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Research Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

  • Kenny K. H. Ang,

    Affiliation: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Joseline Ratnam,

    Affiliation: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Jiri Gut,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Jennifer Legac,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Elizabeth Hansell,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Zachary B. Mackey,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Katarzyna M. Skrzypczynska,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Anjan Debnath,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Juan C. Engel,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Philip J. Rosenthal,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliations: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Michelle R. Arkin mail,

    michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

    Affiliations: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Adam R. Renslo mail

    michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

    Affiliations: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Published: May 03, 2011
  • DOI: 10.1371/journal.pntd.0001023

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