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Table of Contents: June 2010

COVER

Lymphatic filariasis: A preventable disease.

Image Credit: GlaxoSmithKline
Issue Image

Lymphatic filariasis (LF) patients make shell decorations in a rehabilitation group in Tamil Nadu, India. Since 2000, global efforts have been underway to eliminate the spread of LF, a parasitic infection that is a leading cause of permanent and long-term disability worldwide. As a result of these global efforts, an estimated US$21.8 billion will be gained among individuals benefiting from the first eight years of the Global Programme to Eliminate Lymphatic Filariasis (GPELF), and an additional US$2.2 billion will be saved by the health systems of endemic countries (see Chu et al., 10.1371/journal.pntd.0000708).

Editorial

Viewpoints

Clinical Research in Resource-Limited Settings: Enhancing Research Capacity and Working Together to Make Trials Less Complicated

Trudie A. Lang, Nicholas J. White, Tran Tinh Hien, Jeremy J. Farrar, Nicholas P. J. Day, Raymond Fitzpatrick, Brian J. Angus, Emmanuelle Denis, Laura Merson, Phaik Yeong Cheah, Roma Chilengi, Robert Kimutai, Kevin Marsh

Expert Commentary

Policy Platform

The Centennial of the Discovery of Chagas Disease: Facing the Current Challenges

Joseli Lannes-Vieira, Tania C. de Araújo-Jorge, Maria de Nazaré Correia Soeiro, Paulo Gadelha, Rodrigo Corrêa-Oliveira

Symposium

How to (or Not to) Integrate Vertical Programmes for the Control of Major Neglected Tropical Diseases in Sub-Saharan Africa

Narcis B. Kabatereine, Mwele Malecela, Mounir Lado, Sam Zaramba, Olga Amiel, Jan H. Kolaczinski

Research Articles

Pulmonary Abnormalities in Mice with Paracoccidioidomycosis: A Sequential Study Comparing High Resolution Computed Tomography and Pathologic Findings

Damaris Lopera, Tonny Naranjo, José Miguel Hidalgo, Bernardo Miguel de Oliveira Pascarelli, Jairo Hernando Patiño, Henrique Leonel Lenzi, Angela Restrepo, Luz Elena Cano

Mechanisms of Vascular Damage by Hemorrhagic Snake Venom Metalloproteinases: Tissue Distribution and In Situ Hydrolysis

Cristiani Baldo, Colin Jamora, Norma Yamanouye, Telma M. Zorn, Ana M. Moura-da-Silva

Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

Wai-Lok Yau, Thierry Blisnick, Jean-François Taly, Manuela Helmer-Citterich, Cordelia Schiene-Fischer, Olivier Leclercq, Jing Li, Dirk Schmidt-Arras, Miguel A. Morales, Cedric Notredame, Daniel Romo, Philippe Bastin, Gerald F. Späth

Alcoholism and Strongyloides stercoralis: Daily Ethanol Ingestion Has a Positive Correlation with the Frequency of Strongyloides Larvae in the Stools

Carla Couzi Marques, Maria da Penha Zago-Gomes, Carlos Sandoval Gonçalves, Fausto Edmundo Lima Pereira

Unlocking the Transcriptomes of Two Carcinogenic Parasites, Clonorchis sinensis and Opisthorchis viverrini

Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Aaron R. Jex, Cinzia Cantacessi, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser

Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

Joshua M. Costin, Ekachai Jenwitheesuk, Shee-Mei Lok, Elizabeth Hunsperger, Kelly A. Conrads, Krystal A. Fontaine, Craig R. Rees, Michael G. Rossmann, Sharon Isern, Ram Samudrala, Scott F. Michael

The Global Burden of Alveolar Echinococcosis

Paul R. Torgerson, Krista Keller, Mellissa Magnotta, Natalie Ragland

Imported Episodic Rabies Increases Patient Demand for and Physician Delivery of Antirabies Prophylaxis

Zélie Lardon, Laurence Watier, Audrey Brunet, Claire Bernède, Maryvonne Goudal, Laurent Dacheux, Yolande Rotivel, Didier Guillemot, Hervé Bourhy

Isolation and Characterization of New Leptospira Genotypes from Patients in Mayotte (Indian Ocean)

Pascale Bourhy, Louis Collet, Sabine Clément, Michel Huerre, Patrick Ave, Claude Giry, François Pettinelli, Mathieu Picardeau

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

Vivekanandhan Aravindhan, Viswanathan Mohan, Jayagopi Surendar, Maradana Muralidhara Rao, Nathella Pavankumar, Mohan Deepa, Ramanujam Rajagopalan, Vasanthapuram Kumaraswami, Thomas B. Nutman, Subash Babu

Gene Expression Patterns of Dengue Virus-Infected Children from Nicaragua Reveal a Distinct Signature of Increased Metabolism

P'ng Loke, Samantha N. Hammond, Jacqueline M. Leung, Charles C. Kim, Sajeev Batra, Crisanta Rocha, Angel Balmaseda, Eva Harris

Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil

Claudilson J. C. Bastos, Roque Aras, Gildo Mota, Francisco Reis, Juarez Pereira Dias, Robson Silva de Jesus, Miralba Silva Freire, Eline G. de Araújo, Juliana Prazeres, Maria Fernanda Rios Grassi

Immunity to Lutzomyia intermedia Saliva Modulates the Inflammatory Environment Induced by Leishmania braziliensis

Tatiana R. de Moura, Fabiano Oliveira, Gabriele C. Rodrigues, Marcia W. Carneiro, Kiyoshi F. Fukutani, Fernanda O. Novais, José Carlos Miranda, Manoel Barral-Netto, Claudia Brodskyn, Aldina Barral, Camila I. de Oliveira

Spatial and Genetic Epidemiology of Hookworm in a Rural Community in Uganda

Rachel L. Pullan, Narcis B. Kabatereine, Rupert J. Quinnell, Simon Brooker

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

Tony Taldone, Victoria Gillan, Weilin Sun, Anna Rodina, Pallav Patel, Kirsty Maitland, Kerry O'Neill, Gabriela Chiosis, Eileen Devaney

New Assembly, Reannotation and Analysis of the Entamoeba histolytica Genome Reveal New Genomic Features and Protein Content Information

Hernan A. Lorenzi, Daniela Puiu, Jason R. Miller, Lauren M. Brinkac, Paolo Amedeo, Neil Hall, Elisabet V. Caler

Helminth Coinfection Does Not Affect Therapeutic Effect of a DNA Vaccine in Mice Harboring Tuberculosis

Fabiani G. Frantz, Rogério S. Rosada, Camila Peres-Buzalaf, Franciele R. T. Perusso, Vanderlei Rodrigues, Simone G. Ramos, Steven L. Kunkel, Célio L. Silva, Lúcia H. Faccioli

The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam

Nguyen Thi Khanh Nhu, Ha Vinh, Tran Vu Thieu Nga, Richard Stabler, Pham Thanh Duy, Le Thi Minh Vien, H. Rogier van Doorn, Ana Cerdeño-Tárraga, Nicholas Thomson, James Campbell, Nguyen Van Minh Hoang, Tran Thi Thu Nga, Pham Van Minh, Cao Thu Thuy, Brendan Wren, Jeremy Farrar, Stephen Baker

Immunostimulatory Properties of Dendritic Cells after Leishmania donovani Infection Using an In Vitro Model of Liver Microenvironment

Ludovic Donaghy, Florian Cabillic, Anne Corlu, Octavie Rostan, Olivier Toutirais, Christiane Guguen-Guillouzo, Claude Guiguen, Jean-Pierre Gangneux

Screening of Trypanosoma brucei gambiense in Domestic Livestock and Tsetse Flies from an Insular Endemic Focus (Luba, Equatorial Guinea)

Carlos Cordon-Obras, Carmen García-Estébanez, Nicolás Ndong-Mabale, Simón Abaga, Pedro Ndongo-Asumu, Agustín Benito, Jorge Cano

Visceral Leishmaniasis Relapse in Southern Sudan (1999–2007): A Retrospective Study of Risk Factors and Trends

Stanislaw Gorski, Simon M. Collin, Koert Ritmeijer, Kees Keus, Francis Gatluak, Marius Mueller, Robert N. Davidson

Burkholderia pseudomallei Is Spatially Distributed in Soil in Northeast Thailand

Direk Limmathurotsakul, Vanaporn Wuthiekanun, Narisara Chantratita, Gumphol Wongsuvan, Premjit Amornchai, Nicholas P. J. Day, Sharon J. Peacock

Lymphatic Filariasis Control in Tanzania: Effect of Repeated Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission

Paul E. Simonsen, Erling M. Pedersen, Rwehumbiza T. Rwegoshora, Mwelecele N. Malecela, Yahya A. Derua, Stephen M. Magesa

Rab11 and Actin Cytoskeleton Participate in Giardia lamblia Encystation, Guiding the Specific Vesicles to the Cyst Wall

Araceli Castillo-Romero, Gloria Leon-Avila, Ching C. Wang, Armando Perez Rangel, Minerva Camacho Nuez, Carlos Garcia Tovar, Jorge Tonatiuh Ayala-Sumuano, Juan Pedro Luna-Arias, Jose Manuel Hernandez

Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis

Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Markus M. Simon, Reinhard Wallich

Allergies and Diabetes as Risk Factors for Dengue Hemorrhagic Fever: Results of a Case Control Study

Maria Aparecida A. Figueiredo, Laura C. Rodrigues, Maurício L. Barreto, José Wellington O. Lima, Maria C. N. Costa, Vanessa Morato, Ronald Blanton, Pedro F. C. Vasconcelos, Márcio R. T. Nunes, Maria Glória Teixeira

The Economic Benefits Resulting from the First 8 Years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007)

Brian K. Chu, Pamela J. Hooper, Mark H. Bradley, Deborah A. McFarland, Eric A. Ottesen