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Research Article

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

  • Juan P. Rigalli,

    Affiliations: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina, Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Virginia G. Perdomo,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Marcelo G. Luquita,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Silvina S. M. Villanueva,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Agostina Arias,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Dirk Theile,

    Affiliation: Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Johanna Weiss,

    Affiliation: Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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  • Aldo D. Mottino,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • María L. Ruiz,

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Viviana A. Catania mail

    vcatania@fbioyf.unr.edu.ar

    Affiliation: Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.pntd.0001951

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