Table of Contents: October 2011


Reconstruction of Inca granary (qollqa) at Cotapachi, Bolivia.

Image Credit: Michael Lewis (London School of Hygiene and Tropical Medicine)
Issue Image

Triatomine bugs are the vectors of Trypanosoma cruzi, the cause of Chagas disease. Most triatomines live in the wild, but some epidemiologically important species have adapted to living in and around human habitations. Human activities, such as stockpiling of grain, are thought to have encouraged vector domiciliation. The image is from a site near Cochabamba, which was a large Inca agricultural center and is still a focus of T. cruzi transmission by Triatoma infestans. The study used phylogenetic analysis of T. cruzi to show that human activities probably also promoted the evolution of hybrid lineages of the parasite (see Lewis et al., doi:10.1371/journal.pntd.0001363).


The Neglected Tropical Diseases of India and South Asia: Review of Their Prevalence, Distribution, and Control or Elimination

Derek A. Lobo, Raman Velayudhan, Priya Chatterjee, Harajeshwar Kohli, Peter J. Hotez


Toward Sustainable and Comprehensive Control of Schistosomiasis in China: Lessons from Sichuan

Edmund Y. W. Seto, Justin V. Remais, Elizabeth J. Carlton, Shuo Wang, Song Liang, Paul J. Brindley, Dongchuan Qiu, Robert C. Spear, Long-De Wang, Tian-Ping Wang, Hong-Gen Chen, Xing-Qi Dong, Li-Ying Wang, Yang Hao, Robert Bergquist, Xiao-Nong Zhou


Congenital Chagas Disease: Recommendations for Diagnosis, Treatment and Control of Newborns, Siblings and Pregnant Women

Yves Carlier, Faustino Torrico, Sergio Sosa-Estani, Graciela Russomando, Alejandro Luquetti, Hector Freilij, Pedro Albajar Vinas


Spontaneous Clearance of Mycobacterium ulcerans in a Case of Buruli Ulcer

Claire L. Gordon, John A. Buntine, John A. Hayman, Caroline J. Lavender, Janet A. Fyfe, Patrick Hosking, Paul D. R. Johnson

Research Articles

Alternative Oxidase Mediates Pathogen Resistance in Paracoccidioides brasiliensis Infection

Orville Hernández Ruiz, Angel Gonzalez, Agostinho J. Almeida, Diana Tamayo, Ana Maria Garcia, Angela Restrepo, Juan G. McEwen

Rodent Abundance Dynamics and Leptospirosis Carriage in an Area of Hyper-Endemicity in New Caledonia

Julie Perez, Fabrice Brescia, Jérôme Becam, Carine Mauron, Cyrille Goarant

Post-Treatment Follow-Up Study of Abdominal Cystic Echinococcosis in Tibetan Communities of Northwest Sichuan Province, China

Tiaoying Li, Akira Ito, Renqing Pengcuo, Yasuhito Sako, Xingwang Chen, Dongchuan Qiu, Ning Xiao, Philip S. Craig

Hidden Sylvatic Foci of the Main Vector of Chagas Disease Triatoma infestans: Threats to the Vector Elimination Campaign?

Leonardo A. Ceballos, Romina V. Piccinali, Paula L. Marcet, Gonzalo M. Vazquez-Prokopec, M. Victoria Cardinal, Judith Schachter-Broide, Jean-Pierre Dujardin, Ellen M. Dotson, Uriel Kitron, Ricardo E. Gürtler

Proteomic Identification of IPSE/alpha-1 as a Major Hepatotoxin Secreted by Schistosoma mansoni Eggs

Maha-Hamadien Abdulla, Kee-Chong Lim, James H. McKerrow, Conor R. Caffrey

Proteomic Analysis of Excretory-Secretory Products of Heligmosomoides polygyrus Assessed with Next-Generation Sequencing Transcriptomic Information

Yovany Moreno, Pierre-Paul Gros, Mifong Tam, Mariela Segura, Rajesh Valanparambil, Timothy G. Geary, Mary M. Stevenson

