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Table of Contents: April 2012

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Ivermectin distribution under the Mectizan Donation Program has been undertaken annually in Ghana. Community ivermectin distributors are located in each endemic community. The number of Mectizan tablets (1–4) is determined by measuring the height of individuals as a surrogate for body weight on the basis of a dose rate of 150 µg/kg. CDTI was developed under the Onchocerciasis Control Programme for West Africa and has been used by the African Programme for Onchocerciasis Control. See Prichard et al.

Editorial

Reviews

A Research Agenda for Helminth Diseases of Humans: Basic Research and Enabling Technologies to Support Control and Elimination of Helminthiases

Sara Lustigman, Peter Geldhof, Warwick N. Grant, Mike Y. Osei-Atweneboana, Banchob Sripa, María-Gloria Basáñez

A Research Agenda for Helminth Diseases of Humans: Towards Control and Elimination

Boakye A. Boatin, María-Gloria Basáñez, Roger K. Prichard, Kwablah Awadzi, Rashida M. Barakat, Héctor H. García, Andrea Gazzinelli, Warwick N. Grant, James S. McCarthy, Eliézer K. N'Goran, Mike Y. Osei-Atweneboana, Banchob Sripa, Guo-Jing Yang, Sara Lustigman

A Research Agenda for Helminth Diseases of Humans: Modelling for Control and Elimination

María-Gloria Basáñez, James S. McCarthy, Michael D. French, Guo-Jing Yang, Martin Walker, Manoj Gambhir, Roger K. Prichard, Thomas S. Churcher

A Research Agenda for Helminth Diseases of Humans: Intervention for Control and Elimination

Roger K. Prichard, María-Gloria Basáñez, Boakye A. Boatin, James S. McCarthy, Héctor H. García, Guo-Jing Yang, Banchob Sripa, Sara Lustigman

A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases

Sara Lustigman, Roger K. Prichard, Andrea Gazzinelli, Warwick N. Grant, Boakye A. Boatin, James S. McCarthy, María-Gloria Basáñez

A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmes

James S. McCarthy, Sara Lustigman, Guo-Jing Yang, Rashida M. Barakat, Héctor H. García, Banchob Sripa, Arve Lee Willingham, Roger K. Prichard, María-Gloria Basáñez

A Research Agenda for Helminth Diseases of Humans: Health Research and Capacity Building in Disease-Endemic Countries for Helminthiases Control

Mike Y. Osei-Atweneboana, Sara Lustigman, Roger K. Prichard, Boakye A. Boatin, María-Gloria Basáñez

A Research Agenda for Helminth Diseases of Humans: Social Ecology, Environmental Determinants, and Health Systems

Andrea Gazzinelli, Rodrigo Correa-Oliveira, Guo-Jing Yang, Boakye A. Boatin, Helmut Kloos

Research Articles

Community Risk Factors for Ocular Chlamydia Infection in Niger: Pre-Treatment Results from a Cluster-Randomized Trachoma Trial

Abdou Amza, Boubacar Kadri, Baido Nassirou, Nicole E. Stoller, Sun N. Yu, Zhaoxia Zhou, Stephanie Chin, Sheila K. West, Robin L. Bailey, David C. W. Mabey, Jeremy D. Keenan, Travis C. Porco, Thomas M. Lietman, Bruce D. Gaynor , for the PRET Partnership

Pathogen-Specific Epitopes as Epidemiological Tools for Defining the Magnitude of Mycobacterium leprae Transmission in Areas Endemic for Leprosy

Marcia V. S. B. Martins, Marjorie M. da S. Guimarães, John S. Spencer, Mariana A. V. B. Hacker, Luciana S. Costa, Fernanda M. Carvalho, Annemieke Geluk, Jolien J. van der Ploeg-van Schip, Maria A. A. Pontes, Heitor S. Gonçalves, Janvier P. de Morais, Tereza J. P. G. Bandeira, Maria C. V. Pessolani, Patrick J. Brennan, Geraldo M. B. Pereira

Innate Immune Response to Rift Valley Fever Virus in Goats

Charles K. Nfon, Peter Marszal, Shunzhen Zhang, Hana M. Weingartl

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Andrew S. Bell, James E. Mills, Gareth P. Williams, James A. Brannigan, Anthony J. Wilkinson, Tanya Parkinson, Robin J. Leatherbarrow, Edward W. Tate, Anthony A. Holder, Deborah F. Smith

Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species

Daniel Rodriguez-Pinto, Adriana Navas, Víctor Manuel Blanco, Lady Ramírez, Daniel Garcerant, Adriana Cruz, Noah Craft, Nancy Gore Saravia

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez, Grace Kelly Silva, Renata Dellalibera-Joviliano, Gerson Jhonatan Rodrigues, Lusiane Maria Bendhack, Anis Rassi Jr, Anis Rassi, André Schmidt, Benedito Carlos Maciel, José Antonio Marin Neto, João Santana Silva

Dengue Deaths in Puerto Rico: Lessons Learned from the 2007 Epidemic

Kay M. Tomashek, Christopher J. Gregory, Aidsa Rivera Sánchez, Matthew A. Bartek, Enid J. Garcia Rivera, Elizabeth Hunsperger, Jorge L. Muñoz-Jordán, Wellington Sun

Long-Term Impact of the World Bank Loan Project for Schistosomiasis Control: A Comparison of the Spatial Distribution of Schistosomiasis Risk in China

Zhijie Zhang, Rong Zhu, Michael P. Ward, Wanghong Xu, Lijuan Zhang, Jiagang Guo, Fei Zhao, Qingwu Jiang

Synergistic Interactions between the NS3hel and E Proteins Contribute to the Virulence of Dengue Virus Type 1

Luana de Borba, Daisy M. Strottmann, Lucia de Noronha, Peter W. Mason, Claudia N. Duarte dos Santos

Higher Expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 Chemokines in the Skin Associated with Parasite Density in Canine Visceral Leishmaniasis

Daniel Menezes-Souza, Renata Guerra-Sá, Cláudia Martins Carneiro, Juliana Vitoriano-Souza, Rodolfo Cordeiro Giunchetti, Andréa Teixeira-Carvalho, Denise Silveira-Lemos, Guilherme Corrêa Oliveira, Rodrigo Corrêa-Oliveira, Alexandre Barbosa Reis

Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing

Louisa A. Messenger, Martin S. Llewellyn, Tapan Bhattacharyya, Oscar Franzén, Michael D. Lewis, Juan David Ramírez, Hernan J. Carrasco, Björn Andersson, Michael A. Miles

Prevalence of Trachoma in Unity State, South Sudan: Results from a Large-Scale Population-Based Survey and Potential Implications for Further Surveys

Tansy Edwards, Jennifer Smith, Hugh J. W. Sturrock, Lucia W. Kur, Anthony Sabasio, Timothy P. Finn, Mounir Lado, Danny Haddad, Jan H. Kolaczinski

Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam

Darren J. Gray, Aaron P. Thrift, Gail M. Williams, Feng Zheng, Yue-Sheng Li, Jiagang Guo, Honggen Chen, Tianping Wang, Xin Jiang Xu, Rong Zhu, Hongqing Zhu, Chun Li Cao, Dan Dan Lin, Zhen Yuan Zhao, Robert S. Li, George M. Davis, Donald P. McManus

Canine Skin and Conjunctival Swab Samples for the Detection and Quantification of Leishmania infantum DNA in an Endemic Urban Area in Brazil

Sidney de Almeida Ferreira, Rodrigo Souza Leite, Leonardo Trindade Ituassu, Gregório Guilherme Almeida, Daniel Menezes Souza, Ricardo Toshio Fujiwara, Antero Silva Ribeiro de Andrade, Maria Norma Melo

Epidemiology and Molecular Relationships of Cryptosporidium spp. in People, Primates, and Livestock from Western Uganda

Stephanie J. Salyer, Thomas R. Gillespie, Innocent B. Rwego, Colin A. Chapman, Tony L. Goldberg

In Vitro and In Vivo Efficacy of Ether Lipid Edelfosine against Leishmania spp. and SbV-Resistant Parasites

Rubén E. Varela-M, Janny A. Villa-Pulgarin, Edward Yepes, Ingrid Müller, Manuel Modolell, Diana L. Muñoz, Sara M. Robledo, Carlos E. Muskus, Julio López-Abán, Antonio Muro, Iván D. Vélez, Faustino Mollinedo

Prevalence, Features and Risk Factors for Malaria Co-Infections amongst Visceral Leishmaniasis Patients from Amudat Hospital, Uganda

