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Research Article

Knockout of the dhfr-ts Gene in Trypanosoma cruzi Generates Attenuated Parasites Able to Confer Protection against a Virulent Challenge

  • Cecilia Perez Brandan mail,

    cecilia.perezbrandan@conicet.gov.ar

    Affiliation: Instituto de Patologia Experimental - CONICET, Universidad Nacional de Salta, Salta, Argentina

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  • Angel M. Padilla,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

    X
  • Dan Xu,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

    X
  • Rick L. Tarleton,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Miguel A. Basombrio

    Affiliation: Instituto de Patologia Experimental - CONICET, Universidad Nacional de Salta, Salta, Argentina

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  • Published: December 13, 2011
  • DOI: 10.1371/journal.pntd.0001418

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