Efficacy of a Low-Cost, Inactivated Whole-Cell Oral Cholera Vaccine: Results from 3 Years of Follow-Up of a Randomized, Controlled Trial

Dipika Sur, Suman Kanungo, Binod Sah, Byomkesh Manna, Mohammad Ali, Allison M. Paisley, Swapan K. Niyogi, Jin Kyung Park, Banawarilal Sarkar, Mahesh K. Puri, Deok Ryun Kim, Jacqueline L. Deen, Jan Holmgren, Rodney Carbis, Raman Rao, Nguyen Thu Van, Seung Hyun Han, Stephen Attridge, Allan Donner, Nirmal K. Ganguly, Sujit K. Bhattacharya, G. Balakrish Nair, John D. Clemens, Anna Lena Lopez

Molecular Investigations of a Locally Acquired Case of Melioidosis in Southern AZ, USA

David M. Engelthaler, Jolene Bowers, James A. Schupp, Talima Pearson, Jennifer Ginther, Heidie M. Hornstra, Julia Dale, Tasha Stewart, Rebecca Sunenshine, Victor Waddell, Craig Levy, John Gillece, Lance B. Price, Tania Contente, Stephen M. Beckstrom-Sternberg, David D. Blaney, David M. Wagner, Mark Mayo, Bart J. Currie, Paul Keim, Apichai Tuanyok

Factors Affecting Infestation by Triatoma infestans in a Rural Area of the Humid Chaco in Argentina: A Multi-Model Inference Approach

Juan M. Gurevitz, Leonardo A. Ceballos, María Sol Gaspe, Julián A. Alvarado-Otegui, Gustavo F. Enríquez, Uriel Kitron, Ricardo E. Gürtler

Assessing the Effectiveness of a Community Intervention for Monkeypox Prevention in the Congo Basin

Amira A. Roess, Benjamin P. Monroe, Eric A. Kinzoni, Seamus Gallagher, Saturnin R. Ibata, Nkenda Badinga, Trolienne M. Molouania, Fredy S. Mabola, Jean V. Mombouli, Darin S. Carroll, Adam MacNeil, Noelle A. Benzekri, Cynthia Moses, Inger K. Damon, Mary G. Reynolds

Ebola Virion Attachment and Entry into Human Macrophages Profoundly Effects Early Cellular Gene Expression

Victoria Wahl-Jensen, Sabine Kurz, Friedericke Feldmann, Lukas K. Buehler, Jason Kindrachuk, Victor DeFilippis, Jean da Silva Correia, Klaus Früh, Jens H. Kuhn, Dennis R. Burton, Heinz Feldmann

Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon

Jean Paul Akue, Dieudonné Nkoghe, Cindy Padilla, Ghislain Moussavou, Hubert Moukana, Roger Antoine Mbou, Benjamin Ollomo, Eric Maurice Leroy

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical Disease in a Model of Arenavirus Hemorrhagic Fever

Michelle Mendenhall, Andrew Russell, Donald F. Smee, Jeffery O. Hall, Ramona Skirpstunas, Yousuke Furuta, Brian B. Gowen

Managing Tsetse Transmitted Trypanosomosis by Insecticide Treated Nets - an Affordable and Sustainable Method for Resource Poor Pig Farmers in Ghana

Burkhard Bauer, Bettina Holzgrefe, Charles Ibrahim Mahama, Maximilian P. O. Baumann, Dieter Mehlitz, Peter-Henning Clausen

Canine Antibody Response to Phlebotomus perniciosus Bites Negatively Correlates with the Risk of Leishmania infantum Transmission

Michaela Vlkova, Iva Rohousova, Jan Drahota, Dorothee Stanneck, Eva Maria Kruedewagen, Norbert Mencke, Domenico Otranto, Petr Volf

Epidemiological and Entomological Evaluations after Six Years or More of Mass Drug Administration for Lymphatic Filariasis Elimination in Nigeria

