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Research Article

A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg/kg vs. 60 mg/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil

  • Piero L. Olliaro,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

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  • Michel T. Vaillant mail,

    michel.vaillant@crp-sante.lu

    Affiliation: Methodology and Statistical Unit, Center for Health Studies, Centre de Recherche – Santé, Strassen, Luxembourg

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  • Vincente J. Belizario,

    Affiliation: National Institutes of Health, University of the Philippines Manila, Manila, Philippines

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  • Nicholas J. S. Lwambo †,

    † Deceased.

    Affiliation: National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

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  • Mohamed Ouldabdallahi,

    Affiliation: Nutrition et Actes Médicaux, Institut National de Recherches en Santé Publique (INRSP), Nouakchott, Mauritania

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  • Otavio S. Pieri,

    Affiliation: Laboratorio de Eco-Epidemiologia e Controle da Esquistossomose e Geohelmintoses, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil

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  • Maria L. Amarillo,

    Affiliation: Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines

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  • Godfrey M. Kaatano,

    Affiliation: National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

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  • Mamadou Diaw,

    Affiliation: Ministère de la Santé/P.E.V., Nouakchott, Mauritania

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  • AnaLucia C. Domingues,

    Affiliation: Departamento de Medicina Clinica, Centro de Ciencias da Saude, UFPE, Hospital das Clinicas, Recife, Brazil

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  • Tereza C. Favre,

    Affiliation: Laboratorio de Eco-Epidemiologia e Controle da Esquistossomose e Geohelmintoses, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil

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  • Olivier Lapujade,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

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  • Fabiana Alves,

    Affiliation: Latin America Regional Office, Drugs for Neglected Diseases Initiative, Rio de Janeiro, Brazil

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  • Lester Chitsulo

    Affiliation: Preventive Chemotherapy and Transmission Control Unit, Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Published: June 14, 2011
  • DOI: 10.1371/journal.pntd.0001165

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