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Research Article

Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

  • Elizabeth R. Sharlow,

    Affiliations: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • David Close,

    Affiliation: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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  • Tongying Shun,

    Affiliation: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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  • Stephanie Leimgruber,

    Affiliation: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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  • Robyn Reed,

    Affiliation: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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  • Gabriela Mustata,

    Affiliation: Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Peter Wipf,

    Affiliations: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Jacob Johnson,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Michael O'Neil,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Max Grögl,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Alan J. Magill,

    Affiliation: Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • John S. Lazo mail

    lazo@pitt.edu

    Affiliations: University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: November 03, 2009
  • DOI: 10.1371/journal.pntd.0000540

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