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Research Article

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

  • Chiung-Kuang Chen,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Siegfried S. F. Leung,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Christophe Guilbert,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Matthew P. Jacobson,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • Larissa M. Podust mail

    larissa.podust@ucsf.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Published: April 06, 2010
  • DOI: 10.1371/journal.pntd.0000651

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