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Research Article

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

  • Roderick G. Walker,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Graeme Thomson,

    Affiliation: Cyclacel Ltd., Dundee, Dundee, United Kingdom

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  • Kirk Malone,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom

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  • Matthew W. Nowicki,

    Affiliation: Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom

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  • Elaine Brown,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • David G. Blake,

    Affiliation: Cyclacel Ltd., Dundee, Dundee, United Kingdom

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  • Nicholas J. Turner,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom

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  • Malcolm D. Walkinshaw,

    Affiliation: Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom

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  • Karen M. Grant,

    Affiliation: School of Health & Medicine, Division of Medicine, Lancaster University, Lancaster, United Kingdom

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  • Jeremy C. Mottram mail

    j.mottram@udcf.gla.ac.uk

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Published: April 05, 2011
  • DOI: 10.1371/journal.pntd.0001033

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