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Research Article

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

  • John K. Thuita mail,

    thuitajk@yahoo.com (JKT); Reto.brun@unibas.ch (RB)

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Michael Z. Wang,

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • John M. Kagira,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Cathrine L. Denton,

    Affiliation: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Mary F. Paine,

    Affiliation: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Raymond E. Mdachi,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Grace A. Murilla,

    Affiliation: Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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  • Shelley Ching,

    Affiliation: SVC Associates, Inc., Apex, North Carolina, United States of America

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  • David W. Boykin,

    Affiliation: Chemistry Department, Georgia State University, Atlanta, Georgia, United States of America

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  • Richard R. Tidwell,

    Affiliation: Pathology Department, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America

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  • James E. Hall,

    Affiliation: Pathology Department, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America

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  • Reto Brun mail

    thuitajk@yahoo.com (JKT); Reto.brun@unibas.ch (RB)

    Affiliation: Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pntd.0001734

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