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Research Article

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation

  • Sabine Kuettel,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Jason Greenwald,

    Affiliation: Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland

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  • Dirk Kostrewa,

    Affiliation: Gene Center Munich, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Shaheen Ahmed,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Leonardo Scapozza mail,

    leonardo.scapozza@unige.ch (LS); remo.perozzo@unige.ch (RP)

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Remo Perozzo mail

    leonardo.scapozza@unige.ch (LS); remo.perozzo@unige.ch (RP)

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Published: May 24, 2011
  • DOI: 10.1371/journal.pntd.0001164

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