence of Chagas Infection in the Donor Population

Ben A. Zaniello, Deborah A. Kessler, Katherine M. Vine, Kathleen M. Grima, Scott A. Weisenberg

Significantly Reduced Intensity of Infection but Persistent Prevalence of Schistosomiasis in a Highly Endemic Region in Mali after Repeated Treatment

Aly Landouré, Robert Dembélé, Seydou Goita, Mamadou Kané, Marjon Tuinsma, Moussa Sacko, Emily Toubali, Michael D. French, Adama D. Keita, Alan Fenwick, Mamadou S. Traoré, Yaobi Zhang

Partnering Parasites: Evidence of Synergism between Heavy Schistosoma haematobium and Plasmodium Species Infections in Kenyan Children

Lia S. Florey, Charles H. King, Melissa K. Van Dyke, Eric M. Muchiri, Peter L. Mungai, Peter A. Zimmerman, Mark L. Wilson

Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini: A Randomized, Single-Blinded Dose-Comparison Trial

Leonore Lovis, Tippi K. Mak, Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong, Youthanavanh Vonghachack, Jennifer Keiser, Penelope Vounatsou, Marcel Tanner, Christoph Hatz, Jürg Utzinger, Peter Odermatt, Kongsap Akkhavong

Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-α in HTLV-1-Associated Myelopathy

Britta Moens, Daniele Decanine, Soraya Maria Menezes, Ricardo Khouri, Gilvanéia Silva-Santos, Giovanni Lopez, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Ramon de Almeida Kruschewsky, Bernardo Galvão-Castro, Anne-Mieke Vandamme, Johan Van Weyenbergh

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

John K. Thuita, Michael Z. Wang, John M. Kagira, Cathrine L. Denton, Mary F. Paine, Raymond E. Mdachi, Grace A. Murilla, Shelley Ching, David W. Boykin, Richard R. Tidwell, James E. Hall, Reto Brun

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

Anja Kathrin Wege, Christian Florian, Wolfgang Ernst, Nicole Zimara, Ulrike Schleicher, Frank Hanses, Maximilian Schmid, Uwe Ritter

Safety of the Recombinant Cholera Toxin B Subunit, Killed Whole-Cell (rBS-WC) Oral Cholera Vaccine in Pregnancy

Ramadhan Hashim, Ahmed M. Khatib, Godwin Enwere, Jin Kyung Park, Rita Reyburn, Mohammad Ali, Na Yoon Chang, Deok Ryun Kim, Benedikt Ley, Kamala Thriemer, Anna Lena Lopez, John D. Clemens, Jacqueline L. Deen, Sunheang Shin, Christian Schaetti, Raymond Hutubessy, Maria Teresa Aguado, Marie Paule Kieny, David Sack, Stephen Obaro, Attiye J. Shaame, Said M. Ali, Abdul A. Saleh, Lorenz von Seidlein, Mohamed S. Jiddawi

Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study

Raaj S. Mehta, Alejandro Rodriguez, Martha Chico, Irene Guadalupe, Nely Broncano, Carlos Sandoval, Fernanda Tupiza, Edward Mitre, Philip J. Cooper

Complement Inhibitors from Scabies Mites Promote Streptococcal Growth – A Novel Mechanism in Infected Epidermis?

Angela Mika, Simone L. Reynolds, Darren Pickering, David McMillan, Kadaba S. Sriprakash, David J. Kemp, Katja Fischer

Effective Control of Schistosoma haematobium Infection in a Ghanaian Community following Installation of a Water Recreation Area

Karen C. Kosinski, Michael N. Adjei, Kwabena M. Bosompem, Jonathan J. Crocker, John L. Durant, Dickson Osabutey, Jeanine D. Plummer, Miguel J. Stadecker, Anjuli D. Wagner, Mark Woodin, David M. Gute

Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments

Adriana R. Cruz, Lady G. Ramirez, Ana V. Zuluaga, Allan Pillay, Christine Abreu, Carlos A. Valencia, Carson La Vake, Jorge L. Cervantes, Star Dunham-Ems, Richard Cartun, Domenico Mavilio, Justin D. Radolf, Juan C. Salazar