Frank O. Richards, Abel Eigege, Emmanuel S. Miri, Alphonsus Kal, John Umaru, Davou Pam, Lindsay J. Rakers, Yohanna Sambo, Jacob Danboyi, Bako Ibrahim, Solomon E. Adelamo, Gladys Ogah, Danjuma Goshit, O. Kehinde Oyenekan, Els Mathieu, P. Craig Withers, Yisa A. Saka, Jonathan Jiya, Donald R. Hopkins

Genetic Manipulation of Schistosoma haematobium, the Neglected Schistosome

Gabriel Rinaldi, Tunika I. Okatcha, Anastas Popratiloff, Mary A. Ayuk, Sutas Suttiprapa, Victoria H. Mann, Yung-san Liang, Fred A. Lewis, Alex Loukas, Paul J. Brindley

Re-Emergence of Crimean-Congo Hemorrhagic Fever Virus in Central Africa

Gilda Grard, Jan Felix Drexler, Joseph Fair, Jean-Jacques Muyembe, Nathan D. Wolfe, Christian Drosten, Eric M. Leroy

Impact of Health Research Capacity Strengthening in Low- and Middle-Income Countries: The Case of WHO/TDR Programmes

Happiness Minja, Christian Nsanzabana, Christine Maure, Axel Hoffmann, Susan Rumisha, Olumide Ogundahunsi, Fabio Zicker, Marcel Tanner, Pascal Launois

Evaluation of qPCR-Based Assays for Leprosy Diagnosis Directly in Clinical Specimens

Alejandra Nóbrega Martinez, Marcelo Ribeiro-Alves, Euzenir Nunes Sarno, Milton Ozório Moraes

Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids

Michael D. Lewis, Martin S. Llewellyn, Matthew Yeo, Nidia Acosta, Michael W. Gaunt, Michael A. Miles

Incidence of Symptomatic and Asymptomatic Leishmania donovani Infections in High-Endemic Foci in India and Nepal: A Prospective Study

Bart Ostyn, Kamlesh Gidwani, Basudha Khanal, Albert Picado, François Chappuis, Shri Prakash Singh, Suman Rijal, Shyam Sundar, Marleen Boelaert

Preexisting Japanese Encephalitis Virus Neutralizing Antibodies and Increased Symptomatic Dengue Illness in a School-Based Cohort in Thailand

Kathryn B. Anderson, Robert V. Gibbons, Stephen J. Thomas, Alan L. Rothman, Ananda Nisalak, Ruth L. Berkelman, Daniel H. Libraty, Timothy P. Endy

Functional Expression of Parasite Drug Targets and Their Human Orthologs in Yeast

Elizabeth Bilsland, Pınar Pir, Alex Gutteridge, Alexander Johns, Ross D. King, Stephen G. Oliver

Imaginal Discs – A New Source of Chromosomes for Genome Mapping of the Yellow Fever Mosquito Aedes aegypti

Maria V. Sharakhova, Vladimir A. Timoshevskiy, Fan Yang, Sergei Iu. Demin, David W. Severson, Igor V. Sharakhov

Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

Jae-Hwan Kim, Min-Ho Choi, Young Mee Bae, Jin-Kyoung Oh, Min Kyung Lim, Sung-Tae Hong

Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner

Rhiannon R. White, Sachiko Miyata, Eliseo Papa, Eric Spooner, Kleoniki Gounaris, Murray E. Selkirk, Katerina Artavanis-Tsakonas

Human Cellular Immune Response to the Saliva of Phlebotomus papatasi Is Mediated by IL-10-Producing CD8+ T Cells and Th1-Polarized CD4+ Lymphocytes

Maha Abdeladhim, Mélika Ben Ahmed, Soumaya Marzouki, Nadia Belhadj Hmida, Thouraya Boussoffara, Nabil Belhaj Hamida, Afif Ben Salah, Hechmi Louzir

Ancient Ancestry of KFDV and AHFV Revealed by Complete Genome Analyses of Viruses Isolated from Ticks and Mammalian Hosts

Kimberly A. Dodd, Brian H. Bird, Marina L. Khristova, César G. Albariño, Serena A. Carroll, James A. Comer, Bobbie R. Erickson, Pierre E. Rollin, Stuart T. Nichol