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Research Article

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

  • Gregory J. Crowther mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Dhanasekaran Shanmugam,

    Affiliation: Department of Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Santiago J. Carmona,

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Buenos Aires, Argentina

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  • Maria A. Doyle,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

    Current address: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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  • Christiane Hertz-Fowler,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    Current address: Centre for Genomic Research, School of Biological Science, University of Liverpool, Liverpool, United Kingdom

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  • Matthew Berriman,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Solomon Nwaka,

    Affiliation: Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Stuart A. Ralph mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

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  • David S. Roos mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Department of Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Wesley C. Van Voorhis mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Fernán Agüero mail

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Buenos Aires, Argentina

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  • Published: August 24, 2010
  • DOI: 10.1371/journal.pntd.0000804

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