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Research Article

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

  • Juan Carlos Pizarro mail,

    juan.pizarro@utoronto.ca

    Affiliations: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America

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  • Tanya Hills,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Guillermo Senisterra,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Amy K. Wernimont,

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Claire Mackenzie,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Neil R. Norcross,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Michael A. J. Ferguson,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Paul G. Wyatt,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Ian H. Gilbert,

    Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Raymond Hui

    Affiliation: The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada

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  • Published: October 17, 2013
  • DOI: 10.1371/journal.pntd.0002492

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