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Research Article

Lipidated Dengue-2 Envelope Protein Domain III Independently Stimulates Long-Lasting Neutralizing Antibodies and Reduces the Risk of Antibody-Dependent Enhancement

  • Chen-Yi Chiang equal contributor,

    equal contributor Contributed equally to this work with: Chen-Yi Chiang, Chien-Hsiung Pan

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Chien-Hsiung Pan equal contributor,

    equal contributor Contributed equally to this work with: Chen-Yi Chiang, Chien-Hsiung Pan

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Chun-Hsiang Hsieh,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Jy-Ping Tsai,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Mei-Yu Chen,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Hsueh-Hung Liu,

    Affiliation: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

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  • Shih-Jen Liu,

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Pele Chong,

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

    X
  • Chih-Hsiang Leng mail,

    leoleng@nhri.org.tw (CHL); chenhw@nhri.org.tw (HWC)

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Hsin-Wei Chen mail

    leoleng@nhri.org.tw (CHL); chenhw@nhri.org.tw (HWC)

    Affiliations: National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China

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  • Published: September 19, 2013
  • DOI: 10.1371/journal.pntd.0002432

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