Advertisement
Research Article

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

  • Elizabeth R. Sharlow,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Todd A. Lyda,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

    X
  • Heidi C. Dodson,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

    X
  • Gabriela Mustata,

    Affiliation: Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Meredith T. Morris,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

    X
  • Stephanie S. Leimgruber,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Kuo-Hsiung Lee,

    Affiliation: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Yoshiki Kashiwada,

    Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan

    X
  • David Close,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • John S. Lazo,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • James C. Morris mail

    jmorri2@clemson

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

    X
  • Published: April 13, 2010
  • DOI: 10.1371/journal.pntd.0000659

Viewed info

Cited info

Saved info

Discussed info

Questions or concerns about usage data? Please let us know.