Fine Scale Spatiotemporal Clustering of Dengue Virus Transmission in Children and Aedes aegypti in Rural Thai Villages

In-Kyu Yoon, Arthur Getis, Jared Aldstadt, Alan L. Rothman, Darunee Tannitisupawong, Constantianus J. M. Koenraadt, Thanyalak Fansiri, James W. Jones, Amy C. Morrison, Richard G. Jarman, Ananda Nisalak, Mammen P. Mammen Jr., Suwich Thammapalo, Anon Srikiatkhachorn, Sharone Green, Daniel H. Libraty, Robert V. Gibbons, Timothy Endy, Chusak Pimgate, Thomas W. Scott

Seroprevalence and Risk Factors for Taenia solium Cysticercosis in Rural Pigs of Northern Peru

César M. Jayashi, Gianfranco Arroyo, Marshall W. Lightowlers, Héctor H. García, Silvia Rodríguez, Armando E. Gonzalez

Primary Vaccination with Low Dose Live Dengue 1 Virus Generates a Proinflammatory, Multifunctional T Cell Response in Humans

Janet C. Lindow, Nathan Borochoff-Porte, Anna P. Durbin, Stephen S. Whitehead, Kelly A. Fimlaid, Janice Y. Bunn, Beth D. Kirkpatrick

Podoconiosis in East and West Gojam Zones, Northern Ethiopia

Yordanos B. Molla, Sara Tomczyk, Tsige Amberbir, Abreham Tamiru, Gail Davey

Relationship between Immediate Post-Operative Appearance and 6-Week Operative Outcome in Trichiasis Surgery

Shannath L. Merbs, Jennifer C. Harding, Sandra D. Cassard, Beatriz E. Munoz, Sheila K. West, Emily W. Gower

Kinetics of Antibody Response in BALB/c and C57BL/6 Mice Bitten by Phlebotomus papatasi

Michaela Vlkova, Iva Rohousova, Jitka Hostomska, Lucia Pohankova, Lenka Zidkova, Jan Drahota, Jesus G. Valenzuela, Petr Volf

Unequivocal Identification of Subpopulations in Putative Multiclonal Trypanosoma cruzi Strains by FACs Single Cell Sorting and Genotyping

Helder Magno Silva Valadares, Juliana Ramos Pimenta, Marcela Segatto, Vanja Maria Veloso, Mônica Lúcia Gomes, Egler Chiari, Kenneth John Gollob, Maria Terezinha Bahia, Marta de Lana, Glória Regina Franco, Carlos Renato Machado, Sérgio Danilo Junho Pena, Andréa Mara Macedo

Female-Specific Flightless (fsRIDL) Phenotype for Control of Aedes albopictus

Geneviève M. C. Labbé, Sarah Scaife, Siân A. Morgan, Zoë H. Curtis, Luke Alphey

Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance

Rebecca E. Symula, Jon S. Beadell, Mark Sistrom, Kehinde Agbebakun, Oliver Balmer, Wendy Gibson, Serap Aksoy, Adalgisa Caccone

Cure of Hookworm Infection with a Cysteine Protease Inhibitor

Jon J. Vermeire, Lorine D. Lantz, Conor R. Caffrey

Sensitive and Specific Detection of Trypanosoma cruzi DNA in Clinical Specimens Using a Multi-Target Real-Time PCR Approach

Yvonne Qvarnstrom, Alejandro G. Schijman, Vincent Veron, Christine Aznar, Francis Steurer, Alexandre J. da Silva

Safety and Immunogenicity of rSh28GST Antigen in Humans: Phase 1 Randomized Clinical Study of a Vaccine Candidate against Urinary Schistosomiasis

Gilles Riveau, Dominique Deplanque, Franck Remoué, Anne-Marie Schacht, Hubert Vodougnon, Monique Capron, Michel Thiry, Joseph Martial, Christian Libersa, André Capron

Improved Serodiagnosis of Cystic Echinococcosis Using the New Recombinant 2B2t Antigen

Ana Hernández-González, Saúl Santivañez, Héctor H. García, Silvia Rodríguez, Santiago Muñoz, Guillermo Ramos, Antonio Orduña, Mar Siles-Lucas