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Research Article

Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

  • Simone Pieretti equal contributor,

    equal contributor Contributed equally to this work with: Simone Pieretti, Jurgen R. Haanstra

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland, Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Jurgen R. Haanstra equal contributor,

    equal contributor Contributed equally to this work with: Simone Pieretti, Jurgen R. Haanstra

    Affiliations: Department of Pediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Muriel Mazet,

    Affiliation: Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium

    Current address: Centre de Résonance Magnétique des Systèmes Biologiques (RMSB), UMR 5536 CNRS, Université Victor Segalen Bordeaux 2, Bordeaux, France

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  • Remo Perozzo,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

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  • Christian Bergamini,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Federica Prati,

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy

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  • Romana Fato,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Giorgio Lenaz,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Giovanni Capranico,

    Affiliation: Department of Biochemistry, University of Bologna, Bologna, Italy

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  • Reto Brun,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Barbara M. Bakker,

    Affiliations: Department of Pediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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  • Paul A. M. Michels,

    Affiliation: Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université Catholique de Louvain, Brussels, Belgium

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  • Leonardo Scapozza,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

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  • Maria Laura Bolognesi mail,

    marialaura.bolognesi@unibo.it (MLB); andrea.cavalli@unibo.it (AC)

    Affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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  • Andrea Cavalli mail

    marialaura.bolognesi@unibo.it (MLB); andrea.cavalli@unibo.it (AC)

    Affiliations: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy, Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pntd.0002012

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