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Research Article

Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

  • Gerritje J. W. van der Windt,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • W. Joost Wiersinga,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • Catharina W. Wieland,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • Ivo C. S. I. Tjia,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • Nicholas P. Day,

    Affiliations: Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom

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  • Sharon J. Peacock,

    Affiliations: Mahidol University, Bangkok, Thailand, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

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  • Sandrine Florquin,

    Affiliation: Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

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  • Tom van der Poll mail

    t.vanderpoll@amc.uva.nl

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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  • Published: August 31, 2010
  • DOI: 10.1371/journal.pntd.0000806

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