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Research Article

Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

  • Wai-Lok Yau,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Thierry Blisnick,

    Affiliation: Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Jean-François Taly,

    Affiliation: Centre de Regulacio Genomica (CRG), Universitat Pompeus Fabre, Barcelona, Spain

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  • Manuela Helmer-Citterich,

    Affiliation: Centre for Molecular Bioinformatics, Department of Biology, University of Rome Tor Vergata, Rome, Italy

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  • Cordelia Schiene-Fischer,

    Affiliation: Max-Planck Research Unit for Enzymology of Protein Folding, Halle/Saale, Germany

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  • Olivier Leclercq,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Jing Li,

    Affiliation: Texas A&M Natural Products LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America

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  • Dirk Schmidt-Arras,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Miguel A. Morales,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Cedric Notredame,

    Affiliation: Centre de Regulacio Genomica (CRG), Universitat Pompeus Fabre, Barcelona, Spain

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  • Daniel Romo,

    Affiliations: Texas A&M Natural Products LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America

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  • Philippe Bastin,

    Affiliation: Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Gerald F. Späth mail

    gerald.spaeth@pasteur.fr

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Published: June 29, 2010
  • DOI: 10.1371/journal.pntd.0000729

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