Erika van den Bogaart, Marieke M. Z. Berkhout, Emily R. Adams, Pètra F. Mens, Elizabeth Sentongo, Dawson B. Mbulamberi, Masja Straetemans, Henk D. F. H. Schallig, Francois Chappuis

Human and Canine Echinococcosis Infection in Informal, Unlicensed Abattoirs in Lima, Peru

Maria M. Reyes, Claudia P. Taramona, Mardeli Saire-Mendoza, Cesar M. Gavidia, Eduardo Barron, Belgees Boufana, Philip S. Craig, Luis Tello, Hector H. Garcia, Saul J. Santivañez

Investigation of the Proteolytic Functions of an Expanded Cercarial Elastase Gene Family in Schistosoma mansoni

Jessica R. Ingram, Salma B. Rafi, A. Alegra Eroy-Reveles, Manisha Ray, Laura Lambeth, Ivy Hsieh, Debbie Ruelas, K. C. Lim, Judy Sakanari, Charles S. Craik, Matthew P. Jacobson, James H. McKerrow

Detection of Mycobacterium ulcerans by the Loop Mediated Isothermal Amplification Method

Anthony Ablordey, Diana Ackon Amissah, Isaac Frimpong Aboagye, Ben Hatano, Toshio Yamazaki, Tetsutaro Sata, Koichi Ishikawa, Harutaka Katano

Population Structure and Transmission Dynamics of Plasmodium vivax in the Republic of Korea Based on Microsatellite DNA Analysis

Moritoshi Iwagami, Megumi Fukumoto, Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho, Shigeyuki Kano

The Schistosoma mansoni Tegumental-Allergen-Like (TAL) Protein Family: Influence of Developmental Expression on Human IgE Responses

Colin M. Fitzsimmons, Frances M. Jones, Alex Stearn, Iain W. Chalmers, Karl F. Hoffmann, Jakub Wawrzyniak, Shona Wilson, Narcis B. Kabatereine, David W. Dunne

IFN-γ Plays a Unique Role in Protection against Low Virulent Trypanosoma cruzi Strain

Adele A. Rodrigues, Jasson S. S. Saosa, Grace K. da Silva, Flávia A. Martins, Aline A. da Silva, Cecílio P. da Silva Souza Neto, Catarina V. Horta, Dario S. Zamboni, João S. da Silva, Eloisa A. V. Ferro, Claudio V. da Silva

Second External Quality Assurance Study for the Serological Diagnosis of Hantaviruses in Europe

Camille Escadafal, Tatjana Avšič-Županc, Olli Vapalahti, Bo Niklasson, Anette Teichmann, Matthias Niedrig, Oliver Donoso-Mantke

Increased Birth Weight Associated with Regular Pre-Pregnancy Deworming and Weekly Iron-Folic Acid Supplementation for Vietnamese Women

Luca Passerini, Gerard J. Casey, Beverley A. Biggs, Dai T. Cong, Luong B. Phu, Tran Q. Phuc, Marco Carone, Antonio Montresor

Incrimination of Phlebotomus kandelakii and Phlebotomus balcanicus as Vectors of Leishmania infantum in Tbilisi, Georgia

Ekaterina Giorgobiani, Phillip G. Lawyer, Giorgi Babuadze, Nato Dolidze, Ryan C. Jochim, Lamzira Tskhvaradze, Konstantin Kikaleishvili, Shaden Kamhawi

KSAC, a Defined Leishmania Antigen, plus Adjuvant Protects against the Virulence of L. major Transmitted by Its Natural Vector Phlebotomus duboscqi

Regis Gomes, Clarissa Teixeira, Fabiano Oliveira, Phillip G. Lawyer, Dia-Eldin Elnaiem, Claudio Meneses, Yasuyuki Goto, Ajay Bhatia, Randall F. Howard, Steven G. Reed, Jesus G. Valenzuela, Shaden Kamhawi

Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti

Kathrin Arndts, Susanne Deininger, Sabine Specht, Ute Klarmann, Sabine Mand, Tomabu Adjobimey, Alexander Y. Debrah, Linda Batsa, Alexander Kwarteng, Christian Epp, Mark Taylor, Ohene Adjei, Laura E. Layland, Achim Hoerauf