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Research Article

Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease

  • Paulo Marcos Matta Guedes equal contributor,

    equal contributor Contributed equally to this work with: Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez

    Affiliations: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil, Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Fredy Roberto Salazar Gutierrez equal contributor,

    equal contributor Contributed equally to this work with: Paulo Marcos Matta Guedes, Fredy Roberto Salazar Gutierrez

    Affiliations: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil, School of Medicine, University Antonio Narino, Bogota, Colombia

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  • Grace Kelly Silva,

    Affiliation: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Renata Dellalibera-Joviliano,

    Affiliation: Integrated Faculty Fafibe and Department of Surgery and Anatomy, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Gerson Jhonatan Rodrigues,

    Affiliation: Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Lusiane Maria Bendhack,

    Affiliation: Department of Physical and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Anis Rassi Jr,

    Affiliation: Division of Cardiology, Anis Rassi Hospital, Goiânia, Brazil

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  • Anis Rassi,

    Affiliation: Division of Cardiology, Anis Rassi Hospital, Goiânia, Brazil

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  • André Schmidt,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Benedito Carlos Maciel,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • José Antonio Marin Neto,

    Affiliation: Division of Cardiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • João Santana Silva mail

    jsdsilva@fmrp.usp.br

    Affiliation: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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  • Published: April 24, 2012
  • DOI: 10.1371/journal.pntd.0001630

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