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Research Article

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica

  • Ileana Corvo,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Anthony J. O'Donoghue,

    Affiliation: Department of Pharmaceutical Chemistry, Pharmacology, and Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

    X
  • Lucía Pastro,

    Affiliations: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay, Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Natalia Pi-Denis,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Alegra Eroy-Reveles,

    Affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California, United States of America

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  • Leda Roche,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • James H. McKerrow,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California, San Francisco, California, United States of America

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  • John P. Dalton,

    Affiliation: Institute of Parasitology, McGill University, Quebec, Canada

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  • Charles S. Craik,

    Affiliation: Department of Pharmaceutical Chemistry, Pharmacology, and Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

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  • Conor R. Caffrey,

    Affiliation: Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California, San Francisco, California, United States of America

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  • José F. Tort mail

    jtort@fmed.edu.uy

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, UDELAR, Montevideo, Uruguay

    X
  • Published: July 11, 2013
  • DOI: 10.1371/journal.pntd.0002269

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